Navigation Links
Workman Lab characterizes novel regulator of chromosome function
Date:3/10/2008

The Stowers Institute's Workman Lab has shed new light on a novel histone acetyltransferase protein complex called ATAC. Acetyltransferases are enzymes that introduce a new acetyl functional group into histone proteins, a process by which all chromosome functions are controlled.

The findings were posted to the Web site of Nature Structural and Molecular Biology yesterday and will appear in a future print edition of the journal.

ATAC is unique as the only acetyltransferase protein complex that contains two distinct acetyltransferase enzymes; one that generally activates processes like gene transcription and DNA repair and another that makes a specific modification thought to alter chromosome structure. ATAC can also assist in the movement of chromosome subunits, called nucleosomes, along DNA.

The work was conducted using the Drosophila, or fruit fly, model ATAC is present in multicellular organisms, including fruit flies and humans, but not in lower eukaryotes, like yeast.

We knew that the ATAC complex existed and that it was only present in multicellular organisms, but we did not know all the proteins it contained or what their functions were, said Tamaki Suganuma, Ph.D., Postdoctoral Research Associate and first author on the paper. In this work, we were able to identify the protein components of ATAC to gain insight into its functions.

The improved understanding of ATAC may lead to a better understanding of a number of human diseases.

We were able to show that in Drosophila, the ATAC complex is essential for development of the embryo to an adult organism, said Jerry Workman, Ph.D., Investigator and senior author on the publication. It is likely that ATAC will also be required for development of mammals, including humans, and that by understanding the functions of ATAC we will be better able to pinpoint its role in developmental defects and cancers. Having characterized all of the proteins in ATAC, the Workman Lab will now focus on which chromosomal functions it regulates and how these actions contribute to development.


'/>"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Related biology news :

1. Trainor Lab characterizes gene essential for prenatal development of nervous system
2. Xie Lab characterizes niche control of stem cell function
3. Scientists uncover a novel mechanism that regulates carbon dioxide fixation in plants
4. NIA uses Genomatix in stem cell research, suggests novel transcription factors for stemness
5. UDs Bobev receives NSF Early Career Award for research on novel compounds of rare Earth metals
6. Scientists outline novel approach to ecosystem management
7. Systems biologist finds novel solutions to fundamental biological problems
8. Ingram Micro to Distribute New Fujitsu Biometric Login Products for Novell eDirectory in United States
9. Novel mechanism for long-term learning identified by Carnegie Mellon researchers
10. New drug targets may fight tuberculosis and other bacterial infections in novel way
11. Feinstein researchers develop new genetic method and identify novel genes for schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/4/2017)... , Jan. 4, 2017  CES 2017 – ... biometric sensor technology, today announced the launch of ... sensor systems, the highly-accurate biometric sensor modules that ... biometric technology, experience and expertise. The two new ... designed specifically for hearables, and Benchmark BW2.0, a ...
(Date:12/20/2016)... RALEIGH, N.C. and GENEVA, Dec, 20, 2016 ... performance biometric data sensor technology, and STMicroelectronics ... across the spectrum of electronics applications, announced today ... scalable development kit for biometric wearables that includes ... integrated with Valencell,s Benchmark™ biometric sensor ...
(Date:12/15/2016)... VANCOUVER, Canada and BADEN-BADEN, Germany ... Solutions, a leading global financial services provider, today announced an ... in passive behavioural biometrics, to join forces. The partnership will ... fraud mitigation strategies in compliance with local data protection regulation. ... In ...
Breaking Biology News(10 mins):
(Date:1/17/2017)... YORK , Jan. 17, 2017 ... grow at a CAGR of around 7.5% over ... by 2025. Some of the prominent trends that ... growing incidences of diseases & graft transplant surgeries ... on Material the market is categorized into immunomodulatory ...
(Date:1/17/2017)... Mass. , Jan. 17, 2017   Pulmatrix, ... stage biopharmaceutical company developing innovative inhaled therapies to address ... for treating fungal infections in the lungs of CF ... Disease Product" (QIDP) by the U.S. Food & Drug ... which is designed to speed the development of novel ...
(Date:1/17/2017)... MANHASSET, N.Y. , Jan. 17, 2017 /PRNewswire-USNewswire/ ... to speed the advance of precision cancer research. ... State,s largest health care provider, Northwell ... each year. Indivumed, GmbH is a ... individualize anti-cancer medical therapies. Together they will greatly ...
(Date:1/17/2017)... ... January 17, 2017 , ... ... global provider of learning and performance management systems for high-consequence industries, announced today ... , “In the life sciences industry, organizations must pay much more attention to ...
Breaking Biology Technology: