Navigation Links
Why the craving for cocaine won't go away
Date:9/16/2010

People who have used cocaine run a great risk of becoming addicted, even after long drug-free periods. Now researchers at Linkping University and their colleagues can point to a specific molecule in the brain as a possible target for treatment to prevent relapses.

Drugs are addictive because they "hijack" the brain's reward system, which is actually intended to make it pleasurable to eat and have sex, behaviors that are necessary for survival and reproduction.

This "hijacking" is extremely long-lived and often leads to relapses into abuse, especially when the individual is exposed to stimuli in the surroundings that are associated with the drug. In an article in the prestigious Journal of Neuroscience the research team can now show that a receptor for the signal substance glutamate (mGluR5), in a part of the brain called the striatum, plays a major role in relapses.

The study, led by David Engblom, associate professor of neurobiology at Linkping University in Sweden, looks at what happens in individuals who lack the glutamate receptor. The experiments were performed on mice that were taught to ingest cocaine.

"Our findings show that the mice who lacked the receptor were less prone to relapse. This is due the fact that their reaction to reward had not been etched into their memories in the same ways as in normal mice. The receptor seems to be a prerequisite for objects or environments that were previously associated with taking drugs, or something else rewarding, to create a craving," says David Engblom.

He hopes that these findings and other studies of mechanisms underlying drug addiction can lead to forms of treatment based on what goes wrong in the brain of an addict.


'/>"/>

Contact: ke Hjelm
ake.hjelm@liu.se
Swedish Research Council
Source:Eurekalert

Page: 1

Related biology news :

1. The psychology of food cravings
2. Scripps Research scientists uncover possible cocaine addiction trigger
3. Study shows compulsive eating shares addictive biochemical mechanism with cocaine, heroin abuse
4. A new ally in the battle against cocaine addiction
5. Why cant some people give up cocaine?
6. Cocaine: Perceived as a reward by the brain?
7. Early isolation linked to enhanced response to cocaine
8. Early isolation linked to enhanced response to cocaine
9. Honeybees succumb to cocaines allure
10. Honey bees on cocaine dance more, changing ideas about the insect brain
11. UNC, Yale partner to study effects of cocaine use on mother-infant relationships
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/15/2017)...   ivWatch LLC , a medical device company focused on ... receipt of its ISO 13485 Certification, the global standard for medical ... Standardization (ISO®). ... Continuous Monitoring device for the early detection of IV infiltrations. ... "This is an important milestone for ivWatch, as ...
(Date:7/20/2017)... July 20, 2017 Delta (NYSE: DAL ) customers ... Delta aircraft at Reagan Washington National Airport (DCA). ... Delta launches biometrics to board aircraft ... Delta,s biometric boarding pass ... is now integrated into the boarding process to allow eligible Delta ...
(Date:6/30/2017)... 30, 2017 Today, American Trucking Associations ... of face and eye tracking software, became the ... program. "Artificial intelligence and advanced ... monitor a driver,s attentiveness levels while on the ... to detect fatigue and prevent potential accidents, which ...
Breaking Biology News(10 mins):
(Date:8/23/2017)... ... 22, 2017 , ... Mettler-Toledo, one of the market leaders in product inspection ... This turnkey system inspects labels, prints, and packaging properties fully automatically, and, thanks to ... and extended as needed. , The high-end version of the V2630 was shown ...
(Date:8/23/2017)... ... August 22, 2017 , ... Today, Metabiota , ... Re , one of the world’s leading reinsurers and expert on global risk ... development of technologies to support the U.S. intelligence community, have signed strategic agreements ...
(Date:8/23/2017)... ... , ... Patients suffering from gum disease and failing implants now have a ... Malik, of Broward Center for Laser Periodontics and Implants , joins the ... dentistry with regenerative periodontal procedures. , "I initially became LANAP trained ...
(Date:8/23/2017)... ... , ... Having proven that its Disruptor™ technology is more ... Green Cell Technologies® (GCT®), has turned its attention to the lucrative fruit ... methods, ushering in a new era of modern, cost effective and more natural ...
Breaking Biology Technology: