Navigation Links
Women more depressed and men more impulsive with reduced serotonin functioning
Date:9/17/2007

Philadelphia, PA, September 17, 2007 Women and men appear to respond differently to the same biochemical manipulation. Major depressive disorder (MDD) is one of the most common mental disorders, and it is also one of the most studied. It is already known that reduced serotonin transmission contributes to the pathophysiology, or functional changes, associated with MDD and most of todays most popular antidepressants block the serotonin uptake site, also known as the transporter, in the brain. It is also known that people with MDD are frequently found to have impaired impulse control. A new study being published in the September 15th issue of Biological Psychiatry now reports on important sex and genetic differences in the way that men and women react to reductions in serotonin function, specifically in terms of their mood and impulsivity.

Using a technique in healthy participants called acute tryptophan depletion, which decreases serotonin levels in the brain, Walderhaug and colleagues found that men became more impulsive, but did not experience any mood changes in response to the induced chemical changes. However, women in this study reported a worsening of their mood and they became more cautious, a response commonly associated with depression. The researchers also discovered that the mood lowering effect in women was influenced by variation in the promotor region of the serotonin transporter gene (5-HTTLPR).

One of the studys authors, Dr. Espen Walderhaug, explains, We were surprised to find such a clear sex difference, as men and women normally experience the same effect when the brain chemistry is changed Although we have the same serotonergic system in the brain, it is possible that men and women utilize serotonin differently.

These findings highlight the complexity of studying and treating these disorders, as the interactive effects of gender and genetic coding impacted the outcomes in the men and women when their serotonergic functions were disrupted. Dr. Walderhaug comments that their studys findings might be relevant in understanding why women show a higher prevalence of mood and anxiety disorders compared to men, while men show a higher prevalence of alcoholism, ADHD and impulse control disorders. John H. Krystal, M.D., Editor of Biological Psychiatry and affiliated with both Yale University School of Medicine and the VA Connecticut Healthcare System, adds that the response patterns that have emerged in these findings are the beginnings of an understanding for these sex-related effects. Ultimately, it is hoped that these findings further advance the ability to quickly and more accurately treat patients.


'/>"/>

Contact: Jayne M. Dawkins
ja.dawkins@elsevier.com
215-239-3674
Elsevier
Source:Eurekalert

Related biology news :

1. Male circumcision reduces risk of HIV transmission from women to men
2. Variation in womens X chromosomes may explain differences among individuals, between sexes
3. Of mice and mens (and womens) contraceptives
4. Survey reveals women and doctors arent talking about HPV
5. Men Estimate Mens Risks Of Common Disorders Higher Than Women Do, And Vice Versa
6. Pregnant women at higher risk for HIV, Uganda study finds
7. Higher risk for cervical cancer seen among women infected with multiple HPV types
8. Women cautioned against using herbal supplements
9. Screen all at risk for HIV, plus pregnant women
10. Women feel more pain than men, research shows
11. Agreement will speed research on microbicides for women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/11/2017)... 2017  Michael Johnson, co-founder of Visikol Inc. a company originally ... been named to the elite "Forbes 30 Under 30" list in ... people in 20 fields nationwide to be recognized as a leader ... were selected. ... is currently a PhD candidate at Rutgers University. ...
(Date:1/6/2017)... 2017  SomaLogic announced today that it has ... by iCarbonX, the China -based ... Digital Health Ecosystem that can define each person,s ... biological, behavioral and psychological data, the Internet and ... SomaLogic will provide proteomics data and applications expertise ...
(Date:1/4/2017)... the thousands of attendees at this year,s International Consumer Electronics Show (CES), ... measurement devices and services, will be featuring its new line of ULTRA ... special CES Exhibit Suite , the new upper arm and wrist ... WellnessConnected product platform.  Continue Reading ... ...
Breaking Biology News(10 mins):
(Date:1/20/2017)... ... January 20, 2017 , ... ... the next evolution in spinal fusion, the MISquito Percutaneous Pedicle Screw System ... competition, SpineFrontier is focused on technique driven product solutions that provide maximum ...
(Date:1/19/2017)... India , Jan. 19, 2017  Market Research Future has ... Global Market for Liquid Biopsy is growing rapidly and expected to ... Market Highlights ... The Global Liquid Biopsy Market has been assessed as a ... growth figures and boom in the coming future. There has been ...
(Date:1/19/2017)... , Jan. 19, 2017 /PRNewswire -- WuXi ... device open-access capability and technology platform, today announced ... leading biology focused preclinical drug discovery contract research ... will become a wholly-owned subsidiary of WuXi, and ... competences and providing greater services. The acquisition will ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... development (R&D), today announced the launch of Data Science Services , ... rapidly evolving field of precision medicine. , Data Science Services allows ...
Breaking Biology Technology: