Navigation Links
Wistar receives $1.5 million Department of Defense grant to ready prostate drug for clinical use
Date:9/12/2013

nd are currently in the clinic, they have limited activity in cancer patients. This may reflect their inability to inhibit HSP90 in mitochondria, which are protected by their own membrane. Using combinatorial chemistry, Altieri and his colleagues created a molecule that would both target HSP90 and accumulate in mitochondria.

"Gamitrinib is, essentially, a two-piece molecule, one part drives it into mitochondria and the other inhibits HSP90," said Altieri. "This became a promising drug concept, one that might apply to multiple forms of advanced cancer, because only cancer cells seem to exploit mitochondrial HSP90 in relevant amounts."

Gamitrinib exploits a critical weakness of cancer cells. While mitochondria control energy production, they also control the inherent self-destruct mechanism within cells, a process called programmed cell death or apoptosis. It is a mechanism that is relevant to many forms of metastatic cancer, and Altieri believes that, in time, the drug will be used to treat many cancers in addition to prostate cancer. Over years of study, the Altieri laboratory has demonstrated how Gamitrinib can prime cancer cell mitochondria for destruction in cell cultures and animal models for many advanced forms of cancer.

The Department of Defense grant will enable the Altieri laboratory to make the final leap between laboratory science and trials in human subjects. The funds will allow Wistar to contract with third-party research organizations to conduct the formulation, toxicology, and pharmacology studies to demonstrate the drug's effectiveness and safety in anticipation of human trials. The funds will also support the development of a suitable biomarkera biological signature that could be measured in patients to demonstrate the effectiveness of Gamitrinib-based therapy.

"In our studies we have shown the mechanism by which Gamitrinib works and potential drug combinations that will kill metastatic prostate cancer cells mo
'/>"/>

Contact: Greg Lester
glester@wistar.org
215-898-3934
The Wistar Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Wistar scientists decipher structure of NatA, an enzyme complex that modifies most human proteins
2. High folate gestational and post-weaning diets in Wistar rat offspring
3. It takes two to tangle: Wistar scientists further unravel telomere biology
4. UCSF receives $4.5M to study value of gene sequencing in newborns
5. Wayne State receives grant to reduce emissions of toxins by power plants into Great Lakes
6. International Rett Syndrome Foundation chief science officer receives prestigious military awards
7. SmartMove, Inc. receives $200,000 grant from the Colorado Office of Economic Development and International Trade
8. Wayne State receives NSF grant to develop plan for field-based water research center
9. VCU receives NIH grant to examine the biology of allergic disease
10. Carnegies Chris Field receives Max Planck Research Prize
11. Penn receives prestigious national award for breakthrough in gene therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... research presented at the Society for Integrative Oncology ... for the first time that it is possible ... readily available nutritional supplement, AHCC. ... Smith, Pharm.D., associate professor in the Department of ... of Texas Health Science Center at Houston (UTHealth) ...
(Date:10/29/2014)... on sunlight to make their food, but they also need ... scientists discovered a group of molecules in plants that shields ... Journal of the American Chemical Society , one team ... work. , Timothy Zwier and colleagues at Purdue University note ... can cause serious damage to plant DNA and, as a ...
(Date:10/29/2014)... New York City on September 19, 2014, leading geneticist ... Professor of Genome Sciences and Medicine at the University ... Philosophy of Tel Aviv University, was awarded the 2014 ... addition to her honorary degree from TAU, Prof. King ... of Medicine, and for the past 18 years she ...
Breaking Biology News(10 mins):HPV infections in women eradicated by AHCC, Japanese mushroom extract 2Geneticist and humanitarian: Prof. Mary-Claire King receives Lasker Award 2
... Scientists looking to create a potent blend of enzymes to ... have developed a test that should turbocharge their efforts. ... Molecular BioSystems , is part of a worldwide effort to ... of the food supply. It,s possible to do this today, ...
... , PHILADELPHIA - It,s well established that humans maintain ... that colonize their bodies. These organisms, collectively called the ... off pathogens, and more. There exists a long and ... composition or diversity of these bacterial populations, including cancer, ...
... from the National Cancer Centre Singapore, Duke-NUS Graduate Medical ... University (Thailand), have made a seminal breakthrough in understanding ... a rare but highly lethal form of liver cancer. ... Tan, Steve Rozen, Irinel Popescu and Vajaraphongsa Bhudhisawasdi, used ...
Cached Biology News:Crafting a better enzyme cocktail to turn plants into fuel faster 2Crafting a better enzyme cocktail to turn plants into fuel faster 3Penn researchers identify molecular link between gut microbes and intestinal health 2Penn researchers identify molecular link between gut microbes and intestinal health 3Singapore scientists expose molecular secrets of bile duct cancers from different countries 2Singapore scientists expose molecular secrets of bile duct cancers from different countries 3
(Date:10/30/2014)... Investor-Edge has initiated coverage on the following ... (NASDAQ: MDVN ), Pharmacyclics Inc. (NASDAQ: ... and Ironwood Pharmaceuticals Inc. (NASDAQ: IRWD). Free research on ... . On Wednesday, October 29, 2014, the ... Jones Industrial Average declined 0.18%, to finish the day ...
(Date:10/30/2014)... 2014 On October 26th at ... in Chicago, leading applied stem cell research scientist ... McKenna presented talks on New Techniques for Enhancing ... For Stem Cells. , Dr. Riordan focused on ... properties of AlphaGEMS that include: wound healing; inflammation ...
(Date:10/30/2014)... Ottawa, Ontario (PRWEB) October 30, 2014 ... the Spartan RX CYP2C19 System . It detects ... a non-invasive cheek swab. , The Spartan RX CYP2C19 ... medicine that has been approved in Canada. Due to ... that it may be used by healthcare professionals such ...
(Date:10/30/2014)... Isis Pharmaceuticals, Inc. (NASDAQ: ISIS ), the leader ... company overview at the Nomura Biotechnology Conference on Thursday, November ... MA. A live webcast of the ... of the Company,s website, www.isispharm.com .  A replay will ... will be archived for a limited time. About ...
Breaking Biology Technology:Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 2Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 3Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 4Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 5Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 2Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 3Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 4Health Canada approves first near-patient DNA test for personalized medicine 2Health Canada approves first near-patient DNA test for personalized medicine 3Isis Pharmaceuticals to Present at the Nomura Biotechnology Conference 2
... and simple way of making vaccines stable even ... by scientists at Oxford University. The British technology, ... need for fridges, freezers and associated health infrastructure. It ... in the developing world where infectious diseases kill millions ...
... ... , ... 2010 -- iCorps Technologies , a leader in delivering solid, business-driven IT solutions ... Technology Industry Association (CompTIA) is the leading trade association for the world,s information technology ...
... , Feb. 17 Anpath Group, Inc. (OTC Bulletin ... financial results for its fiscal 2010 third quarter which ended ... , The Company continued a positive trend of increased ... third quarter were $66,988 compared with revenues of ...
Cached Biology Technology:New method makes vaccines stable at tropical temperatures 2New method makes vaccines stable at tropical temperatures 3iCorps Technologies Earns CompTIA Security Trustmark™ 2iCorps Technologies Earns CompTIA Security Trustmark™ 3Anpath Group, Inc. Announces Fiscal 2010 Third Quarter Results 2Anpath Group, Inc. Announces Fiscal 2010 Third Quarter Results 3Anpath Group, Inc. Announces Fiscal 2010 Third Quarter Results 4
Rabbit monoclonal [E227] to ZAP70 (phospho Y319) ( Abpromise for all tested applications). Antigen: Synthetic phospho peptide corresponding to residues surrounding Tyr319 of human ZAP70 Entre...
C/EBPalpha Antibody Shipping Temperature: Cold Storage Temperature: -20C...
Mouse monoclonal [GB3] to Kalinin ( Abpromise for all tested applications). entrezGeneID: 3918 SwissProtID: Q13753...
Rabbit polyclonal to VEZT ( Abpromise for all tested applications). Antigen: Full length human VEZT conjugated to GST Entrez Gene ID: 55591 Swiss Protein ID: Q9HBM0...
Biology Products: