Navigation Links
Women often opt to surgically remove their breasts, ovaries to reduce cancer risk
Date:8/5/2009

PHILADELPHIA Many women at high risk for breast or ovarian cancer are choosing to undergo surgery as a precautionary measure to decrease their cancer risk, according to a report in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

"Women have their breasts or ovaries removed based on their risk. It does not always happen immediately after counseling or a genetic test result and can take more than seven years for patients to decide to go forward with surgery," said lead researcher D. Gareth Evans, M.D. Evans is a consultant in clinical genetics at the Genesis Prevention Center, University Hospital of South Manchester NHS Trust and a professor at the University of Manchester, United Kingdom.

Evans and colleagues assessed the increase in risk-reduction surgery among women with breast cancer and evaluated the impact of cancer risk, timing and age.

Rate of increase was measured among 211 women with known unaffected BRCA1 or BRCA2 mutation carriers. BRCA1 and BRCA2 are hereditary gene mutations that indicate an increased risk for developing breast cancer. Additionally, more than 3,500 women at greater than 25 percent lifetime risk of breast cancer without mutations also had a documented increase in risk-reduction surgery.

Women who had a biopsy after undergoing risk evaluation were twice as likely to choose a risk-reducing mastectomy. Forty percent of the women who were mutation carriers underwent bilateral risk-reducing mastectomy; 45 percent had bilateral risk-reducing salpingo-oophorectomy (surgical removal of ovaries). These surgeries are widely used by carriers of BRCA1 and BRCA2 gene mutations to reduce the risk for breast and ovarian cancer.

Evaluated by gene type, bilateral risk-reducing salpingo-oophorectomy was more common in women who were BRCA1 gene carriers 52 percent had the surgery compared with 28 percent of the women who were BRCA2 gene car
'/>"/>

Contact: Tara Yates
tara.yates@aacr.org
267-646-0558
American Association for Cancer Research
Source:Eurekalert

1

GOOD

Page: 1 2 3

Related biology news :

1. Health benefits of physical activity more pronounced in women
2. UTMB study identifies women at risk of gaining excessive weight with injectable birth control
3. Study explains potential failure of oral contraceptives with obese women
4. Fruit and vegetable intake in pregnant women reduces risk of upper respiratory tract infection
5. Two dietary oils, two sets of benefits for older women with diabetes
6. Women with endometriosis need special care during pregnancy to avoid risk of premature birth
7. New MRI technique could mean fewer breast biopsies in high-risk women
8. New, less invasive genetic test greatly improves pregnancy rates in older women with poor prognosis
9. Debate on admin. of magnesium sulfate to pregnant women to prevent cerebral palsy in pre-term infants
10. Following the dietary guidelines may slow heart disease in women
11. Single women gaze longer

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2009)... 24, 2009) -- The Wildlife Conservation Society (W...st remaining population of Siberian tigers has lik...of poaching and habitat loss. , WCS ... of what needs to be done to protect remaining pop... The report was released by the Siberian Tiger ...
(Date:11/24/2009)...atter of debate. A high-profile study a few years ...heir carbon from trees and leaves, evidence for a ...c ecosystems. , But new research from the Univer...true. Algae provide a much richer diet for fish an...hed this week in the Proceedings of the National ...
(Date:11/24/2009)...nish . , The presence of increased body fat,...ances in the blood, hinders the loss and maintenan...of the University of Navarra conducted by Estbaliz...rmacy. , The project, entitled "A nutrigenetic a...f body weight and inflammation," examines how the ...
Breaking Biology News(10 mins):Report shows dramatic decline in Siberian tigers 2Fish food fight: Fish don't eat trees after all, says new study 2Fish food fight: Fish don't eat trees after all, says new study 3It can be predicted the reaction obese patients will have to a diet 2Cord Blood America Retires Note in Continuing Effort to Reduce Debt 58743 1Cord Blood America Retires Note in Continuing Effort to Reduce Debt 58743 2BIA Publishes White Paper 3A ISO 9000 Role in Document Review Emphasizes Quality Equals Defensibility 5183 1BIA Publishes White Paper 3A ISO 9000 Role in Document Review Emphasizes Quality Equals Defensibility 5183 2BIA Publishes White Paper 3A ISO 9000 Role in Document Review Emphasizes Quality Equals Defensibility 5183 3GetReel Health and CheckOrphan Partner to Help Rare Orphan and Neglected Diseases 14331 1GetReel Health and CheckOrphan Partner to Help Rare Orphan and Neglected Diseases 14331 2GetReel Health and CheckOrphan Partner to Help Rare Orphan and Neglected Diseases 14331 3GetReel Health and CheckOrphan Partner to Help Rare Orphan and Neglected Diseases 14331 4
...ce sheet , Studies have indicated that the Green...easing average summer air temperatures in southern... the ice sheet,s mass from 1958 through 2008, Rign...ch is obtained from remote sensing techniques; and...el of melting ice and snowpack accumulation. The a...
...evier, a leading publisher of scientific, technica...nnounced today that it will publish NJAS - Wageni...er.com/locate/njas ) on behalf of Royal Netherland...g in 2009 with Volume 57, issue 1. , NJAS - Wage...1952, is the quarterly journal of the Royal Nether...
...rthern migration of invasive marine is one of many...pening day presentations at the First World Confer... las Ciencias, in Valencia. , Investigators repor...d at 50 km per decade, a distance far greater than... difference may be due to the rapid dispersion of ...
Other Biology News:AGU journal highlights: Nov. 11, 2008 2AGU journal highlights: Nov. 11, 2008 3AGU journal highlights: Nov. 11, 2008 4AGU journal highlights: Nov. 11, 2008 5AGU journal highlights: Nov. 11, 2008 6AGU journal highlights: Nov. 11, 2008 7AGU journal highlights: Nov. 11, 2008 8AGU journal highlights: Nov. 11, 2008 9AGU journal highlights: Nov. 11, 2008 10Marine invasive species advance 50 km per decade, World Conference on Marine Biodiversity told 2Marine invasive species advance 50 km per decade, World Conference on Marine Biodiversity told 3Marine invasive species advance 50 km per decade, World Conference on Marine Biodiversity told 4
(Date:11/24/2009)... Health care employment grew by 29,000 jobs... show consistent growth during the U.S. recession....n trouble, and health systems are coming closer to... of just administrators. , ...ent continued growing in October despite the shedd...
(Date:11/24/2009)....24/PRNewswire-Asia/--ShanghaiBiolaxyannouncedthe,...provedthe,investigationalnewdrugapplication(IND)fo...nformulationtotreatdiabetes.ThisIND,approvalallows..., Diabetesisadisordercharacteristicofhighbloodglu...ftenresultinseveremicro-and,macro-vasculardiseases...
(Date:11/24/2009)...TL , TORONTO,Nov.24/PRNewswire-FirstCall/-Ham...nc.,aleadingproviderofadvancedlasersystemsandinstr...ets,todayreportedoperationalandfinancialresultsfor...ghlights,-Revenuewas$1.46millioncomparedwith$1.43...mparedwith66.1percentinQ3,2008,-Netlossreducedto$1...
(Date:11/24/2009)...November24/PRNewswire/--HealthRoboticstodayannounc...upofselected,investors.ThisrecentlyformedToronto-b...anada,Inc.andwillmarket,install,andsupport,HealthR...e,revolutionaryproductofferingsi.v.STATION(TM),i.v...alsoprovideassistanceonan"asneeded,basis"toitsstra...
Breaking Biology Technology:The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close 2The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close 3The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close 4Biolaxy Secures IND Approval for Oral Insulin 2Hamilton Thorne announces third quarter results 2Hamilton Thorne announces third quarter results 3Hamilton Thorne announces third quarter results 4Hamilton Thorne announces third quarter results 5Hamilton Thorne announces third quarter results 6Hamilton Thorne announces third quarter results 7Health Robotics Continues its Global Expansion With December 09 ASHP's Launch of Joint Venture in Canada 2
...ARY, Dec. 21 /PRNewswire-FirstCall/ - Oncolytics B...has completed patient enrolment in,its Phase Ia/Ib...al,delivery of REOLYSIN(R) in combination with rad...total of 23 patients received a range of two to,si... dosages up to a,maximum of 1x10(10) TCID(50) with...
...LOTTESVILLE, Va., Dec. 21 Diffusion Pharmaceutica...commercializing,first-in-class drugs utilizing a n...usion, today announced that one of its key advisor...co-inventor of the underlying,technology of Amgen,..., a,erythropoiesis stimulating agent (US Patent No...
...CETON, N.J., Dec. 21 Otsuka Pharmaceutical,Develo...at the U.S. Food,and Drug Administration has accep... investigational oral once-daily medication tolvap...t, for two indications: treatment of,adults with w...ia.(1) These,indications are based on data from th...
Other Biology Technology:Oncolytics Biotech Inc. Completes Patient Enrolment in U.K. Phase Ia/Ib Combination REOLYSIN(R)/Radiation Clinical Trial 2Co-Inventor of Amgen's Aranesp(R) Technology Directs Worldwide Patent Strategy for Diffusion Pharmaceuticals' First-in-Class Oxygen Enhancing Therapeutics 2New Drug Application for Tolvaptan, Otsuka's Investigational Novel Oral Treatment for Worsening Heart Failure and Hyponatremia, Accepted by the U.S. Food and Drug Administration 2New Drug Application for Tolvaptan, Otsuka's Investigational Novel Oral Treatment for Worsening Heart Failure and Hyponatremia, Accepted by the U.S. Food and Drug Administration 3
Rabbit Anti-Human Thymosin beta4 Polyclonal Antibody, Unconjugated from Calbiochem
...proven, validated Sanger dideoxy DNA sequencing, t...ughput capillary sequencing instrumentation. The p... both directions. The use of DNA sequencing also p...irming the location of the polymorphic site. Rap...
Mini ReadySub-Cell GT Cell and PowerPac Basic Power Supply from Bio-Rad
...220-240 V, is used for nucleic acid separation usi...em includes the modular Sequi-Gen GT electrophores...ids with single base-pair resolution and includes ...bonded inner glass plate, outer glass plate, and c...
Biology Products: