Navigation Links
Wistar receives $1.5 million Department of Defense grant to ready prostate drug for clinical use
Date:9/12/2013

nd are currently in the clinic, they have limited activity in cancer patients. This may reflect their inability to inhibit HSP90 in mitochondria, which are protected by their own membrane. Using combinatorial chemistry, Altieri and his colleagues created a molecule that would both target HSP90 and accumulate in mitochondria.

"Gamitrinib is, essentially, a two-piece molecule, one part drives it into mitochondria and the other inhibits HSP90," said Altieri. "This became a promising drug concept, one that might apply to multiple forms of advanced cancer, because only cancer cells seem to exploit mitochondrial HSP90 in relevant amounts."

Gamitrinib exploits a critical weakness of cancer cells. While mitochondria control energy production, they also control the inherent self-destruct mechanism within cells, a process called programmed cell death or apoptosis. It is a mechanism that is relevant to many forms of metastatic cancer, and Altieri believes that, in time, the drug will be used to treat many cancers in addition to prostate cancer. Over years of study, the Altieri laboratory has demonstrated how Gamitrinib can prime cancer cell mitochondria for destruction in cell cultures and animal models for many advanced forms of cancer.

The Department of Defense grant will enable the Altieri laboratory to make the final leap between laboratory science and trials in human subjects. The funds will allow Wistar to contract with third-party research organizations to conduct the formulation, toxicology, and pharmacology studies to demonstrate the drug's effectiveness and safety in anticipation of human trials. The funds will also support the development of a suitable biomarkera biological signature that could be measured in patients to demonstrate the effectiveness of Gamitrinib-based therapy.

"In our studies we have shown the mechanism by which Gamitrinib works and potential drug combinations that will kill metastatic prostate cancer cells mo
'/>"/>

Contact: Greg Lester
glester@wistar.org
215-898-3934
The Wistar Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Wistar scientists decipher structure of NatA, an enzyme complex that modifies most human proteins
2. High folate gestational and post-weaning diets in Wistar rat offspring
3. It takes two to tangle: Wistar scientists further unravel telomere biology
4. UCSF receives $4.5M to study value of gene sequencing in newborns
5. Wayne State receives grant to reduce emissions of toxins by power plants into Great Lakes
6. International Rett Syndrome Foundation chief science officer receives prestigious military awards
7. SmartMove, Inc. receives $200,000 grant from the Colorado Office of Economic Development and International Trade
8. Wayne State receives NSF grant to develop plan for field-based water research center
9. VCU receives NIH grant to examine the biology of allergic disease
10. Carnegies Chris Field receives Max Planck Research Prize
11. Penn receives prestigious national award for breakthrough in gene therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... Calif. The National Institutes of Health (NIH) ... today to develop an electrode array system that ... brain works through unprecedented resolution and scale. , ... to support President Obama,s BRAIN (Brain Research ... research effort to revolutionize our understanding of the ...
(Date:9/30/2014)... live in almost any aquatic environment on Earth, but ... species are pushed to the limit. The amount of ... critical for how different species cope in the future, ... of Gothenburg, published in the scientific journal Proceedings ... continues apace thanks to increasing levels of greenhouse gases ...
(Date:9/30/2014)... want your doctor to know what goes wrong with your ... idea to know what "normal" actually is. That,s where a ... the FASEB Journal comes in. In ... key set of molecules that can help scientists "see" which ... What,s more, they found never-before-detected gene activity and that men ...
Breaking Biology News(10 mins):NIH taps lab to develop sophisticated electrode array system to monitor brain act 2NIH taps lab to develop sophisticated electrode array system to monitor brain act 3Shape up quickly -- applies to fish, too! 2Scientists identify which genes are active in muscles of men and women 2
... paleobiologist J. William Schopf and colleagues have produced 3-D images ... old -- preserved in rocks, an achievement that has never ... Mars brings rocks back to Earth, Schopf said the techniques ... spectroscopy, could enable scientists to look at microscopic fossils inside ...
... National Jewish Medical and Research Center report in the ... promising proteins, known as fibulins 3 and 5, slow ... blood vessels from sprouting. The proteins are promising candidates ... produce fibulin proteins, which regulate cell proliferation, migration and ...
... be potentially life threatening in the home, but the presence ... Mike Steven and colleagues from the University of Nottingham have ... act as an early warning of leaks in natural gas ... satellite remote systems to monitor gas leaks via the spectrum ...
Cached Biology News:Inside rocks, implications for finding life on Mars 2Proteins stop blood-vessel and tumor growth in mice 2Plants used to detect gas leaks, from outer space! 2
(Date:9/30/2014)... Using a bio-mimicking analog of one of ... an international research team led by Alejandro Briseno ... a major step in developing long-sought polymer architecture ... for use in electronic devices. , Briseno, ... and others at Stanford University and Dresden University ...
(Date:9/30/2014)... 30, 2014 Nematicide is a type ... are microscopic parasitic roundworms, found in massive quantities ... plants and animals. Nematicides have tended to be ... promoting migration through the soil. A single gram ... nematodes. With more than 10,000 species classified, they ...
(Date:9/30/2014)... Sept. 30, 2014  RegeneRx Biopharmaceuticals, Inc. (OTC: ... it has received a Canadian Patent for Inhibition ... This patent includes claims using thymosin beta 4, ... peptides for these purposes.  The patent will expire ... Inc. ( www.regenerx.com ) RegeneRx ...
(Date:9/30/2014)... Angeles, CA (PRWEB) September 30, 2014 ... (EWS), the high-speed, chemical-free process to clean up large ... to shareholders, CEO Riggs Eckelberry reported on the launch ... Texas, at a site provided by partner STW ... up to 1000 barrels per day (bpd) and achieved ...
Breaking Biology Technology:Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3Nematicides Market by Types (Fumigants, Organophosphates, Carbamate and Bio-Nematicides), Applications (Agrochemicals, Industrial, and Others), and Geography (North America, Europe, Asia-Pacific & ROW) - Global Trends & Forecasts to 2019 2RegeneRx Receives Canadian Patent for Inhibition or Reversal of Skin Aging 2OriginOil, Inc. Report to Shareholders: Blue Gold in West Texas 2
... Biotechnologies AB, an,atherosclerosis R&D company developing novel products ... today that it has,signed two distributor agreements - ... Ltd. , Carina Schmidt, ... about the,opportunities these agreements present to Athera. They ...
... that Understanding the Fundamental Mechanism of Angiogenesis is ... - AAmgen Launches Angiogenesis Website THOUSAND OAKS, Calif., ... ) today announced that results from several preclinical ... presented at the 2009 American Association for Cancer ...
... SAN FRANCISCO, Calif., April 16 Proteolix, Inc. today ... post of Senior Vice President, Finance and Corporate Development ... the company,s clinical development and regulatory leadership team with ... the post of Chief Medical Officer (CMO) and Albert ...
Cached Biology Technology:Athera Signs Agreements With German and UK Distributors for New Cardiovascular Biomarker 2Athera Signs Agreements With German and UK Distributors for New Cardiovascular Biomarker 3Preclinical Data From Amgen's Oncology Pipeline to be Presented at AACR 2Preclinical Data From Amgen's Oncology Pipeline to be Presented at AACR 3Preclinical Data From Amgen's Oncology Pipeline to be Presented at AACR 4Preclinical Data From Amgen's Oncology Pipeline to be Presented at AACR 5Preclinical Data From Amgen's Oncology Pipeline to be Presented at AACR 6Preclinical Data From Amgen's Oncology Pipeline to be Presented at AACR 7Proteolix Announces New Appointment in Finance and Expands Clinical and Regulatory Leadership Team 2Proteolix Announces New Appointment in Finance and Expands Clinical and Regulatory Leadership Team 3Proteolix Announces New Appointment in Finance and Expands Clinical and Regulatory Leadership Team 4
... This CLS number ... number, created to easily ... If showing no availability ... the old Sigma-Aldrich number ...
This CLS number is a new product number, created to easily match Cornings product number. If showing no availability yet, please order under the old Sigma-Aldrich number (E6027) or contact customer s...
... pressure gradient system uses three Adept CE ... a flow rate in one microlitre increaments. ... added flexibility. System control and data processing ... interface unit, CE 4900., Column heater/chillers can be ...
... of large numbers of samples may be carried ... minimum operator attention. System control and data ... CE 4900. The elegant, powerful and very ... and Windows 98 and 2000., The supplied detector ...
Biology Products: