Navigation Links
'Work environment' affects protein properties
Date:7/3/2014

Under the tutelage of Junior Professor Dr Simon Ebbinghaus, researchers from Bochum have demonstrated that the water surrounding the dissolved substances inside the cell plays a crucial role with regard to protein stability, which has frequently been neglected in the past. The researchers have published the results of their study, gained by means of simple model systems and thermodynamic analyses, in the Journal of the American Chemical Society (JACS). The results have been obtained following a collaboration under the umbrella of the Excellence Cluster RESOLV. The researchers were, moreover, presented with a Hot Topic Poster Award at this year's Bunsentagung in Hamburg.

Proteins' work environment more viscous than egg white

Proteins are among the most important and most-studied biomolecules in biochemical research. They fulfil structure-relevant tasks and are the cells' molecular machines: catalysing chemical reactions, transporting metabolic products and identifying metabolites. Consequently, deficiencies of protein function often result in severe disorders, e.g. Huntington's and Alzheimer's disease. The proteins' natural work environment inside the cell is a highly crowded solution (more viscous and more highly concentrated than egg white), consisting of various macromolecules as well as small organic and inorganic substances. In order to study protein function using modern analytical methods, researchers often purify proteins in vitro and study them in diluted aqueous solution. However, it often cannot be precisely ascertained to what extent the experimental results reflect the actual function within the cellular environment.

Theory: in narrow spaces, proteins "tuck in their elbows"

A method frequently used for predicting the effect a densely-packed cellular environment has on proteins is the so-called excluded volume theory. It can be best explained using the example of an everyday pheno
'/>"/>

Contact: Dr. Simon Ebbinghaus
simon.ebbinghaus@rub.de
49-234-322-5533
Ruhr-University Bochum
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Alcohol use disorders linked to decreased work trajectory
2. NYSCF and eagle-i Network co-develop iPS cell database
3. Urban Water Management Workshop stresses more collaboration and innovation
4. Celebrating the work of a neglected scientific pioneer
5. NYU and UCSF researchers develop a framework for monitoring oral cancer
6. Three gene networks discovered in autism, may present treatment targets
7. UH chemists work could impact disease management, treatments
8. PARTNERS works to promote tropical forest regrowth
9. Online network connects honeybee keepers and researchers
10. Quadrapeutics works in preclinical study of hard-to-treat tumors
11. Delegating the dirty work is a key to evolution
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Work environment' affects protein properties
(Date:4/17/2015)... Increasing adoption in ... to drive biometric systems market in ... According to a recently released TechSci Research ... biometric systems market in Saudi Arabia ... CAGR of over 22% through 2020. The market ...
(Date:4/14/2015)...  HYPR Corp. today announced it has joined ... tm , an industry consortium transforming online authentication ... technology and collaborate to deliver open specifications for ... and private, and easier to use. ... sensitive user information and eliminates the dependency on ...
(Date:4/14/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market, announces that its Wocket® smart ... Design Awards under the category  ,Product Design – Technology,. ... are part of a global multi-disciplinary awards program. The ... marketplace, industry and judging panel. Winners will be announced ...
Breaking Biology News(10 mins):Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3
... latest research discoveries on diabetes, obesity, endocrine-disrupting chemicals, adolescent health ... press conferences at ENDO 2013: The 95th Annual Meeting & ... Saturday, June 15 Adolescent Health ... used to help teens with conditions including eating disorders and ...
... 2013The Roy J. Carver Charitable Trust has awarded a ... at the University of Illinois at Urbana-Champaign. Under the ... Investigator Dr. Christopher Rao, the grant will be disbursed ... for a new research theme devoted to the new ...
... oceans absorb about 25 percent of the carbon dioxide ... they have taken up about half of the man-made ... seen with the naked eye, make this valuable service ... seawater, various species convert it to organic carbon and ...
Cached Biology News:Roy J. Carver Charitable Trust funds new research focus at Institute for Genomic Biology 2Fast-sinking jellyfish could boost the oceans' uptake of carbon dioxide 2Fast-sinking jellyfish could boost the oceans' uptake of carbon dioxide 3
(Date:4/16/2015)... DIEGO , April 16, 2015 Avelas ... dedicated to improving cancer surgeries, announced today that it ... fluorescent cancer illuminator, AVB-620, in women with primary, non-recurrent ... the company also welcomed the addition of Steven ... The open label, dose escalation study will ...
(Date:4/16/2015)... Switzerland , April 16, 2015 /PRNewswire/ ... Debiopharm Group ™ , a Swiss-based global biopharmaceutical ... medical needs as well as companion diagnostics, ... investigational compounds Debio 1143 (SMAC mimetic) and Debio 1347/CH5183284 ... the 2015 Annual meeting of the American Association for Cancer Research ...
(Date:4/16/2015)... NJ (PRWEB) April 16, 2015 ... Dr. Joseph V. Gulfo to become the Executive ... Entrepreneurship. Simultaneously, FDU announced the kick-off of the ... program spearheaded by Dr. Gulfo, under the Rothman ... College of Business) and in collaboration with FDU’s ...
(Date:4/16/2015)... 2015 Dana-Farber Cancer Institute and ... Resolution Bioscience, Inc. today announced the successful completion ... blood-based, clinic ready, Next Generation Sequencing (NGS) assay ... is the first to demonstrate the successful sequencing ... in blinded plasma samples and highlights the ability ...
Breaking Biology Technology:Avelas Biosciences Initiates Phase 1b Trial of AVB-620 in Breast Cancer Patients 2Avelas Biosciences Initiates Phase 1b Trial of AVB-620 in Breast Cancer Patients 3Debiopharm International SA Announces Results of 2 Key Oncology Programs at 2015 AACR Conference 2Debiopharm International SA Announces Results of 2 Key Oncology Programs at 2015 AACR Conference 3Dr. Joseph V. Gulfo Named Executive Director of Fairleigh Dickinson University’s Rothman Institute to Spearhead New Initiative for Patient-Centered Innovation (iPCI) 2Dr. Joseph V. Gulfo Named Executive Director of Fairleigh Dickinson University’s Rothman Institute to Spearhead New Initiative for Patient-Centered Innovation (iPCI) 3Resolution Bioscience announces successful collaboration on a novel, non-invasive, targeted NGS test for lung cancer 2Resolution Bioscience announces successful collaboration on a novel, non-invasive, targeted NGS test for lung cancer 3
... 2011 RiverVest Venture Partners®, a venture capital ... companies, today announced that John McKearn, Ph.D., has ... Dr. McKearn joined RiverVest as Venture Partner in ... pharmaceutical research and development as former president and ...
... 3, 2011 Cynosure, Inc. (NASDAQ: CYNO ) today ... Revenues for the first quarter of 2011 increased ... period of 2010.   Net loss for the first quarter of ... compared with a net loss of $2.8 million, or $0.22 per ...
... MAP Pharmaceuticals, Inc. (Nasdaq: MAPP ) today announced ... The net income for the first quarter ended ... loss of $14.1 million during the same period in 2010. ... was related primarily to the $34.2 million in collaboration revenue ...
Cached Biology Technology:John McKearn, Ph.D., Promoted to Managing Director of RiverVest Venture Partners 2Cynosure Reports Financial Results for the First Quarter of 2011 2Cynosure Reports Financial Results for the First Quarter of 2011 3Cynosure Reports Financial Results for the First Quarter of 2011 4Cynosure Reports Financial Results for the First Quarter of 2011 5Cynosure Reports Financial Results for the First Quarter of 2011 6MAP Pharmaceuticals Reports First Quarter of 2011 Financial Results 2MAP Pharmaceuticals Reports First Quarter of 2011 Financial Results 3MAP Pharmaceuticals Reports First Quarter of 2011 Financial Results 4MAP Pharmaceuticals Reports First Quarter of 2011 Financial Results 5
Mouse Ameloblastin Biotinylated Affinity Purified PAb ENTREZ GeneID: 11698...
Human SOST Affinity Purified Polyclonal Ab...
Homo sapiens CDC23 (cell division cycle 23, yeast, homolog),...
Human FADD Affinity Purified Polyclonal Ab...
Biology Products: