Wistar scientists find key to keeping killer T cells in prime shape for fighting infecti...(eptor expression suggesting a cumulative...)

Date:11/30/2008

eptor expression, suggesting a cumulative impact of inhibitory receptor expression. They also found that blocking both PD-1 and LAG-3 together led to substantially greater improvement in T cell responses and viral control compared to either blockade alone.

"The goal now is to understand the pathways the receptors control, and then to learn how to fine tune reversal of exhaustion by targeting pathways that selectively control the desired type of T cell response," Wherry says.

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Contact: Staci Vernick Goldberg sgoldberg@wistar.org 215-898-3716 The Wistar Institute Source:Eurekalert

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