Navigation Links
With $1.6 million award, biochemist tackles diabetes
Date:1/9/2014

country to win an ADA Accelerator Award this year.

Wolfgang Peti"The easiest thing would be ... instead of injecting insulin, you'd just take a tablet. If you can control the insulin-signaling pathway with a drug, that would make your life much easier."Wolfgang Peti "The easiest thing would be ... instead of injecting insulin, you'd just take a tablet. If you can control the insulin-signaling pathway with a drug, that would make your life much easier."Peti's ambitious goal is to enable the development of medicines that improve on the status quo so greatly that insulin injections might no longer necessary.

"The easiest thing would be if you have type 2 diabetes instead of injecting insulin, you'd just take a tablet," he said. "If you can control the insulin-signaling pathway with a drug, that would make your life much easier."

Three targets

Many brilliant scientists share this goal, but so far the field has fallen short. Still, for all the well-worn dead ends, Peti still sees the insulin-signaling pathway as rife with potential new leads. He plans to look in novel ways and in novel places at the interactions of three main proteins in particular.

One target is the binding between insulin and the insulin receptor. That step activates the "TK" domain, or section, of the receptor, kicking off the cascade of protein signaling that leads to the metabolism of glucose. This may seem like an obvious place to start, but the complexity comes from trying to observe the movements of the TK domain and the specific timing that may be going awry in type 2 diabetes.

Peti and his colleagues have been able to model it all in E. coli bacteria, which will allow them to observe it precisely with NMR. That will allow Peti see how the TK domain reshapes and moves, how quickly and when. That could yield a clear understanding of whether a drug could block or slow a key movement that is happening too soon or too q
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Autism Speaks awards nearly $2.7 million for new research projects
2. After a 49-million-year hiatus, a cockroach reappears in North America
3. Physicians awarded $4 million to study effects of fertility treatments and obstetric care
4. Algae to crude oil: Million-year natural process takes minutes in the lab
5. UT Dallas awarded $1 million to improve prosthetics for soldiers
6. Pitt-led network gets $70 million over 7 years to develop, test HIV prevention products
7. A new species of horse, 4.4 million years old
8. EPA awards $1 million grant to NJITs Brownfield program
9. Army renews bio-inspired engineering and science research center at UC Santa Barbara with $48 million
10. Ancient fig wasp lived tens of millions of years before figs
11. TGen, Barrow and PCH receive $4 million grant to study genetic basis of brain injuries
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
With $1.6 million award, biochemist tackles diabetes
(Date:7/14/2014)... an inevitable consequence of aging? , Although it is ... aging, the risk of developing several common cancers decreases ... the apparent decrease with age in the risk of ... to this puzzle was presented in a recent paper ... Professor James P. Brody of the Department of Biomedical ...
(Date:7/14/2014)... make in the laboratory all of the different types of ... reality. , Writing today in the journal Nature Communications ... researcher Igor Slukvin reports the discovery of two genetic programs ... both red and the array of white cells that make ... identifies how nature itself makes blood products at the earliest ...
(Date:7/11/2014)... from the Wildlife Conservation Society shows that no-take ... valuable species such as lobster, conch, and fish ... nearby reef areas. , The reporttitled "Review of ... of research literature from no-take areas around the ... Dahlgren, a recognized expert in marine protected areas ...
Breaking Biology News(10 mins):Wisconsin scientists find genetic recipe to turn stem cells to blood 2Wisconsin scientists find genetic recipe to turn stem cells to blood 3Belize's lobster, conch, and fish populations rebuild in no-take zones 2
... space activities, a silent revolution is taking place at ... first human-rated spacecraft to be launched from Europe,s Spaceport, ... pressurised module of the largest, most complex automated spacecraft ... fulfilling the most stringent rules of human spaceflight. , ...
... to pass genes to the next generation. In sexually ... that are vital for fertility. In a new study ... researchers at Cornell University knocked down the levels of ... the males abilities to modulate egg production, sperm storage ...
... Washington University School of Medicine in St. Louis have ... plague women with urinary tract infections (UTIs) are entrenched ... controversial revision of scientists, model of how bacteria cause ... for infections get into the bladder but do not ...
Cached Biology News:Final preparations for first human-rated spacecraft to be lauched from Europe's Spaceport 2Final preparations for first human-rated spacecraft to be lauched from Europe's Spaceport 3Bacteria that cause urinary tract infections invade bladder cells 2Bacteria that cause urinary tract infections invade bladder cells 3
(Date:7/10/2014)... Burkina Faso (PRWEB) July 10, 2014 ... Faso, today have access to an additional family ... increase access to contraception at all levels of ... a lower-dose formulation of a widely used contraceptive—Pfizer’s ... system. , Burkina Faso is the first of ...
(Date:7/10/2014)... Unraveling life’s mysteries can intrigue, amaze, ... Family purchased a DNA test to unravel ... with a lifetime of memories, sharing, and closeness. In ... DNA genuinely brought the family closer together. , ... genetic history and prior to taking the genetic ...
(Date:7/10/2014)... CROWN POINT, Ind. , July 10, ... recently expanded its use of capnography for ... a growing group of healthcare leaders in ... Capnography measures how effectively patients are breathing ... respiratory depression occurs. By measuring the amount ...
(Date:7/10/2014)... --  Ceres, Inc . (Nasdaq: CERE ), ... results for the three months ended May 31, 2014 ... Ceres reported that the company and its customers have ... in Brazil, which concluded in June, despite dry and ... for part of the growing season. Yields of several ...
Breaking Biology Technology:Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 2Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 5Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 6Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9
... , BEIJING, Sept. 16 ... hospital groups, has announced it will broaden inclusion,criteria ... study will use,stem cells derived from peripheral blood ... of diabetic foot ulcers involves intensive,wound management, risk ...
... 16 /PRNewswire-FirstCall/ - AEterna Zentaris Inc. (NASDAQ: ... company focused on endocrine therapy and oncology, today announced ... its partner and licensee for perifosine in the North ... from the U.S. Food and Drug Administration (FDA) for ...
... , , , SAN ... it is relaunching its oligonucleotide radiolabeling services. TriLink discontinued the ... that the market may no longer require it. However, strong ... in September 2009. , , "We,ve learned ...
Cached Biology Technology:Indian Stem Cell Trial to Broaden Diabetic Foot Inclusion Criteria 2Indian Stem Cell Trial to Broaden Diabetic Foot Inclusion Criteria 3Indian Stem Cell Trial to Broaden Diabetic Foot Inclusion Criteria 4AEterna Zentaris Partner, Keryx Biopharmaceuticals, Receives Orphan-Drug Designation for Perifosine (KRX-0401) for the Treatment of Multiple Myeloma 2AEterna Zentaris Partner, Keryx Biopharmaceuticals, Receives Orphan-Drug Designation for Perifosine (KRX-0401) for the Treatment of Multiple Myeloma 3TriLink BioTechnologies, Inc. Relaunches Oligonucleotide Radiolabeling Services 2
Mouse IL-31 RA Biotinylated Affinity Purified PAb...
... The steadylite plus assay ... High assay sensitivity, Designed for ... Suitable for higher density microplates ... plates, Odor free, Convenient storage ...
... versatile Promega Flipper® Racks are ideal for ... small tubes. These polypropylene racks withstand extreme ... freezer storage. They may also be autoclaved ... is two-sided; one side accommodates 0.5ml microcentrifuge ...
Sf9 cells derived from Spodoptera frugiperda ovarian cells (Sf21 cells) are commonly used to isolate and propagate recombinant AcMNPV viral stocks and to produce recombinant proteins....
Biology Products: