Navigation Links
With new method, CSHL team is able to infer how tumors evolve and spread
Date:3/13/2011

Cold Spring Harbor, NY -- A new method of analyzing cancerous tumors developed by scientists at Cold Spring Harbor Laboratory (CSHL) suggests that tumors may not evolve gradually, but rather in punctuated or staccato-like bursts. It is a finding that has already shed new light on the process of tumor growth and metastasis, and may help in the development of new methods to clinically evaluate tumors.

The new analytic method, devised by CSHL Professor Michael Wigler and colleagues, features a process called single cell sequencing (SNS), which enables accurate quantification of genomic copy number within a single cell nucleus. Genomic copy number refers to the amount of DNA in the nucleus. In cancer, portions of the genome are amplified or deleted, giving rise to extra or missing copies of key genes and interfering with mechanisms that normally control cell growth.

In a study published today in the journal Nature, "we demonstrated that we can obtain accurate and high-resolution copy number profiles by sequencing a single cell from a cancerous tumor," says Wigler, "and that by examining multiple cells from the same cancer, we can make inferences about how the cancer evolved and spread." The CSHL team also includes Professor W. Richard McCombie, Assistant Professor Alex Krasnitz and Research Professor James Hicks. Nicholas Navin, the paper's first author, was a graduate student while pursuing the research at CSHL and is now Assistant Professor at MD Anderson Cancer Center in Texas.

The importance of cancer's heterogeneity

It has been very difficult for scientists to translate their growing ability to classify tumors at the molecular level into methods and tests that can be used in the clinic to analyze tumors in actual patients. But basic research has firmly established that cancer is highly heterogeneous, meaning that cancers of a certain type, for instance cancers of the breast or lung or colon, can be subdiv
'/>"/>

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. Why chemotherapy causes more infertility in women than in men
2. Mildew-resistant and infertile
3. Reproductive health: Checkerboard of infertility treatment in Europe
4. Swimming upstream: Molecular approaches to better understand male infertility
5. U of I study: Lack of omega-3 fatty acid linked to male infertility
6. Researchers identify gene with possible link to infertility in mice
7. ESHREs first workshop on male infertility in Thessaloniki
8. Small RNAs can play critical roles in male infertility/contraception
9. Fireflies and jellyfish help illuminate quest for cause of infertility
10. Miscarriage and infertility treatment increase pre-eclampsia risk
11. Proteins in sperm unlock understanding of male infertility says new study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... learned a great deal about complex social behavior by ... something to teach too. , With their unusually large ... parrots live in a complex social environment---not merely in ... or ants, but in a dynamic setting of alliances ... intelligent mammals: dolphins, whales, primates, and social carnivores, like ...
(Date:9/16/2014)... Environmental Health at the Mailman School of Public Health ... asthma and prenatal exposure to two phthalates used in ... in the journal Environmental Health Perspectives . ... higher levels of the chemicals, butylbenzyl phthalate (BBzP) and ... percent increase in risk of developing asthma between age ...
(Date:9/16/2014)... CLEVELAND, Ohio (September 17, 2014)The North American Menopause ... for the comprehensive care of midlife womenon everything ... feature, "The North American Menopause Society Recommendations for ... today in the Society,s journal Menopause . ... recommendations for the care of midlife women freely ...
Breaking Biology News(10 mins):Being social: Learning from the behavior of birds 2Phthalates heighten risk for childhood asthma 2Phthalates heighten risk for childhood asthma 3
... A team of scientists from the University Hospitals of ... bowel diseases have low bone mass and poor bone architecture ... at increased risk of fracture. Inflammatory bowel disease ... inflammation of the bowel. Two of the most common disorders ...
... new study presented today at the World Congress on ... a commonly used injectible contraceptive, is associated with higher ... in combination with estrogens. Depot medroxyprogesterone acetate ... birth control drug which is injected every 3 months. ...
... muscle tissue experiences trauma or disease, such as ... as "satellite cells" respond to repair and regenerate ... neuromuscular diseases, such as muscular dystrophy, which affect ... researchers have used time-lapse photography to document satellite ...
Cached Biology News:Caught on tape: Muscle stem cells captured on video by MU researcher 2
(Date:9/17/2014)... FORT LAUDERDALE, Fla. , Sept. 17, 2014 ... signed an agreement to form a Special Purpose Vehicle in ... based Jatropha centric agro energy company. The SPV shall ... U.S. registered entity with AFAI as majority shareholder. The SPV ... Africa , particularly Ethiopia . ...
(Date:9/17/2014)... RXi Pharmaceuticals Corporation (NASDAQ: ... developing and commercializing innovative therapies addressing major unmet ... has been granted a patent by the United ... delivery system for delivering its "original" RNAi compounds ... treatment of diseases with an inflammatory component. Potential ...
(Date:9/17/2014)... CA (PRWEB) September 17, 2014 Escape Alert, ... for pets which will alert owners if their pet has ... GPS from an implanted microchip in the pet’s body. This ... microchips for pets have been around for many years, they ... are not able to track a pet’s location or alert the ...
(Date:9/17/2014)... (PRWEB) September 17, 2014 The ... committed to lowering the barriers to innovation in ... the appointment of Carmen Nitsche as Executive Director ... to expand its global reach. , Carmen joins ... Vice President, Corporate Development. At Accelrys, she managed ...
Breaking Biology Technology:AFAI Signs Joint Venture Agreement With Jatro Greentech Inc. 2AFAI Signs Joint Venture Agreement With Jatro Greentech Inc. 3RXi Pharmaceuticals Strengthens Intellectual Property Portfolio 2RXi Pharmaceuticals Strengthens Intellectual Property Portfolio 3RXi Pharmaceuticals Strengthens Intellectual Property Portfolio 4Implantable Microchip for Pets with GPS Tracking - Patent Filed by Escape Alert, LLC. 2Implantable Microchip for Pets with GPS Tracking - Patent Filed by Escape Alert, LLC. 3Pistoia Alliance Expands Business Development with Appointment of Carmen Nitsche 2
... photonics and renewable energy will be the focus of ... to 14, 2009 at McMaster University in Hamilton, Ontario, ... in conjunction with the event. , The 4th Nano ... the 14th Canadian Semiconductor Technology Conference (CSTC2009) will bring ...
... UC Riverside have made an accidental discovery in ... information in computers can be transported or stored. ... electrons possess that makes them behave like tiny ... of spin-based semiconductor technology such as ultrahigh-speed computers. ...
... programs give sponsors easy-to-use tools to store, mine and ... transfer knowledge base to ensure enrollment success, NEWTON, ... technology leader, announced the release of a new,product, "Center ... in-house recruitment capabilities for clinical,trial sponsors. The goal is ...
Cached Biology Technology:Joint nanotechnology forum to focus on electronics, photonics, renewable energy 2Discovery by UC Riverside physicists could enable development of faster computers 2Discovery by UC Riverside physicists could enable development of faster computers 3TCN e-Systems Offers Trial Sponsors Solutions for Creating In-House Center of Excellence in Patient Recruitment 2TCN e-Systems Offers Trial Sponsors Solutions for Creating In-House Center of Excellence in Patient Recruitment 3TCN e-Systems Offers Trial Sponsors Solutions for Creating In-House Center of Excellence in Patient Recruitment 4
Anti-ADAM-12 (Meltrin Alpha); amino terminal region; rabbit host...
Mouse monoclonal [3G8] to MDMA ( Abpromise for all tested applications)....
Fluorescein isothiocyanate (FITC) mouse anti-human IFN-alpha2 25 tests...
Rabbit Anti-melatonin (different linkage) Polyclonal Antibody...
Biology Products: