Navigation Links
Women more depressed and men more impulsive with reduced serotonin functioning
Date:9/17/2007

Philadelphia, PA, September 17, 2007 Women and men appear to respond differently to the same biochemical manipulation. Major depressive disorder (MDD) is one of the most common mental disorders, and it is also one of the most studied. It is already known that reduced serotonin transmission contributes to the pathophysiology, or functional changes, associated with MDD and most of todays most popular antidepressants block the serotonin uptake site, also known as the transporter, in the brain. It is also known that people with MDD are frequently found to have impaired impulse control. A new study being published in the September 15th issue of Biological Psychiatry now reports on important sex and genetic differences in the way that men and women react to reductions in serotonin function, specifically in terms of their mood and impulsivity.

Using a technique in healthy participants called acute tryptophan depletion, which decreases serotonin levels in the brain, Walderhaug and colleagues found that men became more impulsive, but did not experience any mood changes in response to the induced chemical changes. However, women in this study reported a worsening of their mood and they became more cautious, a response commonly associated with depression. The researchers also discovered that the mood lowering effect in women was influenced by variation in the promotor region of the serotonin transporter gene (5-HTTLPR).

One of the studys authors, Dr. Espen Walderhaug, explains, We were surprised to find such a clear sex difference, as men and women normally experience the same effect when the brain chemistry is changed Although we have the same serotonergic system in the brain, it is possible that men and women utilize serotonin differently.

These findings highlight the complexity of studying and treating these disorders, as the interactive effects of gender and genetic coding impacted the outcomes in the men and women when their serotonergic functions were disrupted. Dr. Walderhaug comments that their studys findings might be relevant in understanding why women show a higher prevalence of mood and anxiety disorders compared to men, while men show a higher prevalence of alcoholism, ADHD and impulse control disorders. John H. Krystal, M.D., Editor of Biological Psychiatry and affiliated with both Yale University School of Medicine and the VA Connecticut Healthcare System, adds that the response patterns that have emerged in these findings are the beginnings of an understanding for these sex-related effects. Ultimately, it is hoped that these findings further advance the ability to quickly and more accurately treat patients.


'/>"/>

Contact: Jayne M. Dawkins
ja.dawkins@elsevier.com
215-239-3674
Elsevier
Source:Eurekalert

Related biology news :

1. Male circumcision reduces risk of HIV transmission from women to men
2. Variation in womens X chromosomes may explain differences among individuals, between sexes
3. Of mice and mens (and womens) contraceptives
4. Survey reveals women and doctors arent talking about HPV
5. Men Estimate Mens Risks Of Common Disorders Higher Than Women Do, And Vice Versa
6. Pregnant women at higher risk for HIV, Uganda study finds
7. Higher risk for cervical cancer seen among women infected with multiple HPV types
8. Women cautioned against using herbal supplements
9. Screen all at risk for HIV, plus pregnant women
10. Women feel more pain than men, research shows
11. Agreement will speed research on microbicides for women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2017)... 18, 2017  Socionext Inc., a global expert in SoC-based imaging ... server, the M820, which features the company,s hybrid codec technology. A ... Tera Probe, Inc., will be showcased during the upcoming Medtec Japan ... at the Las Vegas Convention Center April ... Click here for ...
(Date:4/13/2017)... April 13, 2017 UBM,s Advanced Design and ... will feature emerging and evolving technology through its 3D ... will run alongside the expo portion of the event ... and demonstrations focused on trending topics within 3D printing ... and manufacturing event will take place June 13-15, 2017 at ...
(Date:4/11/2017)... PALM BEACH GARDENS, Fla. , April 11, ... biometric identity management and secure authentication solutions, today ... million contract by Intelligence Advanced Research Projects Activity ... technologies for IARPA,s Thor program. "Innovation ... the onset and IARPA,s Thor program will allow ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... prospective clinical study that demonstrates the accuracy of the FebriDx® test, a ... significant acute bacterial and viral respiratory tract infections by testing the body’s ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
(Date:10/11/2017)... , ... October 11, 2017 , ... Personal eye wash is a basic first aid ... at a time. So which eye do you rinse first if a dangerous substance enters ... Plum Duo Eye Wash with its unique dual eye piece. , “Whether its dirt ...
(Date:10/11/2017)... INDIANAPOLIS , Oct. 11, 2017  VMS BioMarketing, a ... of a nationwide oncology Clinical Nurse Educator (CNE) network, which ... growing need for communication among health care professionals to enhance ... physicians, nurses, office staff, and other health care professionals to ... for breast cancer. ...
Breaking Biology Technology: