Navigation Links
Wisconsin Center of Excellence in Genomics Science established
Date:9/28/2009

and used by the millions of cells in our body. Recent development of novel technologies allows us to study how individual proteins bind and interact with the DNA across the entire genome, and how this interaction varies in different cell types and under different conditions. Unfortunately, this approach only works with proteins that are already known. What is needed, and what we will develop in this Center, is technology that is able to identify all of the proteins that are interacting with the genome, even if we do not know in advance what their function may be."

According to Dr. Smith, "We want to know what sets of genes are turned on and off, and how this is coordinated and controlled. We have DNA sequences for so many organisms, but the big question now is figuring out what they are doing. We have the blueprints, but we don't know how to read them, and gene regulation is front and center to that problem. Can we find the rules for when genes are turned on and off?"

Rather than using the traditional approach of identifying the DNA sequences where regulatory factors bind, the Center will develop novel technologies that identify the proteins that bind to particular DNA regions. Through this approach, investigators may be able to identify entirely new regulatory proteins. The researchers' ultimate goal is to develop a toolbox that can be used to better understand the relationship between changes in protein-DNA interactions and the underlying complex machinery controlling genes. Their approach combines DNA chip technology with very powerful and highly sensitive new instruments for identifying proteins.

"When we figure that out, we can use the information to understand what the rules are; without this information, we are flying blind," says Dr. Smith.

The work of the new Center builds on a long-standing collaboration between the groups at the Medical College and UW-Madison as part of their joint NIH-supported National Center of Proteomics Researc
'/>"/>

Contact: Toranj Marphetia
toranj@mcw.edu
414-456-4744
Medical College of Wisconsin
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Wisconsin Governor Jim Doyle to receive Regional Policy Award from ESA
2. Scattered nature of Wisconsins woodlands could complicate forests response to climate change
3. Wisconsin researchers describe how digits grow
4. Distinctive Voices@The Beckman Center announces fall lecture series
5. LSU receives $3.6 million to fund center studying hazardous waste cleanup and health impacts
6. UTSA wins $5 million for new Simulation, Visualization and Real-Time Prediction Center
7. New collaborative center to provide education, research on temperate rainforests
8. SRI announces selection by the National Cancer Institute as a Chemical Biology Consortium center
9. Kornberg Associates Architects Selected to Develop Design for New Stanford University Imaging Center
10. 2 Fred Hutchinson Cancer Research Center scientists receive Presidential Early Career Award
11. New national genome center launched
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... addition to the hippocampus, the marginal division of ... memory. What is the impact degree of substance ... and memory function? Yan Yu and his team, ... found, using immunofluorescence staining, that substance P receptor, ... and striatal marginal division of normal rats. Unilateral ...
(Date:7/11/2014)... de Janeiro, Brazil- In the brains of all ... that allows an electric or chemical signal to ... Chemical synapses, which are the most abundant type ... Synapse formation is crucial for learning, memory, perception ... inhibitory synapses critical for brain function. For ...
(Date:7/10/2014)... July 1, 2014 Smart technology emphasis ... convenience and improved security: NXT-ID, Inc. (OTCBB: NXTD), eBay Inc. ... GOOG ), Apple Inc. (NASDAQ: AAPL ), Visa ... MA) NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication company ... that the second series of 30 second spots on CNBC ...
Breaking Biology News(10 mins):Blame it on the astrocytes 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 4Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 5
... known already for its role in schizophrenia ... according to a report in todays advance on-line issue ... Deaconess Medical Center (BIDMC), the study further suggests that ... diagnostic marker and therapeutic supplement for the treatment of ...
... which glows under ultraviolet light have shown that up ... cleaned. Their findings, published in BioMed Centrals journal, BMC ... bacteria Clostridium difficile (C. difficile) linger in the loo ... Michelle Alfa and a team of scientists from Manitoba, ...
... technology, DALLAS, May 7 An innovator ... will provide its proven public key,infrastructure to the ... on machine readable travel documents (MRTDs),-- also known ... nearly 23 million,citizens by the end of 2008., ...
Cached Biology News:A new gene trigger for pregnancy disorder identified 2UV lotion lights the way to cleaner facilities 2Entrust, Hewlett Packard Partner to Deploy Taiwanese ePassports, Authenticate Biometric Data 2Entrust, Hewlett Packard Partner to Deploy Taiwanese ePassports, Authenticate Biometric Data 3
(Date:7/10/2014)... July 10, 2014 Senior supply chain ... professional associations, addressed the challenges of “Reducing Cost, Lead ... Industries” through strategic sourcing. Describing the partnership of the ... Supply Chain Management Institute ( SCMI) of the ... June 24 at the Kroc Institute of Peace and ...
(Date:7/10/2014)... , July 10, 2014  Kainos Capital, a firm ... today announced that it has acquired the Slim-Fast brand ... the business. Terms of the transaction were not disclosed. ... meal replacement business that markets ready-to-drink shakes, powders, bars ... America and in the United ...
(Date:7/10/2014)... THOUSAND OAKS, Calif., July 10, 2014   Ceres, ... biotechnology and seed company, announced today financial results for ... an update on its business. Ceres reported ... progress in product performance this growing season in Brazil, ... that affected the company,s sorghum evaluation areas for part ...
(Date:7/10/2014)... WASHINGTON D.C., June 17, 2014 Using microscopic ... of specific gases, researchers at MIT,s Quantum Photonics ... detection levels in the parts-per-billion range. Optical sensors ... to their high signal-to-noise ratio, compact, lightweight nature, ... optical gas sensors had been developed before, the ...
Breaking Biology Technology:Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Kainos Capital Acquires Slim-Fast From Unilever 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9Swell new sensors 2
... simultaneously with the tempest thermoshaker , Jeff Braman ,Stratagene , ... 1: The tempest Thermoshaker , , ... and a 96-deep-well, round-bottom plate were used ... format. Early- and mid-log phase rates of bacterial growth, ...
... system for inducible mammalian expression , , ... control mammalian expression,system ... a wide range of mammalian cell types. The,inducible promoter ... absence of,the ecdysone analog ponasterone A (ponA). In a ...
... ,Economical quantitative PCR (QPCR) reagent kits ... , Gothami Padmabandu Lisa Grismer ... quantitative PCR and RT-PCR core,reagent kits ... Several versions have been created to optionally ...
Cached Biology Technology:High-Throughput Cultivation of Bacterial Clones 2High-Throughput Cultivation of Bacterial Clones 3Versatile Vectors for Ponasterone A- Inducible Control of Gene Expression in,Mammalian Cells 2Versatile Vectors for Ponasterone A- Inducible Control of Gene Expression in,Mammalian Cells 3Versatile Vectors for Ponasterone A- Inducible Control of Gene Expression in,Mammalian Cells 4Versatile Vectors for Ponasterone A- Inducible Control of Gene Expression in,Mammalian Cells 5Versatile Vectors for Ponasterone A- Inducible Control of Gene Expression in,Mammalian Cells 6Versatile Vectors for Ponasterone A- Inducible Control of Gene Expression in,Mammalian Cells 7Versatile Vectors for Ponasterone A- Inducible Control of Gene Expression in,Mammalian Cells 8Brilliant Core Reagent Kits for QPCR and QRT-PCR 2Brilliant Core Reagent Kits for QPCR and QRT-PCR 3Brilliant Core Reagent Kits for QPCR and QRT-PCR 4Brilliant Core Reagent Kits for QPCR and QRT-PCR 5Brilliant Core Reagent Kits for QPCR and QRT-PCR 6Brilliant Core Reagent Kits for QPCR and QRT-PCR 7Brilliant Core Reagent Kits for QPCR and QRT-PCR 8Brilliant Core Reagent Kits for QPCR and QRT-PCR 9Brilliant Core Reagent Kits for QPCR and QRT-PCR 10Brilliant Core Reagent Kits for QPCR and QRT-PCR 11Brilliant Core Reagent Kits for QPCR and QRT-PCR 12Brilliant Core Reagent Kits for QPCR and QRT-PCR 13Brilliant Core Reagent Kits for QPCR and QRT-PCR 14
... Edited by N.C. Price (1996) ... information on protein chemistry and ... of proteins. Data on the ... crystalization, size determination, amino acid ...
... B.S. Dunbar (1994) • This ... principles and methods for preparing samples ... such as radiometric and bioluminescence-enhanced detection ... covered are, the detection and characterization ...
See product name for description....
RAT ANTI MOUSE TCR V BETA 7:RPE Immunogen: T-cell lymphoma TK1...
Biology Products: