Navigation Links
Workman Lab characterizes novel regulator of chromosome function
Date:3/10/2008

The Stowers Institute's Workman Lab has shed new light on a novel histone acetyltransferase protein complex called ATAC. Acetyltransferases are enzymes that introduce a new acetyl functional group into histone proteins, a process by which all chromosome functions are controlled.

The findings were posted to the Web site of Nature Structural and Molecular Biology yesterday and will appear in a future print edition of the journal.

ATAC is unique as the only acetyltransferase protein complex that contains two distinct acetyltransferase enzymes; one that generally activates processes like gene transcription and DNA repair and another that makes a specific modification thought to alter chromosome structure. ATAC can also assist in the movement of chromosome subunits, called nucleosomes, along DNA.

The work was conducted using the Drosophila, or fruit fly, model ATAC is present in multicellular organisms, including fruit flies and humans, but not in lower eukaryotes, like yeast.

We knew that the ATAC complex existed and that it was only present in multicellular organisms, but we did not know all the proteins it contained or what their functions were, said Tamaki Suganuma, Ph.D., Postdoctoral Research Associate and first author on the paper. In this work, we were able to identify the protein components of ATAC to gain insight into its functions.

The improved understanding of ATAC may lead to a better understanding of a number of human diseases.

We were able to show that in Drosophila, the ATAC complex is essential for development of the embryo to an adult organism, said Jerry Workman, Ph.D., Investigator and senior author on the publication. It is likely that ATAC will also be required for development of mammals, including humans, and that by understanding the functions of ATAC we will be better able to pinpoint its role in developmental defects and cancers. Having characterized all of the proteins in ATAC, the Workman Lab will now focus on which chromosomal functions it regulates and how these actions contribute to development.


'/>"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Related biology news :

1. Trainor Lab characterizes gene essential for prenatal development of nervous system
2. Xie Lab characterizes niche control of stem cell function
3. Scientists uncover a novel mechanism that regulates carbon dioxide fixation in plants
4. NIA uses Genomatix in stem cell research, suggests novel transcription factors for stemness
5. UDs Bobev receives NSF Early Career Award for research on novel compounds of rare Earth metals
6. Scientists outline novel approach to ecosystem management
7. Systems biologist finds novel solutions to fundamental biological problems
8. Ingram Micro to Distribute New Fujitsu Biometric Login Products for Novell eDirectory in United States
9. Novel mechanism for long-term learning identified by Carnegie Mellon researchers
10. New drug targets may fight tuberculosis and other bacterial infections in novel way
11. Feinstein researchers develop new genetic method and identify novel genes for schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. ... have received the prestigious international IAIR Award for the most innovative ... ... Maldives Immigration ... Algeen (small picture on the right) have received the IAIR award for ...
(Date:3/22/2017)... VILNIUS, Lithuania , March 21, 2017 /PRNewswire/ ... identification and object recognition technologies, today announced the ... development kit (SDK), which provides improved facial recognition ... safety cameras on a single computer. The new ... algorithms to improve accuracy, and it utilizes a ...
(Date:3/20/2017)... -- PMD Healthcare announces the release of its new ... (WMS), a remote, real-time lung health monitoring and management ... a Medical Device, Digital Health, and Chronic Care Management ... solutions that empower people to improve their healthcare and ... the first ever personal spirometer, Spiro PD, which was ...
Breaking Biology News(10 mins):
(Date:6/20/2017)... 20, 2017  Kibow Biotech Inc., a pioneer in ... issuance of a new patent covering a unique method ... U.S. Patent and Trademark Office on May 23 rd ... Buzz of Bio award in 2014 in ... non-drug approaches to chronic disease. Renadyl™, the first and ...
(Date:6/19/2017)... ... June 19, 2017 , ... As Vice President, Product Services, ... training, implementation, support, and client process and SOP development. , Mr. Guinter brings ... leadership roles for service providers and top-tier pharmaceuticals, and as an independent consultant ...
(Date:6/16/2017)... ... June 16, 2017 , ... Cognition Corporation , ... two more sessions of its “From the Helm” Webinar Series. , The ... online templates for design control exercises. Led by David Cronin, Cognition’s CEO, the ...
(Date:6/15/2017)... ... June 15, 2017 , ... Cybrexa ... Series B round of financing in the amount of $6 million. An investment ... participated in the round. , The Series B funding will enable Cybrexa to ...
Breaking Biology Technology: