Navigation Links
Women's heart disease tied to small blood vessels
Date:10/14/2011

Bethesda, Md. Heart disease affects men and women in different ways. In women, symptoms of burgeoning heart disease are often more insidious, but when a heart attack strikes, it is more lethal than it is in men. Roughly 25 percent of men will die within a year of their first heart attack, but among women, 38 percent will die. Women are twice as likely as men to have a second heart attack within 6 years of their first one, and women are twice as likely as men to die after bypass surgery.

Yet after a heart attack, women's hearts are more likely to maintain their systolic functiontheir ability to contract and pump blood from the chambers into the arteries. According to C. Noel Bairey Merz, MD, Director of the Women's Heart Center at Cedars-Sinai Heart Institute in Los Angeles, this suggests that heart disease manifests differently in women, affecting the microvasculature (small blood vessels) instead of the macrovasculature (major blood vessels) as it does in men.

Dr. Bairey Merz will provide an overview of the sex differences in heart disease at the Physiology of Cardiovascular Disease: Gender Disparities conference, October 12 at the University of Mississippi in Jackson. The conference is sponsored by the American Physiological Society with additional support from the American Heart Association. Dr. Bairey Merz will give her presentation, "Ischemic Heart Disease in Women: Microvascular Coronary Dysfunction," on Friday, Oct. 14.

Function Indicates Form

The heart is a muscle, and as with other muscles, depriving it of oxygen causes damage that diminishes its ability to function. Conventional wisdom notes that the most prevalent form of heart disease is coronary artery disease, in which atherosclerotic plaque narrows and eventually blocks the major arteries leading into the heart, thus cutting off the heart's supply of oxygen. The damage to the heart tends to be permanent, and after a heart attack, the heart never quite regains its former power.

But when reviewing the medical literature, Dr. Bairey Merz and her colleagues found that women's hearts were less likely than men's to lose their ability to pump blood after a heart attack, and that female heart patients were less likely to present with obstructive coronary artery disease. Instead, the oxygen deprivation and subsequent damage to the heart is more likely to occur when small blood vessels, not major arteries, become dysfunctional.

"That is the reason women are often misdiagnosed and suffer adverse events," said Dr. Bairey Merz. "Physicians have been looking for male pattern disease, when we need to start looking at female patterns." Likewise, more research is needed to develop appropriate treatments and reduce risk in women, she added.

According to Dr. Bairey Merz, the good news is that it is possible to measure damage to small blood vessels objectively. "The gold standard is reactivity testing, angiograms, and other physiologic measures, rather than anatomic study."

Dr. Bairey Merz will provide an overview of the latest data about these methods and how they can be applied to help clinicians understand gender differences in the pathophysiology of heart disease during her presentation.


'/>"/>
Contact: Donna Krupa
dkrupa@the-aps.org
301-634-7209
American Physiological Society
Source:Eurekalert

Related biology news :

1. Einstein College of Medicine given $6.7 million to study congenital heart defect genetics
2. WPI mathematics professor Dalin Tang elected a Fellow of the American Heart Association
3. SynCardias Total Artificial Heart Rescues LVAD Patient with Right Ventricular Failure
4. Kansas researchers find enriched infant formulas benefit brain and heart
5. New data from studies bolsters case for using aldosterone antagonists in heart failure
6. Protein found in heart may be target for colon cancer therapies
7. Poor growth, delayed puberty and heart problems plague kids with mild kidney disease
8. Groundbreaking research reveals clues to the formation of hearts, intestines and other key organs
9. UCLA study shows man-made fat may limit damage to heart attack victims
10. Sea squirt pacemaker gives new insight into evolution of the human heart
11. BUSM professor selected as American Heart Association Distinguished Scientist
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/6/2017)... , Jan. 5, 2017  SomaLogic announced today ... Life Alliance" established by iCarbonX, the ... build a "Global Digital Health Ecosystem that can ... combination of individual,s biological, behavioral and psychological data, ... between the companies, SomaLogic will provide proteomics data ...
(Date:1/4/2017)... 4, 2017  CES 2017 – Valencell , ... today announced the launch of two new versions ... highly-accurate biometric sensor modules that incorporate the best ... and expertise. The two new designs include Benchmark ... hearables, and Benchmark BW2.0, a 2-LED version of ...
(Date:12/22/2016)... December 22, 2016 SuperCom (NASDAQ: ... solutions for the e-Government, Public Safety, HealthCare, and Finance sectors announced ... has been selected to implement and deploy a community-based supportive services ... Northern California , further expanding its presence in the state. ... This new program, ...
Breaking Biology News(10 mins):
(Date:1/17/2017)... ... January 17, 2017 , ... Diagenode, a ... announced a collaboration with the Heidelberg University Hospital and the German Cancer Research ... following the company’s successful launch of its CATS (Capture and Amplification by ...
(Date:1/16/2017)... Amawalk, NY (PRWEB) , ... January 16, 2017 ... ... for New Jersey laws precedential publication its decision on the appeal filed by ... FDASmart’s lawsuit of breach of contract against DPCL and one of its Dishman ...
(Date:1/16/2017)... , Jan. 16, 2017  Eurofins Genomics today ... will allow more customers to receive their primers in ... or compromise in quality found with other providers. Express ... United States at no additional fee. ... routine genetic studies, including DNA sequencing, genotyping, site-directed mutagenesis, ...
(Date:1/13/2017)... Research and Markets has announced the addition ... Forecast to 2021" report to their offering. ... The biosimilars market is expected ... in 2016, at a CAGR of 26.3%. The ... type, and application. Factors such as rising incidence of various diseases, ...
Breaking Biology Technology: