Navigation Links
Will this be the end of hamburger disease?
Date:11/29/2010

This release is available in French.

Montreal, November 25, 2010 Hamburger disease, a debilitating form of food poisoning, may be a thing of the past. New findings from an international research collaboration conducted by the French National Institute for Agronomic Research (INRA), involving the Universit de Montral are the first to show how the contaminating E.coli bacterium is able to survive in the competitive environment of a cow's intestine by scavenging specific food sources. Published in this month's Environmental Microbiology, and featured in Nature Reviews Microbiology, this study may lead to non-medicinal methods for eradicating this invasive bug.

"We studied E.coli O157:H7, which is the most prevalent species of bacteria associated with larger outbreaks," says Jose Harel, co-author of the study and director of the Groupe de Recherche sur les Maladies Infectieuses du Porc at the Universit de Montral's Faculty of Veterinary Medicine. "These outbreaks have been associated with direct contact with the farm environment and with the consumption of meat, raw milk and dairy products. Reduction or eradication of O157:H7 in cows will lead to a substantial decrease in food contamination and consequential human infections."

O157:H7, a wily bacteria

The intestine is a complex environment with a high number and diversity of bacteria. Most of these bugs are not harmful and many contribute to proper bowel function. However, your guts are a battleground for wars between these species as they engage in a struggle to obtain carbon, nitrogen and other energy sources. Those that win the battle for resources survive and multiply while the losers disappear.

Harel and her collaborators' from France's Institut National de la Recherche Agronomique and Lallemand Animal Nutrition, first step was to demonstrate that O157:H7 does in fact thrive in the bovine intestine. Once this was established, they went on to determine why these particular bacteria find the cow intestine such a great place to live. They found that O157:H7 is unusual because it can forage nitrogen from ethanolamine, a chemical present in the cow's intestine. Because other bacteria cannot process ethanolamine, O157:H7 has this source of nutrition to itself. "The ability of O157:H7 to use ethanolamine as a source of nitrogen gives it the nutritional and competitive advantage to survive," says Harel.

It is all in the genes

The final step for Harel and colleagues was to determine how O157:H7 was able to process the ethanolamine so it could be used as a nitrogen source. Genetic analyses revealed that 0157:H7 had specific genes that allowed it to do so.

"We now know that this bacteria has evolved a genetic program that allows it to process ethanolamine and therefore outcompete its neighbours and survive and multiply in the intestine," says Harel. "This new-found knowledge will help us select appropriate feed or probiotics in an attempt to eliminate the food source of this contaminating bug. This in turn, should limit the spread of this bug into the food chain."

About hamburger disease:

Hamburger disease, otherwise known as haemolytic uremic syndrome, can occur after a person has been infected with the E. coli O157:H7. It can result in the destruction of cells that cause clotting of the blood and red blood cells. Kidney failure may result due to the damage of the small blood vessels and tubules in the kidneys. It usually affects children between the ages of 1 and 10 years, but may also occur in adults. HUS affects 2 to 4 people per 100 000 and occurs all over the world.


'/>"/>

Contact: Julie Gazaille
j.cordeau-gazaille@umontreal.ca
514-343-6796
University of Montreal
Source:Eurekalert

Related biology news :

1. Think saturated fat contributes to heart disease? Think again
2. Can an over-the-counter vitamin-like substance slow the progression of Parkinsons disease?
3. How much omega-3 fatty acid do we need to prevent cardiovascular disease?
4. Toward an explanation for Crohns disease?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... Feb. 2, 2016 Checkpoint Inhibitors for ... Market Are you interested in the future ... for checkpoint inhibitors. Visiongain,s report gives those predictions ... and national level. Avoid falling behind in ... opportunities and revenues those emerging cancer therapies can ...
(Date:2/2/2016)... Calif. , Feb. 2, 2016  Based ... market, Frost & Sullivan recognizes US-based Intelligent Retinal ... Frost & Sullivan Award for New Product Innovation. ... in North America , is ... the rapidly growing diabetic retinopathy market. The IRIS ...
(Date:2/1/2016)... -- Wocket® smart wallet ( www.wocketwallet.com ) announces the launch of a new ... Las Vegas , where Joey appeared at the ... Las Vegas , where Joey appeared at the Wocket booth to ... was filmed at the Consumer Electronics Show (CES2016) in Las ... and greet fans. --> --> ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... 11, 2016  Bioethics International, a not-for-profit organization focused on ... marketed and made accessible to patients around the world, today ... named the publication of the Good Pharma Scorecard ... also featured as one of BMJ Open ,s ,Most ... that are most frequently read. Ed Sucksmith , ...
(Date:2/11/2016)... SANTA CRUZ, Calif. , Feb. 11, 2016 /PRNewswire/ ... accepting applications to its beta program for a planned ... co-founder, will present the company,s metagenomic genome assembly method ... 2016 Advances in Genome Biology & Technology conference in ... novo  assembly of these highly complex datasets is difficult. ...
(Date:2/11/2016)... MIAMI (PRWEB) , ... February 11, 2016 , ... ... in regenerative medicine, has announced a new agreement with Bankok,Thailand-based Global Stem Cells ... researchers and phsyicians in 15 Latin American countries, including Mexico, Costa Rica, Dominican ...
(Date:2/10/2016)... 2016  The Maryland House of Delegates and House ... University of Maryland School of Medicine Dean E. ... Maryland Medical System President and CEO Robert Chrencik ... highest honor given to the public by the leader ... Reece and Mr. Chrencik for their contributions to ...
Breaking Biology Technology: