Navigation Links
Wistar scientists decipher structure of NatA, an enzyme complex that modifies most human proteins
Date:8/4/2013

A team of researchers from Philadelphia and Norway has determined the structure of an enzyme complex that modifies one end of most human proteins and is made at elevated levels in numerous forms of cancer. A study in Nature Structural & Molecular Biology, led by researchers at The Wistar Institute, depicts the structure and the means of action of a protein complex called NatA. Their findings, they believe, will allow them to create an inhibitora potential drugthat could knock out NatA in order to curb the growth of cancer cells.

"NatA appears essential for the growth of cells and their ability to divide, and we can see elevated production of this enzyme in many forms of cancer" said Ronen Marmorstein, Ph.D., senior author, Hilary Koprowski, M.D. Professor, and leader of The Wistar Institute Cancer Center's Gene Expression and Regulation program. "Obviously, this is a particularly appealing drug target and we are currently leveraging our recent understanding of how the protein works to develop small molecules that will bind to and inactivate NatA."

NatA is a member of a family of N-terminal acetyltransferase (NAT) enzymes (or enzyme complexes) that modify proteins in order to control their behaviorfor example by turning proteins on, telling proteins where to move, and tagging proteins or the cell for destruction.

According to Marmorstein, NatA works with an amazing specificity for a particular sequence of amino acidsthe individual building blocks of proteinsand unraveling the roots of that specificity has proven an alluring puzzle for scientists.

The Marmorstein laboratory has proven expertise in the study of acetylation enzymes, proteins that modify other molecules in the cell with an acetyl group "tag." In the cellular world, structure dictates function, and acetylation is a universal process for controlling protein behavior and gene expression in living organisms.

"Modifying protein structures is one way th
'/>"/>

Contact: Greg Lester
glester@wistar.org
215-898-3934
The Wistar Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. It takes two to tangle: Wistar scientists further unravel telomere biology
2. High folate gestational and post-weaning diets in Wistar rat offspring
3. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
4. Queens scientists seek vaccine for Pseudomonas infection
5. Scientists produce eye structures from human blood-derived stem cells
6. American Society of Plant Biologists honors early career women scientists
7. Brandeis scientists win prestigious prize for circadian rhythms research
8. Scientists discover new method of proton transfer
9. Salk scientists open new window into how cancers override cellular growth controls
10. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
11. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... of Texas at Arlington research team says recently identified ... their lab could open doors for homeland security and ... in the Oct. 1 issue of Optics Letters ... co-authors describe a new method to fabricate transparent nanoscintillators ... until a transparent ceramic is formed. A scintillator ...
(Date:9/29/2014)... University have concluded that nondigestible compounds in apples ... prevent disorders associated with obesity. The study, thought ... in apple cultivars grown in the Pacific Northwest, ... Food Chemistry ., "We know that, in ... nondigestible compounds but there are differences in varieties," ...
(Date:9/29/2014)... scientists have found compounds that boost liver detoxification enzymes ... unlikely placethe crushed seeds left after oil extraction from ... bioactive compounds in Camelina sativa seed, also ... of phytochemicals that work together synergistically far better than ... nutritional supplement because its bioactive ingredients increase the liver,s ...
Breaking Biology News(10 mins):UT Arlington researchers develop new transparent nanoscintillators for radiation detection 2UT Arlington researchers develop new transparent nanoscintillators for radiation detection 3An apple a day could keep obesity away 2New way to detox? 'Gold of Pleasure' oilseed boosts liver detoxification enzymes 2
... Society for Microbiology (ASM) sanofi-aventis ICAAC Award will ... of Oxford, United Kingdom and Mahidol University, Bangkok, ... Units, Bangkok. Supported by sanofi-aventis, the award ... of new agents, investigation of antimicrobial action or ...
... for Microbiology (ASM) ICAAC Young Investigator Award will be ... Texas A & M University, College Station. Sponsored by ... scientists for research excellence in microbiology and infectious diseases. ... pathogen, has a defined sexual cycle with two mating ...
... -- Engineers at Ohio State University have found a way ... someday replace gasoline in automobiles. The process improves on ... tank. Normally, bacteria could only produce a certain amount ... every liter of water in the tank -- before the ...
Cached Biology News:Researchers boost production of biofuel that could replace gasoline 2
(Date:9/30/2014)... (PRWEB) September 30, 2014 The custom ... ISPE Boston Product Show 2014. The Boston Area Chapter ... the 23rd annual, day-long event for Wed., Oct. 1 ... promises to be the largest in ISPE Boston’s long ... upward of 3,000 attendees expected. , HOLLOWAY AMERICA ...
(Date:9/30/2014)... SoundConnect, an award ... dedicated to supporting business communication solutions, including business ... a carrier services specialist has joined ... connected and productive at all times. This growth ... businesses to cloud communications services. On a ...
(Date:9/30/2014)... On September 11, Pharma IQ conducted an ... of a session that he will lead on “Stem Cells” ... February 17-18, 2015 in London. In the interview posted ... Sherley to respond to several questions on the current state ... stem cell toxicity, and future trends in the use of ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 Whitehouse ... been chosen by the Parenteral Drug Association (PDA) ... and 19, 2014) on container closure integrity testing. This ... integrity test methods and philosophies detailed in the recently ... Evaluation. The course will span container closure ...
Breaking Biology Technology:HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 2HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 3SoundConnect Expands Carrier Services Division 2Adult Stem Cell Technology Center, LLC Director James L. Sherley Discusses Stem Cell Toxicology 2Adult Stem Cell Technology Center, LLC Director James L. Sherley Discusses Stem Cell Toxicology 3Adult Stem Cell Technology Center, LLC Director James L. Sherley Discusses Stem Cell Toxicology 4Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 2Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 3Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 4
... 4 Wyeth (NYSE: WYE ),announced today ... 2008 Global,Pharmaceutical, Biotechnology and Medical Device Conference on ... Presenting for Wyeth will be,Geno Germano, President, U.S. ... presentation will be webcast live for investors at, ...
... Technologies, Inc.,(Nasdaq: EMIS ), a biopharmaceutical company that ... using its eligen(R) technology,today announced that the company will ... 12, 2008 at the Waldorf Astoria Hotel in New ... Officer of,Emisphere, will present for the company at 2:45 ...
... Calif., Feb. 4 AMDL, Inc. (Amex:,ADL), ... Shenzhen,Jiangxi, and Jilin, China, through its wholly ... international biopharma company that,together with Jade, engages ... pharmaceutical, health care and diagnostic products. The,Company ...
Cached Biology Technology:Wyeth to Present at the Merrill Lynch 2008 Global Pharmaceutical, Biotechnology and Medical Device Conference 2Emisphere Technologies to Present at BIO CEO & Investor Conference on February 12 2AMDL Receives a Significant Updated Appraisal of Its JJB China Production Facilities 2
...
Immunogen: Recombinant rabbit tryptophan hydroxylase, isolated as inclusion bodies from E. coli and purified by preparative SDS-PAGE. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Src cDNA Expression Kit (wild type)...
...
Biology Products: