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Work in mice will contribute to the study of hereditary diseases that lead to blindness
Date:7/8/2009

This release is available in Spanish.

Researchers of the University of Granada (Spain) have used a technique consisting of the induction of neuronal degeneration neuronal for intense light exposure in the mouse's retina that will be helpful for the study of retinitis pigmentosa (RP), a group of hereditary diseases which lead to blindness and affect more than one million persons a year all over the world. In addition, the results of this research work could be very useful for the detection of new factors or molecules originated by microglial cells and related to degenerative processes of the retina.

The doctoral thesis of Ana Mara Santos Carro, researcher of the Department of Cell Biology of the University of Granada, is based on the study of microglial cells, a type of cell of the Nervous System that develop a phagocytic or purifying role against damages or infections in such system. Her work has analysed the distribution of microglial cells in la retina of the mouse during all its development, both embryonic and postnatal and adult, and has studied the response of these cells to a neurodegenerative process induced in the retina by intense light exposure.

Parkinson and Alzheimer

The researcher of the UGR insists that "it is important to get to know the response of the microglial cells against neurodegenerative, because such cells are practically involved in all the diseases and damages of the nervous system, including Parkinson and Alzheimer, and knowing their behaviour in pathologic situations could be helpful in the design of therapeutic strategies".

Microglial cells are the resident population of macrophages in the central nervous system (CNS) and play a relevant role in the immune defence. The research group of the UGR "Embryology of the Nervous System" has been studying for years
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Contact: Ana Mara Santos Carro
asantos@ugr.es
34-958-243-232
University of Granada
Source:Eurekalert  

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Work in mice will contribute to the study of hereditary diseases that lead to blindness
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