Navigation Links
Will this be the end of hamburger disease?
Date:11/29/2010

This release is available in French.

Montreal, November 25, 2010 Hamburger disease, a debilitating form of food poisoning, may be a thing of the past. New findings from an international research collaboration conducted by the French National Institute for Agronomic Research (INRA), involving the Universit de Montral are the first to show how the contaminating E.coli bacterium is able to survive in the competitive environment of a cow's intestine by scavenging specific food sources. Published in this month's Environmental Microbiology, and featured in Nature Reviews Microbiology, this study may lead to non-medicinal methods for eradicating this invasive bug.

"We studied E.coli O157:H7, which is the most prevalent species of bacteria associated with larger outbreaks," says Jose Harel, co-author of the study and director of the Groupe de Recherche sur les Maladies Infectieuses du Porc at the Universit de Montral's Faculty of Veterinary Medicine. "These outbreaks have been associated with direct contact with the farm environment and with the consumption of meat, raw milk and dairy products. Reduction or eradication of O157:H7 in cows will lead to a substantial decrease in food contamination and consequential human infections."

O157:H7, a wily bacteria

The intestine is a complex environment with a high number and diversity of bacteria. Most of these bugs are not harmful and many contribute to proper bowel function. However, your guts are a battleground for wars between these species as they engage in a struggle to obtain carbon, nitrogen and other energy sources. Those that win the battle for resources survive and multiply while the losers disappear.

Harel and her collaborators' from France's Institut National de la Recherche Agronomique and Lallemand Animal Nutrition, first step was to demonstrate that O157:H7 does in fact thrive in the bovine intestine. Once this was established, they went on to determine why these particular bacteria find the cow intestine such a great place to live. They found that O157:H7 is unusual because it can forage nitrogen from ethanolamine, a chemical present in the cow's intestine. Because other bacteria cannot process ethanolamine, O157:H7 has this source of nutrition to itself. "The ability of O157:H7 to use ethanolamine as a source of nitrogen gives it the nutritional and competitive advantage to survive," says Harel.

It is all in the genes

The final step for Harel and colleagues was to determine how O157:H7 was able to process the ethanolamine so it could be used as a nitrogen source. Genetic analyses revealed that 0157:H7 had specific genes that allowed it to do so.

"We now know that this bacteria has evolved a genetic program that allows it to process ethanolamine and therefore outcompete its neighbours and survive and multiply in the intestine," says Harel. "This new-found knowledge will help us select appropriate feed or probiotics in an attempt to eliminate the food source of this contaminating bug. This in turn, should limit the spread of this bug into the food chain."

About hamburger disease:

Hamburger disease, otherwise known as haemolytic uremic syndrome, can occur after a person has been infected with the E. coli O157:H7. It can result in the destruction of cells that cause clotting of the blood and red blood cells. Kidney failure may result due to the damage of the small blood vessels and tubules in the kidneys. It usually affects children between the ages of 1 and 10 years, but may also occur in adults. HUS affects 2 to 4 people per 100 000 and occurs all over the world.


'/>"/>

Contact: Julie Gazaille
j.cordeau-gazaille@umontreal.ca
514-343-6796
University of Montreal
Source:Eurekalert

Related biology news :

1. Think saturated fat contributes to heart disease? Think again
2. Can an over-the-counter vitamin-like substance slow the progression of Parkinsons disease?
3. How much omega-3 fatty acid do we need to prevent cardiovascular disease?
4. Toward an explanation for Crohns disease?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:4/24/2017)... -- Janice Kephart , former 9/11 Commission ... LLP (IdSP) , today issues the following statement: ... 6, 2017 Executive Order: Protecting the Nation ... instilled with greater confidence, enabling the reactivation of ... are suspended by until at least July 2017). ...
(Date:4/13/2017)... 2017 According to a new market research report ... Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region ... expected to grow from USD 14.30 Billion in 2017 to USD 31.75 ... ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... York, NY (PRWEB) , ... October 12, 2017 ... ... Academy of Sciences today announced the three Winners and six Finalists of the ... are given annually by the Blavatnik Family Foundation and administered by the New ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... first-ever genomics analysis platform specifically designed for life science researchers to analyze ... pioneering researcher Rosalind Franklin, who made a major contribution to the discovery ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... today it will be hosting a Webinar titled, “Pathology is going digital. Is ... , on digital pathology adoption best practices and how Proscia improves lab economics ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator ... osteosarcoma. SBT-100 is able to cross the cell membrane and bind intracellular STAT3 ...
Breaking Biology Technology: