Navigation Links
Why the craving for cocaine won't go away
Date:9/16/2010

People who have used cocaine run a great risk of becoming addicted, even after long drug-free periods. Now researchers at Linkping University and their colleagues can point to a specific molecule in the brain as a possible target for treatment to prevent relapses.

Drugs are addictive because they "hijack" the brain's reward system, which is actually intended to make it pleasurable to eat and have sex, behaviors that are necessary for survival and reproduction.

This "hijacking" is extremely long-lived and often leads to relapses into abuse, especially when the individual is exposed to stimuli in the surroundings that are associated with the drug. In an article in the prestigious Journal of Neuroscience the research team can now show that a receptor for the signal substance glutamate (mGluR5), in a part of the brain called the striatum, plays a major role in relapses.

The study, led by David Engblom, associate professor of neurobiology at Linkping University in Sweden, looks at what happens in individuals who lack the glutamate receptor. The experiments were performed on mice that were taught to ingest cocaine.

"Our findings show that the mice who lacked the receptor were less prone to relapse. This is due the fact that their reaction to reward had not been etched into their memories in the same ways as in normal mice. The receptor seems to be a prerequisite for objects or environments that were previously associated with taking drugs, or something else rewarding, to create a craving," says David Engblom.

He hopes that these findings and other studies of mechanisms underlying drug addiction can lead to forms of treatment based on what goes wrong in the brain of an addict.


'/>"/>

Contact: ke Hjelm
ake.hjelm@liu.se
Swedish Research Council
Source:Eurekalert

Page: 1

Related biology news :

1. The psychology of food cravings
2. Scripps Research scientists uncover possible cocaine addiction trigger
3. Study shows compulsive eating shares addictive biochemical mechanism with cocaine, heroin abuse
4. A new ally in the battle against cocaine addiction
5. Why cant some people give up cocaine?
6. Cocaine: Perceived as a reward by the brain?
7. Early isolation linked to enhanced response to cocaine
8. Early isolation linked to enhanced response to cocaine
9. Honeybees succumb to cocaines allure
10. Honey bees on cocaine dance more, changing ideas about the insect brain
11. UNC, Yale partner to study effects of cocaine use on mother-infant relationships
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2016)... 2016 Research and Markets has ... Market 2016-2020,"  report to their offering.  , ... ,The global gait biometrics market is expected to ... period 2016-2020. Gait analysis generates multiple ... used to compute factors that are not or ...
(Date:3/31/2016)... R.I. , March 31, 2016  Genomics firm ... of founding CEO, Barrett Bready , M.D., who ... members of the original technical leadership team, including Chief ... President of Product Development, Steve Nurnberg and Vice President ... returned to the company. Dr. Bready served ...
(Date:3/22/2016)... , PROVO and ... Newborn Screening Ontario (NSO), which operates the highest sample ... molecular testing, and Tute Genomics and UNIConnect, leaders in ... respectively, today announced the launch of a project to ... (NGS) testing panel. NSO has been ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , ... June 23, 2016 , ... STACS DNA Inc., ... Leader at the Arkansas State Crime Laboratory, has joined STACS DNA as a Field ... DNA team,” said Jocelyn Tremblay, President and COO of STACS DNA. “In further expanding ...
(Date:6/23/2016)... June 23, 2016  Blueprint Bio, a company dedicated ... the medical community, has closed its Series A funding ... . "We have received a commitment from ... we need to meet our current goals," stated ... the runway to complete validation on the current projects ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... exhibiting at the Pennsylvania Convention Center and will showcase its product’s latest features ... will also be presenting a scientific poster on Disrupting Clinical Trials in The ...
(Date:6/23/2016)... 22, 2016  Amgen (NASDAQ: AMGN ) ... QB3@953 life sciences incubator to accelerate the development ... laboratory space at QB3@953 was created to help high-potential ... for many early stage organizations - access to laboratory ... Amgen launched two "Amgen Golden Ticket" awards, providing each ...
Breaking Biology Technology: