Navigation Links
Work with power grids leads to cell biology discovery
Date:3/17/2008

along the cellular network, said Motter, whose interest and expertise lie in complex systems and understanding how the structure and dynamics of a high-dimensional system, such as an intracellular network or a power grid, relate to its function.

Our recent research shows that what is true in power networks is also true in biological networks. Inflicting a small amount of damage can control what otherwise would be much more significant damage.

With the experimental information assembled, the researchers used their computer model to simulate the organism and its function. They started with a perfect cell and then, with a key gene deletion, damaged the cell so that it was unable to grow or had a significantly reduced growth rate.

Next, the researchers restored growth by deleting additional genes, which stimulated the cell to make a different choice and use different pathways. Interestingly, the cells recovery was stronger when more genes were deleted. They could even restore growth to non-growing mutant cells; the researchers dubbed this the Lazarus effect.

Our research is based on optimizing the use of resources already available in the cell, said Motter. We are exploring existing reactions and genes in the cell that the cell would not use or use to a lesser degree under normal conditions. This is different from traditional gene therapy, which is based on introducing new genes into the cell -- with its own advantages and problems because of that.

The teams use of predictive models is similar to how physicists use models, for example, to determine the position of the moon tomorrow at a specific time. Thanks to the recent wealth of available biological information, computational scientists now are beginning to develop quantitative models of biological systems that allow them to predict cellular behavior.

In one in silico experiment (via computer simulation) with E. coli, the researchers found that the deletion of on
'/>"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New twist on lifes power source
2. U of I researcher develops power-packed soy breakfast cereal
3. Genetic tags reveal secrets of memories staying power in mice
4. Powerful yet reliable proteomics techniques are the focus of a new methods book
5. Gene discovery made easier with powerful new networking technique
6. Department of Energy putting power in the hands of consumers through technology
7. There is powerful evidence of evolution in human DNA
8. Blood pressure drug telmisartan shows powerful activity against stroke
9. Wind power explored off Californias coast
10. Smarter energy storage for solar and wind power
11. The power of multiples: Connecting wind farms can make a more reliable - and cheaper - power source
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Inc. , a market leader of iris-based identity authentication solutions, ... the new role of Senior Vice President of Mobile and ... platforms and wearable solutions for EyeLock,s technologies. Gerber brings more ... industry to his role at EyeLock, with expertise in human ...
(Date:12/22/2014)... , Dec. 22, 2014  The 2014 Holiday Season ... as Acuity Market Intelligence reports that the long anticipated ... forecasts that intensifying demand for smart phones, tablets, and ... global market of 2.5 billion users with nearly 4.8 ...
(Date:12/17/2014)... and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ) has announced ... Home Button Synaptics Fingerprint Sensor Technology Analysis" report ... Based on a totally different sensing ... first time a fingerprint sensor in its product. ...
Breaking Biology News(10 mins):EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 2First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2
... Conn. A missing link in the evolution of the ... with the discovery of a 390 million-year-old fossil by researchers ... specimen, named Schinderhannes bartelsi , was found fossilized in ... that yields spectacularly durable pyrite-preserved fossils findings collectively known ...
... of a new species of fruit fly--and the sequential development ... of the journal Science . Jeff Feder, a ... introduction of apples to America almost 400 years ago ultimately ... to its modification and the subsequent modification of a parasitic ...
... the National Science Foundation (NSF) will host its 8th ... This year,s forum focuses on ecological connectivity and climate. ... an ecological context, connectivity is defined as the transfer ... animals among interconnected locations. In this symposium, LTER ...
Cached Biology News:Origin of claws seen in 390-million-year-old fossil 2Researchers observe evolution chain reaction 2National Science Foundation forum to address ecological connectivity and climate in a changing world 2
(Date:1/22/2015)... 22 de enero de 2015  El Dr. Paul ... llamada a nominaciones para 2015. Este prestigioso premio reconoce ... tiene el potencial para hacer, contribuciones destacadas para la ... hasta el 15 de marzo de 2015 a través ...
(Date:1/22/2015)... , Jan. 22, 2015  Derma Sciences, Inc. ... company focused on advanced wound care, announces that ... tissues, have been added to the Premier, Inc. ... the opportunity for the AMNIOEXCEL® and AMNIOMATRIX® product ...
(Date:12/24/2014)... 2014  Vermillion, Inc. (Nasdaq:   VRML), a bio-analytical ... that the Company closed its previously announced private ... Jack W. Schuler , Birchview Fund LLC and ... before offering expenses.  The proceeds will be used ...
(Date:12/24/2014)... Earlier this year in a June 24 international ... Stem Cell Technology Center, LLC ( ASCTC ) focused attention ... adult tissue stem cells. His title “Asymmetric Self-Renewal by ... Future,” embodied the essence of his message to congress participants. ...
Breaking Biology Technology:El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4
... on Known Therapeutic Benefits of Unsaturated Fatty Acids in ... ... Amarin Corporation plc,(NASDAQ: AMRN ) today announced that it ... therapeutic benefits of,unsaturated fatty acids in cardiovascular disease. Amarin plans ...
... "We Want to Double our Sales Within Three Years", ... in,sales of EUR 3.4 million to EUR 17 million, ... the path of significant growth in 2007. "We want ... years," states CEO Nikolaus Uleer.,With the construction of the ...
... For Hispanic-Americans without health,insurance, it can be ... and prescription medicines. However, help is available for ... their doctors. Listen to this report from ... Registered journalists can access video, audio, text, ...
Cached Biology Technology:Amarin Announces Initiation of Cardiovascular Development Strategy 2Amarin Announces Initiation of Cardiovascular Development Strategy 3Amarin Announces Initiation of Cardiovascular Development Strategy 4Amarin Announces Initiation of Cardiovascular Development Strategy 5Dr. Suwelack Skin & Health Care: New Product in the FDA Certification Process 2
The Piezo Power MicroDissection (PPMD) system is designed for rapid isolation of single cells or small cell areas...
... Kits overcome this limitation and offer high ... range in low-density protein array (96- and ... ideal for performing reverse-phase protein arrays and ... presence of low abundant antigens. Protein Detector ...
... Cassettes facilitate the hybridization of DNA or ... 25mm x 75mm glass slides. The proprietary ... correct for poor flatness, as is often ... low volume chamber (67uL analytical cavity volume) ...
... binding is a problem in your ... immobilized NeutrAvidin products as superior alternatives ... a modified avidin derivative that combines ... biotin-binding protein with exceptionally low nonspecific ...
Biology Products: