Navigation Links
With HMGB1's help, cells dine in
Date:9/6/2010

Like some people, cells eat when they are under pressurebut they consume parts of themselves. A multi-function protein helps control this form of cannibalism, according to a study in the September 6 issue of the Journal of Cell Biology (www.jcb.org).

Cells often respond to hunger or stress by digesting some of their contents. The process, known as autophagy, helps free nutrients and clean up cytoplasmic trash such as worn-out organelles and misshapen proteins. A team led by researchers at the University of Pittsburgh Cancer Institute discovered a link between this form of cellular recycling and the protein HMGB1. The team showed HMGB1 to be a critical pro-autophagic protein that enhances cell survival and limits programmed cell death.

The findings suggests that blocking HMGB1 could benefit cancer patients, since tumor cells often rev up autophagy to withstand chemotherapy, immunotherapy, and radiation treatment.


'/>"/>

Contact: Rita Sullivan
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert  

Page: 1

Related biology news :

1. Researchers identify how bone-marrow stem cells hold their breath in low-oxygen environments
2. Co-conspirator cells could hold key to melanoma prediction, prevention
3. Microfluidic device allows collection, analysis of hard-to-handle immune cells
4. Fat serves as cells built-in pH sensor: UBC research
5. Macrophages: The defense cells that help throughout the body
6. MIT researchers develop a better way to grow stem cells
7. Researchers discover how the storehouses of plant cells are formed
8. Potential HIV drug keeps virus out of cells
9. Study shows genes role in developing and maintaining cells key for a lifetime of memories
10. Scientists successfully use human induced pluripotent stem cells to treat Parkinsons in rodents
11. Drugs encased in nanoparticles travel to tumors on the surface of immune-system cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
With HMGB1's help, cells dine in
(Date:6/16/2016)... , June 16, 2016 ... is expected to reach USD 1.83 billion by ... View Research, Inc. Technological proliferation and increasing demand ... are expected to drive the market growth. ... The development of advanced multimodal techniques ...
(Date:6/9/2016)... 2016 Paris Police Prefecture ... security solution to ensure the safety of people and operations ... the major tournament Teleste, an international technology group ... announced today that its video security solution will be utilised ... up public safety across the country. The system roll-out is ...
(Date:6/2/2016)... LONDON , June 2, 2016 ... has awarded the 44 million US Dollar project, ... Security Embossed Vehicle Plates including Personalization, Enrolment, and IT Infrastructure ... world leader in the production and implementation of Identity Management ... in January, however Decatur was selected ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... NC (PRWEB) , ... June 23, 2016 , ... In ... University Hospital in Denmark detail how a patient who developed lymphedema after being treated ... tissue. The results could change the paradigm for dealing with this debilitating, frequent side ...
(Date:6/23/2016)... 2016  Blueprint Bio, a company dedicated to identifying, ... community, has closed its Series A funding round, according ... "We have received a commitment from Forentis Fund ... to meet our current goals," stated Matthew Nunez ... to complete validation on the current projects in our ...
(Date:6/23/2016)... On Wednesday, June 22, 2016, the NASDAQ Composite ... Jones Industrial Average edged 0.27% lower to finish at 17,780.83; ... has initiated coverage on the following equities: Infinity Pharmaceuticals Inc. ... NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ARLZ ), ... more about these stocks by accessing their free trade alerts ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... and technical consulting, provides a free webinar on Performing Quality Investigations: ... 2016 at 12pm CT at no charge. , Incomplete investigations are still a ...
Breaking Biology Technology: