Navigation Links
Why the biological clock? Penn study says aging reduces centromere cohesion, disrupts reproduction
Date:9/8/2010

PHILADELPHIA - University of Pennsylvania biologists studying human reproduction have identified what is likely the major contributing factor to the maternal age-associated increase in aneuploidy, the term for an abnormal number of chromosomes during reproductive cell division.

Using naturally aging mouse models, researchers showed that this basic fact of reproductive life is most likely caused by weakened chromosome cohesion. Older oocytes, or egg cells, have dramatically reduced amounts of a protein, REC8, that is essential for chromosomes to segregate correctly during the process that forms an egg. Mistakes in this process can create chromosomal abnormalities like Down syndrome.

Richard Schultz, associate dean for the natural sciences and the Charles and William L. Day Distinguished Professor of Biology in Penn's School of Arts and Sciences, and Michael Lampson, assistant professor of biology, found that kinetochores the protein structures that mark the site where a chromosome pair is split during cell division are farther apart in eggs obtained from aged mice, resulting in reduced centromere cohesion. Because cohesion in these cells is established during fetal development, and must remain functional until meiotic resumption in adult life (up to ~50 years later in humans or 15 months in mice), defective cohesion is a good candidate for a process that might fail with increasing maternal age.

Researchers demonstrated that about 90 percent of age-related aneuploidies are best explained by weakened centromere cohesion. Together, these results show that the maternal age-associated increase in aneuploidy is often due to a failure to effectively replace cohesin proteins lost during aging.

"Despite the well understood nature of the issue popularly called the biological clock the molecular mechanisms that underpin this phenomenon have never been fully understood," Schultz said. "Even now at the molecular level, there is n
'/>"/>

Contact: Jordan Reese
jreese@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Biological sand filters, a practical approach to combat poverty and inequality
2. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
3. GEN reports on novel tools for deciphering biological networks
4. Animal and biological science highlights: San Antonio Fluid Dynamics Conference, Nov. 23-25
5. Argonne scientists discover possible mechanism for creating handedness in biological molecules
6. Study finds most wars occur in Earths richest biological regions
7. Biological control of tropical weeds using arthropods
8. Musicians have biological advantage in identifying emotion in sound
9. Unclear regulations obstacle to biological diversity
10. New explanation for a puzzling biological divide along the Malay Peninsula
11. CEL-SCI Corporation to Launch Aseptic Filling for Stem Cell Produced Therapies and Other Biological Products
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Why the biological clock? Penn study says aging reduces centromere cohesion, disrupts reproduction
(Date:9/17/2014)... crime unit designed to fight food fraud in ... being passed off as beef scientists from Germany ... describe their approach, which represents a vast improvement over ... Food Chemistry . , Hans-Ulrich Humpf and colleagues note ... But they also say that adding, for example, horse ...
(Date:9/16/2014)... (September 17, 2014)The North American Menopause Society (NAMS) ... comprehensive care of midlife womenon everything from hot ... North American Menopause Society Recommendations for Clinical Care ... the Society,s journal Menopause . This is ... the care of midlife women freely available to ...
(Date:9/16/2014)... same viruses that make us sick can take up ... a sneeze, cough or other troublesome symptom, according to ... St. Louis. , On average, healthy individuals carry ... researchers report online in BioMed Central Biology . ... the diversity of viruses in healthy people. , ...
Breaking Biology News(10 mins):Healthy humans make nice homes for viruses 2Healthy humans make nice homes for viruses 3
... was identified by ancient Egyptians. Genetic analysis done by ... the animal,s range and including DNA from mummified crocodile remains ... name., "This paper provides a remarkable surprise: the Nile crocodile ... demonstrates two species - living side-by side - constitute what ...
... Bone marrow-derived stem cells (BMDCs) have been recognized as ... cell populations in a variety of organs under both normal ... repairing damaged brain tissue or helping to restore lost neural ... cerebellum at the back of the brain. In a recent ...
... Webb from the School of Chemical Engineering and Analytical ... and Excellence Award for Bioprocessing. They received the ... co-production of fuels and chemicals: The biochemical production of ... place last month at the ICC in Birmingham. ...
Cached Biology News:Bone marrow-derived cells differentiate in the brain through mechanisms of plasticity 2Award success for University 2
(Date:9/17/2014)... , Sept. 17, 2014 RXi ... biotechnology company focused on discovering, developing and commercializing ... RNA-targeted technologies, today announced that it has been granted ... Trademark Office on its unique delivery system for ... to phagocytic cells for the treatment of diseases ...
(Date:9/17/2014)... Escape Alert, LLC . filed international patents ... alert owners if their pet has escaped and enable them to ... in the pet’s body. This is the first implantable microchip ... been around for many years, they are passive until read by ... a pet’s location or alert the owner that the pet has ...
(Date:9/17/2014)... The Pistoia Alliance, a global not ... to innovation in life sciences R&D through pre-competitive ... as Executive Director Business Development North America, as ... , Carmen joins the Pistoia Alliance from Accelrys ... Accelrys, she managed various life sciences and material ...
(Date:9/16/2014)... This report analyzes the worldwide markets for Bioinformatics in US$ ... The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... estimates and forecasts are provided for the period 2013 through ... markets. Market data and analytics are derived from primary and ...
Breaking Biology Technology:RXi Pharmaceuticals Strengthens Intellectual Property Portfolio 2RXi Pharmaceuticals Strengthens Intellectual Property Portfolio 3RXi Pharmaceuticals Strengthens Intellectual Property Portfolio 4Implantable Microchip for Pets with GPS Tracking - Patent Filed by Escape Alert, LLC. 2Implantable Microchip for Pets with GPS Tracking - Patent Filed by Escape Alert, LLC. 3Pistoia Alliance Expands Business Development with Appointment of Carmen Nitsche 2Global Bioinformatics Industry 2Global Bioinformatics Industry 3Global Bioinformatics Industry 4Global Bioinformatics Industry 5Global Bioinformatics Industry 6Global Bioinformatics Industry 7Global Bioinformatics Industry 8Global Bioinformatics Industry 9Global Bioinformatics Industry 10Global Bioinformatics Industry 11Global Bioinformatics Industry 12Global Bioinformatics Industry 13Global Bioinformatics Industry 14Global Bioinformatics Industry 15Global Bioinformatics Industry 16Global Bioinformatics Industry 17Global Bioinformatics Industry 18Global Bioinformatics Industry 19Global Bioinformatics Industry 20Global Bioinformatics Industry 21Global Bioinformatics Industry 22Global Bioinformatics Industry 23
... N.J., Aug. 13 Soligenix, Inc. (OTC Bulletin ... press release contains forward-looking statements that reflect Soligenix, ... prospects and opportunities. Statements that are not historical ... expressions, are forward-looking statements. These statements are subject ...
... have fashioned nanowires into a new type of V-shaped transistor ... interior of cells. The new device, described this week ... viruses and about one-hundredth the width of the probes now ... large as the cells themselves. Its slenderness is a marked ...
... of Calgary, Faculty of Medicine scientists who proved it is ... on a silicon chip or the brain on a ... technology that monitors brain cell activity at a resolution never ... Canada (NRC), the new silicon chips are also simpler to ...
Cached Biology Technology:Soligenix Reports Second Quarter 2010 Financial Results and Reviews Accomplishments 2New nanoscale transistors allow sensitive probing inside cells 2Neurochip technology developed by Canadian team 2
Mouse polyclonal antibody raised against a partial recombinant KCTD13. NCBI Entrez Gene ID = 253980...
... direct antibiotic-based selection system for recombinant identification. ... eliminating the need for costly color screening. ... to 100% accuracy in recombinant selection. pLivSelect ... colony picking. This cloning kit is ...
Alpha-2-antiplasmin precursor (Alpha-2-plasmin inhibitor) (Alpha-2-PI) (Alpha-2-AP). [Source:Uniprot/SWISSPROT;Acc:P08697] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Mouse monoclonal antibody raised against a partial recombinant ZNF167. NCBI Entrez Gene ID = ZNF167...
Biology Products: