Navigation Links
Workman Lab characterizes novel regulator of chromosome function
Date:3/10/2008

The Stowers Institute's Workman Lab has shed new light on a novel histone acetyltransferase protein complex called ATAC. Acetyltransferases are enzymes that introduce a new acetyl functional group into histone proteins, a process by which all chromosome functions are controlled.

The findings were posted to the Web site of Nature Structural and Molecular Biology yesterday and will appear in a future print edition of the journal.

ATAC is unique as the only acetyltransferase protein complex that contains two distinct acetyltransferase enzymes; one that generally activates processes like gene transcription and DNA repair and another that makes a specific modification thought to alter chromosome structure. ATAC can also assist in the movement of chromosome subunits, called nucleosomes, along DNA.

The work was conducted using the Drosophila, or fruit fly, model ATAC is present in multicellular organisms, including fruit flies and humans, but not in lower eukaryotes, like yeast.

We knew that the ATAC complex existed and that it was only present in multicellular organisms, but we did not know all the proteins it contained or what their functions were, said Tamaki Suganuma, Ph.D., Postdoctoral Research Associate and first author on the paper. In this work, we were able to identify the protein components of ATAC to gain insight into its functions.

The improved understanding of ATAC may lead to a better understanding of a number of human diseases.

We were able to show that in Drosophila, the ATAC complex is essential for development of the embryo to an adult organism, said Jerry Workman, Ph.D., Investigator and senior author on the publication. It is likely that ATAC will also be required for development of mammals, including humans, and that by understanding the functions of ATAC we will be better able to pinpoint its role in developmental defects and cancers. Having characterized all of the proteins in ATAC, the Workman Lab will now focus on which chromosomal functions it regulates and how these actions contribute to development.


'/>"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Related biology news :

1. Trainor Lab characterizes gene essential for prenatal development of nervous system
2. Xie Lab characterizes niche control of stem cell function
3. Scientists uncover a novel mechanism that regulates carbon dioxide fixation in plants
4. NIA uses Genomatix in stem cell research, suggests novel transcription factors for stemness
5. UDs Bobev receives NSF Early Career Award for research on novel compounds of rare Earth metals
6. Scientists outline novel approach to ecosystem management
7. Systems biologist finds novel solutions to fundamental biological problems
8. Ingram Micro to Distribute New Fujitsu Biometric Login Products for Novell eDirectory in United States
9. Novel mechanism for long-term learning identified by Carnegie Mellon researchers
10. New drug targets may fight tuberculosis and other bacterial infections in novel way
11. Feinstein researchers develop new genetic method and identify novel genes for schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2016)... , March 31, 2016 ... ) ("LegacyXChange" or the "Company") LegacyXChange is ... users of its soon to be launched online site ... https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide potential shareholders ... of DNA technology to an industry that is notorious ...
(Date:3/23/2016)... , March 23, 2016 ... erhöhter Sicherheit Gesichts- und Stimmerkennung mit Passwörtern ... (NASDAQ: MESG ), ein führender ... das Unternehmen mit SpeechPro zusammenarbeitet, um erstmals ... Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, im Rahmen ...
(Date:3/21/2016)... Unique technology combines v ... security   Xura, Inc. ... digital communications services, today announced it is working alongside ... customers, particularly those in the Financial Services Sector, the ... within a mobile app, alongside, and in combination with, ...
Breaking Biology News(10 mins):
(Date:5/20/2016)... ... May 20, 2016 , ... Korean researchers say Manumycin ... may offer a new way to treat the disease. Surviving Mesothelioma has just posted ... , Scientists from several Korean institutions based their mesothelioma study on the fact the ...
(Date:5/19/2016)... RIDGE, British Columbia , May 19, 2016 ... AdvanTec Global Innovations Inc. (AGI), based out of ... recently added Greenlane Biogas Ltd. to its existing ... 2-year contract manufacturing agreement. AFS along with its ... Technologies (ABT) is a vertically integrated industrial group ...
(Date:5/19/2016)... Regen BioPharma, Inc ... announced today initiation of a preclinical development program ... cancer immunotherapeutic product leveraging its NR2F6 immunological checkpoint. ... generation of cord blood derived killer cells whose ... product in development will be a "universal donor" ...
(Date:5/18/2016)... ... May 18, 2016 , ... Shimadzu Scientific Instruments announces ... of Toledo. This two-day camp will take place annually starting June 2016. It ... pharmaceutical sciences in preparation for a university academic program. , The laboratory- ...
Breaking Biology Technology: