Navigation Links
World-first swine-flu vaccine trial reveals one dose provides 'strong immune response'

Results from the first swine-flu vaccine trials taking place in Leicester reveal a strong immune response after just one dose.

The pilot study, run by the University of Leicester and Leicester Hospitals, was trialled with 100 healthy volunteers, aged between 18 and 50.

Dr Iain Stephenson, who led the trial at the Leicester Royal Infirmary, said: "The clinical trial of Novartis MF59-adjuvanted cell-based A (H1N1) vaccine indicates that the "swine flu" vaccine elicits a strong immune response and is well-tolerated.

"Results showed that the serum antibody responses were highest among subjects who received two doses of vaccine, however a single vaccine dose also induced responses associated with protection against influenza.

"The findings showed that it is possible to induce protective antibody against A(H1N1) infection within two weeks of administration of a single low-dose adjuvanted vaccine."

Non-adjuvanted formulations were not evaluated in this part of the study and will be evaluated shortly

The trial evaluated the tolerability and immunogenicity of the vaccine, and tested different schedules of vaccination, in terms of time between vaccinations. The vaccine schedule was one or two doses of 7.5μg MF-59 adjuvanted surface-antigen A/California/2009 vaccine derived from cell-culture.

Dr. Stephenson, of the Department of Infection, Immunity and Inflammation at the University of Leicester is a clinical senior lecturer at the University, and a consultant in infectious diseases at the University Hospitals of Leicester NHS Trust. He said: "The aim of the trial was to find out how many doses and what type of vaccine is needed to give protection. These initial results should help to plan vaccination campaigns in the autumn, including doses and timings. We concluded that the MF59-adjuvanted A(H1N1) vaccine of low antigen content was well tolerated and generated antibody responses associated with protection against influenza, even after a single dose."

"The results suggest that one vaccine dose may be sufficient to protect against the A(H1N1) swine flu, rather than two. Larger trials are already underway around the world. Timings on when the vaccine will be available to governments will depend on the results of these clinical trials, and approvals by regulatory authorities''

The research found the vaccine is well tolerated with pain at the injection site the most frequent adverse event.

Additional pivotal trials with both cell culture and traditional egg based vaccines under way around the world that will include more than 6000 adults and children.

Previous research had indicated that two doses of the vaccine would be needed against swine flu. You can access earlier stories here:


Contact: Ather Mirza
University of Leicester

Related biology news :

1. Study of African traditional medicine will begin world-first clinical trial
2. World-first to predict premature births
3. A world-first in solar technology unveiled at Concordia University
4. Britains first swine-flu trials under way
5. Possible hepatitis C vaccine
6. Study by Pittsburgh researchers identifies possible vaccine target for chlamydia
7. New nanoparticle vaccine is more effective but less expensive
8. Flu vaccine in painless skin patches under development at Emory, Georgia Tech with NIH grants
9. Influenza vaccine causes weaker immune response for children of rural Gabon than in semi-urban areas
10. An Alzheimers vaccine?
11. Penn researchers find monkeys able to fend off AIDS-like symptoms with enhanced HIV vaccine
Post Your Comments:
(Date:9/28/2015)... 28, 2015 Synaptics Inc. (NASDAQ: SYNA ... announced that Lenovo has selected Synaptics , Natural ... its latest smartphone, the Vibe P1. The new ... the device and provide swift access to applications and ... Natural ID FS4202 sensor solution utilizes AES256-bit encryption of ...
(Date:9/24/2015)... 2015  EyeLock LLC, a market leader of iris-based ... and latest technology in Booth #602 at next week,s ... EyeLock,s iris authentication technology provides an unprecedented ... making it the most proven way to authenticate one,s ... to deliver a fast and friendly user experience to ...
(Date:9/10/2015)... 2015 This report provides detailed descriptions of ... and emerging sensor types that will dominate in the ... of the wearable technology hype curve in the last ... common feature with all of them is the prominence ... most useful functions. Sensors collect data about the physical ...
Breaking Biology News(10 mins):
(Date:10/11/2015)... ... October 11, 2015 , ... Intelligent Implant ... officially launched and multiple surgeries have been completed with this new posterior thoracolumbar ... Neuroscience & Spine Center of the Carolinas. The Revolution™ Spinal System pioneers ...
(Date:10/9/2015)... 9, 2015 Governor Tom Wolf ... company focused on developing T-cell receptor cancer immunotherapy treatments, ... a new expansion project. Pennsylvania ... commonwealth as 110 new, high-paying jobs will be created ... "My budget proposal includes sustained funding for the life ...
(Date:10/9/2015)... ... October 09, 2015 , ... From blood to food to ... cells from their surroundings for research, diagnostics, and cell therapy—also known as cell ... Ann Arbor-based startup Akadeum Life Sciences is developing a radically new ...
(Date:10/8/2015)... Oct. 8, 2015  Sorrento Therapeutics, Inc. (NASDAQ: ... treatments for cancer and associated pain, announced today that ... be presenting at the Aegis Capital Corporation 2015 ... :Event:Aegis Capital Corporation 2015 Growth ConferenceDate:Friday, October 9, ... Encore @ The Wynn in Las Vegas, NV ...
Breaking Biology Technology: