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Why tackling appetite could hold the key to preventing childhood obesity
Date:2/17/2014

A heartier appetite is linked to more rapid infant growth and to genetic predisposition to obesity, according to two papers published in JAMA Pediatrics today (Monday).

The studies investigated how weight gain is linked to two key aspects of appetite, namely lower satiety responsiveness (a reduced urge to eat in response to internal 'fullness' signals) and higher food responsiveness (an increased urge to eat in response to the sight or smell of nice food).

The first paper reveals that infants with a heartier appetite grew more rapidly up to age 15 months, potentially putting them at increased risk for obesity.

The authors used data from non-identical, same-sex twins born in the UK in 2007. Twin pairs were selected that differed in measures of satiety responsiveness (SR) and food responsiveness (FR) at 3 months, and their growth up to age 15 months was compared. Within pairs, the infant who was more food responsive or less satiety responsive grew faster than their co-twin.

The more food responsive twin was 654g heavier (1.4lbs) than their co-twin at six months and 991g heavier (2.1lbs) at 15 months. The less satiety responsive twin was 637g heavier (1.4lbs) than their co-twin at six months and 918g heavier (2lbs) at 15 months.

"Obesity is a major issue in child health" says Professor Jane Wardle, lead author of the study from the UCL Health Behaviour Research Centre. "Identifying factors that promote or protect against weight gain could help identify targets for obesity intervention and prevention in future. These findings are extremely powerful because we were comparing children of the same age and same sex growing up in the same family in order to reveal the role that appetite plays in infant growth.

"It might make life easy to have a baby with a hearty appetite, but as she grows up, parents may need to be alert for tendencies to be somewhat over-responsive to food cues in the environment, or somewhat unresponsive to fullness.
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Contact: David Weston
d.weston@ucl.ac.uk
44-020-310-83844
University College London
Source:Eurekalert

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