Navigation Links
Women with BRCA mutations can take hormone-replacement therapy safely after ovary removal
Date:6/1/2011

(CHICAGO) Women with the BRCA1 or BRCA2 gene mutations, which are linked to a very high risk of breast and ovarian cancer, can safely take hormone-replacement therapy (HRT) to mitigate menopausal symptoms after surgical removal of their ovaries, according to new research from the Perelman School of Medicine at the University of Pennsylvania which will be presented Monday, June 6 during the American Society for Clinical Oncology's annual meeting (Abstract #1501). Results of the prospective study indicated that women with BRCA mutations who had their ovaries removed and took short-term HRT had a decrease in the risk of developing breast cancer.

Research has shown that in women who carry the BRCA mutations, the single most powerful risk-reduction strategy is to have their ovaries surgically removed by their mid-30s or early 40s. The decrease in cancer risk from ovary removal comes at the cost of early menopause and menopausal symptoms including hot flashes, mood swings, sleep disturbances and vaginal dryness quality-of-life issues that may cause some women to delay or avoid the procedure.

"Women with BRCA1/2 mutations should have their ovaries removed following child-bearing because this is the single best intervention to improve survival," says lead author Susan M. Domchek, MD, an associate professor in the division of Hematology-Oncology and director of the Cancer Risk Evaluation Program at Penn's Abramson Cancer Center. "It is unfortunate to have women choose not to have this surgery because they are worried about menopausal symptoms and are told they can't take HRT. Our data say that is not the case these drugs do not increase their risk of breast cancer."

Senior author Timothy R. Rebbeck, PhD, associate director of population science at the Abramson Cancer Center, notes that BRCA carriers may worry based on other studies conducted in the general population showing a link between HRT and elevated cancer risk that taking HRT may
'/>"/>

Contact: Holly Auer
holly.auer@uphs.upenn.edu
215-200-2313
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Women do not recover their muscle strength as fast as men
2. Brown University and Women & Infants Hospital expand national childrens study to Bristol County
3. Vitamin K does not stem BMD decline in postmenopausal women with osteopenia
4. Study: Elderly Women can increase strength but still risk falls
5. Pregnant women consuming flaxseed oil have high risk of premature birth
6. 17th Annual Congress on Womens Health convenes
7. Pregnant women with asthma can be more confident about some medicines
8. Men are red, women are green, Brown researcher finds
9. Statin warning for pregnant women
10. Long-term use of diabetes drugs by women significantly increases risk of fractures
11. Women double fruit, veggie intake with switch to Mediterranean diet plan
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... OXFORD, Conn. , May 5, 2015, NXT-ID, ... biometric authentication company focused on the growing mobile commerce market, ... the Company,s Chief Technology Officer, is presenting  at CARTES SECURE ... May 5-7, 2015. The three-day conference ... session David is speaking in is themed Global Fraud: ...
(Date:4/27/2015)... Fla. , Apr. 27, 2015 Profile ... access control and security systems is pleased to announce ... company as a consultant and member of its scientific ... is widely known as a thought leader in technology-enhanced ... Learning Technology Group, and has published studies and books ...
(Date:4/20/2015)... DUBAI , April 20, 2015 ... soars   Glenbeigh Records Management (GRM), ... contract with Dubai Islamic Bank. Having built up an impressive ... is now a leading player within the records management sector ... company expects to double is GCC staffbase and employ a ...
Breaking Biology News(10 mins):NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3
... Science Research Conference focuses on signaling pathway feedback loops, ... rewiring. A growing appreciation has emerged that though ... been identified in the last three decades an in ... inputs needs to be elucidated. The conference ...
... Every picture tells a story, but the story ... change could be incomplete, according to new research. ... have shown that the peak in forest greenness as ... direct measures of peak chlorophyll content in leaves, which ...
... the winners of its annual CPOW Travel Awards to ... Moscone Center in San Francisco, February 15-19, 2014. CPOW, ... has initiated these travel fellowships to increase the number ... Meeting. The recipients of this competitive award must ...
Cached Biology News:Image or reality? Leaf research needs photos and lab analysis 2Image or reality? Leaf research needs photos and lab analysis 3Biophysical Society announces winners of 2014 CPOW Travel Awards 2
(Date:6/3/2015)... 03, 2015 CIRTEC Medical Systems ... services for complex Class III implantable devices and minimally ... UT Dallas-led initiative aimed at identifying potentially marketable biomedical ... institutions and moving them more efficiently from the laboratory ... history of working with the world's largest OEMs and ...
(Date:6/3/2015)... and CHICAGO , June 3, 2015 ... "the Company"; LSE: CIR), a specialty biopharmaceutical company focused ... relating to the Company,s novel immunotherapy candidates targeting house ... at the 2015 European Academy of Allergy and Clinical ... Spain on 6-10 June. Sunday, ...
(Date:6/3/2015)... Milan, Tennessee (PRWEB) June 03, 2015 ... facility in Milan, Tennessee to support the RCBC Waste ... Energy is fourth generation in the family business, ... since 1908. His family added recycling to their ... waste and recycling services to the Fortune 500 companies ...
(Date:6/3/2015)... Roanoke, Virginia (PRWEB) June 03, 2015 ... officially changed its name to PogoTec™, Inc. ( ... of its electronic wearable device products and technologies it ... the creation of three business divisions, PogoTec™ will provide ... wearable devices as follows: , , ...
Breaking Biology Technology:CIRTEC Medical Systems to support new UT Dallas-led Initiative to deliver biomedical technologies from laboratory bench to bedside more efficiently 2Circassia to Present at EAACI Annual Meeting, Barcelona, Spain, 6-10 June 2015 2Circassia to Present at EAACI Annual Meeting, Barcelona, Spain, 6-10 June 2015 3Photo-Eyewear™ Changes Name to PogoTec™ and Announces Three Divisions 2Photo-Eyewear™ Changes Name to PogoTec™ and Announces Three Divisions 3
... Pharsight,Corporation (Nasdaq: PHST ), a leading provider ... clinical drug,development announced today that it will be ... Conference on February 28, 2008 at the,Walt Disney ... and CEO, and William Frederick, Senior Vice President ...
... QED International Associates, Inc.,administrator for the HealthShares(TM) Indexes, ... Exchange-Traded Funds, today announced,that effective at the opening ... Co. (NYSE: KV.A) will replace Bradley Pharmaceuticals, Inc.,(NYSE: ... Wound Care Index.,Bradley is being acquired by Nycomed ...
... Biopure Corporation,(Nasdaq: BPUR ) today announced its financial ... For the quarter, the company reported a net,loss of ... a net loss,of $6.9 million, or $0.53 per common ... shares outstanding on January 31, 2008 and 2007 were,34,971,087 ...
Cached Biology Technology:Pharsight to Present at Jesup and Lamont 2008 Emerging Growth Stock Conference 2Biopure Announces 2008 First Quarter Financial Results 2Biopure Announces 2008 First Quarter Financial Results 3Biopure Announces 2008 First Quarter Financial Results 4Biopure Announces 2008 First Quarter Financial Results 5Biopure Announces 2008 First Quarter Financial Results 6Biopure Announces 2008 First Quarter Financial Results 7