Navigation Links
With HMGB1's help, cells dine in
Date:9/6/2010

Like some people, cells eat when they are under pressurebut they consume parts of themselves. A multi-function protein helps control this form of cannibalism, according to a study in the September 6 issue of the Journal of Cell Biology (www.jcb.org).

Cells often respond to hunger or stress by digesting some of their contents. The process, known as autophagy, helps free nutrients and clean up cytoplasmic trash such as worn-out organelles and misshapen proteins. A team led by researchers at the University of Pittsburgh Cancer Institute discovered a link between this form of cellular recycling and the protein HMGB1. The team showed HMGB1 to be a critical pro-autophagic protein that enhances cell survival and limits programmed cell death.

The findings suggests that blocking HMGB1 could benefit cancer patients, since tumor cells often rev up autophagy to withstand chemotherapy, immunotherapy, and radiation treatment.


'/>"/>

Contact: Rita Sullivan
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert  

Page: 1

Related biology news :

1. Researchers identify how bone-marrow stem cells hold their breath in low-oxygen environments
2. Co-conspirator cells could hold key to melanoma prediction, prevention
3. Microfluidic device allows collection, analysis of hard-to-handle immune cells
4. Fat serves as cells built-in pH sensor: UBC research
5. Macrophages: The defense cells that help throughout the body
6. MIT researchers develop a better way to grow stem cells
7. Researchers discover how the storehouses of plant cells are formed
8. Potential HIV drug keeps virus out of cells
9. Study shows genes role in developing and maintaining cells key for a lifetime of memories
10. Scientists successfully use human induced pluripotent stem cells to treat Parkinsons in rodents
11. Drugs encased in nanoparticles travel to tumors on the surface of immune-system cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
With HMGB1's help, cells dine in
(Date:11/21/2016)... VILNIUS, Lithuania , Nov. 21, 2016 /PRNewswire/ ... identification and object recognition technologies, today announced that ... for smart cards was submitted for the ... and successfully passed all the mandatory steps of ... III evaluation is a continuing test of fingerprint ...
(Date:11/17/2016)...  AIC announces that it has just released a new white paper authored by ... plus high speed data transfer storage solutions. Photo - http://photos.prnewswire.com/prnh/20161116/440463 ... ... ... Setting up a high performance computing or HPC system can ...
(Date:11/15/2016)... 15, 2016 Research and Markets has announced ... 2021" report to their offering. ... ... by 2021 from USD 6.21 Billion in 2016, growing at a ... of the bioinformatics market is driven by the growing demand for ...
Breaking Biology News(10 mins):
(Date:12/6/2016)... ... December 06, 2016 , ... ... company focused on discovery and development of precision treatments for neurodegenerative diseases, ... for Alzheimer’s disease (AD) inhibited the direct neurotoxic effect of prion-like forms ...
(Date:12/5/2016)... ... December 05, 2016 , ... This ... nanocrystals and cellulose nanofibrils. The composition claims are not limited to any ... directed to combination with polymers, carbon fibers, graphene, and other materials. A ...
(Date:12/5/2016)... ... , ... In anticipation of AxioMed’s exclusive cleanroom manufacturing facility ... Jake Lubinski will be traveling to Germany on December 6th. Mr. Lubinski will ... to discuss the benefits of a viscoelastic total disc replacement. , AxioMed received ...
(Date:12/5/2016)... - Resverlogix Corp. ("Resverlogix" or the "Company") (TSX:RVX) ... Monitoring Board (DSMB) for the Company,s Phase 3 ... has completed a second planned safety review and ... without any modifications. The DSMB reviewed available study ... concerns were identified. The DSMB will conduct additional ...
Breaking Biology Technology: