Navigation Links
'Work environment' affects protein properties
Date:7/3/2014

menon. In a crowded lift or on a crowded train, everybody attempts to avoid direct contact with their neighbours and to assume as compact a posture as possible (e.g. by tucking in their arms). According to the excluded volume theory, the principle of mutual repulsion can be applied to proteins in a densely-packed cellular environment. They assume a compact structure. As a rule, their biologically active status is at the same time their most compact status, which is why the excluded volume theory predicts a stabilisation of the biologically active status.

The study demonstrates that there are more factors at work than just mutual repulsion

Deploying various solvent additives, such as biomacromolecules, sugars and salts, the RUB researchers have imitated various cellular conditions and analysed the way they affect the model protein ubiquitin. They demonstrated that the proteins' behaviour is affected by more than just mutual repulsion between protein and solvent additive. In thermodynamic studies, different stabilisation and destabilisation mechanisms were discovered. Contrary to the expected so-called entropic stabilisation based on the excluded volume effect the researchers observed a so-called enthalpic stabilisation of ubiquitin in the presence of macromolecules, sugars and salts. Enthalpic stabilisation is directly correlated to the strengthening of the chemical bonds in the biologically active status and cannot be explained away with the protein's more compact shape being purely volume-based.

Water as mediator between protein and dissolved substances

The researchers attribute the enthalpic stabilisation phenomenon to a water-mediated process: protein and solvent additive do not interact directly, but following a modification of the water properties of the solvent additives' hydration water, the hydrogen bridge bonds in the protein's biologically active status are optimised. The project was financed by the Returnee Programme o
'/>"/>

Contact: Dr. Simon Ebbinghaus
simon.ebbinghaus@rub.de
49-234-322-5533
Ruhr-University Bochum
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Alcohol use disorders linked to decreased work trajectory
2. NYSCF and eagle-i Network co-develop iPS cell database
3. Urban Water Management Workshop stresses more collaboration and innovation
4. Celebrating the work of a neglected scientific pioneer
5. NYU and UCSF researchers develop a framework for monitoring oral cancer
6. Three gene networks discovered in autism, may present treatment targets
7. UH chemists work could impact disease management, treatments
8. PARTNERS works to promote tropical forest regrowth
9. Online network connects honeybee keepers and researchers
10. Quadrapeutics works in preclinical study of hard-to-treat tumors
11. Delegating the dirty work is a key to evolution
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Work environment' affects protein properties
(Date:7/21/2015)... , July 21, 2015  NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile ... wallet, announces that it has filed provisional patent ... Method. This invention highlights next ... authorizes an account, but also the user using ...
(Date:7/20/2015)... , July 20, 2015  Acuity Market Intelligence,s ... The Convergence of Commerce and Privacy" forecasts that ... biometric apps will be downloaded to smart mobile ... mobile biometrics market is projected to generate more ... during the seven-year forecast period.    ...
(Date:7/13/2015)... OXFORD, Conn. , Jul. 13, 2015 /PRNewswire/ ... the "Company"), a biometric authentication company focused on ... it has filed provisional patent 62/188684 for ... NXT-ID achieves another new convenient and secure method ... expands new, innovative payment methods, introduced with its ...
Breaking Biology News(10 mins):NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 2NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 3NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 4Biometrics on Smart Mobile Devices to Redefine Digital Identity with 12.9 Billion Biometric App Downloads between 2014 and 2020 2NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4
... major study sheds new light on the role of carbon ... indicates that instead of sinking, carbon dioxide is often consumed ... a dimly lit area 100 to 1,000 meters below the ... where it can be stored and prevented from re-entering the ...
... from preterm birth are staggering. In Canada, outlays for ... be almost $2 billion per year. In a 5-year, ... to mothers who had entered premature labor led to ... the study are reported in the January issue of ...
... New predictions about bird flu, involving the use of ... antiviral drugs might be the best way to deal ... has not triggered a worldwide human epidemic yet because ... this ability, it would take 6-8 months to develop ...
Cached Biology News:Ocean's 'twilight zone' may be a key to understanding climate change 2
(Date:7/29/2015)... , July 29, 2015 /PRNewswire/ - BioAmber Inc. (NYSE: ... the Company,s Chief Financial Officer has resigned.  The Company ... Financial Officer who retired in December 2014, as full ... a permanent successor.     Andy Ashworth ... and ensure a smooth transition.  Andy was the Company,s ...
(Date:7/29/2015)... 29, 2015 Research ... addition of the "Global Biosimilars Market, 2015 ... The Global Biosimilars Market, 2015 - 2025, ... growing biosimilars market. With the blockbuster biologics losing ... costs, biosimilars are being viewed as viable substitutes ...
(Date:7/29/2015)... , July 29, 2015  Pfenex Inc. (NYSE MKT: ... results will be released on Thursday, August 13, 2015, ... Time, Pfenex management will host a conference call to ... A press release outlining the financial results and business ... Please call 1-866-376-8058 (US) or 1-412-542-4131 (international) ...
(Date:7/29/2015)... , July 29, 2015 /PRNewswire/ - Aeterna Zentaris ... announced it has selected an optimized Erk inhibitor ... in the development of a new class of ... pathway represents a prime target for therapeutic intervention ... activities and survival benefits for B-Raf and Mek ...
Breaking Biology Technology:BioAmber Announces Change in Chief Financial Officer 2BioAmber Announces Change in Chief Financial Officer 3Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 2Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 3Pfenex To Report Second Quarter 2015 Results and Provide Business Update on Thursday, August 13, 2015 2Aeterna Zentaris Announces Optimized Erk Inhibitor Compounds For Further Development 2Aeterna Zentaris Announces Optimized Erk Inhibitor Compounds For Further Development 3
... Wisconsin's research and development funding has exceeded expectations, reaching $3.6 billion ... a target of $3.3 billion by 2005. , ,In 2002, ... per capita, and 13 th in academic R&D spending. ... growth rate in R&D the last few years," said David Ward, ...
... at Chippewa Valley Technical College in Eau Claire are ... micro-level surface analysis to firms or organizations with an ... says three students will comprise each of five teams ... believes that firms considering the purchase of an electron ...
... Wireless Facilities, Inc. , a global ... communication networks, technology networks and security systems, announced today ... and deployment services for the City of Madison, Wisconsin's ... company Cellnet, and in coordination with Madison Gas & ...
Cached Biology Technology:New report says Wisconsin R&D spending exceeding expectations 2
... HEEBO (Human Exonic Evidence Based Oligonucleotide) Genome ... Oligonucleotide ) Genome Set contain a collection ... from constitutively expressed exons, allowing interrogation of ... leading researchers at Stanford University and UCSF, ...
Rabbit polyclonal to XPC ( Abpromise for all tested applications). Antigen: Synthetic peptide from N-terminus of Human XPC conjugated to a carrier protein Entrez Gene ID: 7508 Swiss ...
Rabbit polyclonal to NIRF ( Abpromise for all tested applications). Antigen: Synthetic peptide derived from residues 186-235 of human NIRF. Entrez Gene ID: 115426 Swiss Protein ID: Q96PU...
...
Biology Products: