Navigation Links
Why some strains of Lyme disease bacteria are common and others are not
Date:12/3/2012

-footed mice don't get sick when they're infected so the bacteria grow and multiply within them, and when a deer tick bites it sucks up the bacteria along with its blood meal.

In the lab, the group at UC Irvine exposed white-footed mice to various strains of B. burgdorferi and tracked the course of the infection. All the B. burgdorferi strains infected the white-footed mice, but some strains managed to grow to high densities in various mouse tissues while others did not.

Barbour says the immune reactions the mice mounted against the various strains explain these discrepancies: the greater the immune response, the fewer bacteria found in a mouse's tissues and vice-versa. Importantly, the strains that grew to greatest densities within the mice are also the strains that are most prevalent in the wild.

When they looked at the immune reaction to individual B. burgdorferi proteins the authors found a complex interplay of reactivities. The mice reacted in different degrees to the various proteins present in a single bacterial strain, which could explain why such a great diversity of B. burgdorferi strains are sustained in the wild, say the authors.

Barbour says knowing more about how the white-footed mouse reacts to all the various B. burgdorferi strains and immunogenic proteins will help vaccine developers select the best proteins to put in a vaccine. "The best candidate for the mouse vaccine is something that's the same in all the [B. burgdorferi] strains," he says.

Once a vaccine for the white-footed mouse is developed, it will need to be tested by exposing immunized mice to a selected set of diverse B. burgdorferi strains, says Barbour, and the results of this study can help make that selection. "If we can find five that are representative, that would be an advantage."

This study, he says, "is going to provide a foundation for future studies in understanding the
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UCSB researchers find a way to detect stealthy, hypervirulent Salmonella strains
2. Virus barcodes offer rapid detection of mutated strains
3. Made-in-Singapore H5N1 diagnostic kit -- detects all known strains of H5N1 virus with a single test
4. Parkinsons disease stopped in animal model
5. Disease-carrying colonizers on the move: Predicting the spread of ticks across Canada
6. U of Alberta researcher steps closer to understand autoimmune diseases
7. Common North American frog identified as carrier of deadly amphibian disease
8. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
9. Genetic research develops tools for studying diseases, improving regenerative treatment
10. Researchers discover novel therapy for Crohns disease
11. New hope for treating Alzheimers Disease: A role for the FKBP52 protein
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2015)... , July 9, 2015  Synaptics Inc. ... of human interface solutions, today announced a ... first fully hardware encapsulated fingerprint sensor and ... technology is literally off the grid, isolating ... matching within the fingerprint sensor to provide ...
(Date:7/7/2015)... 30, 2015 Research ... addition of the "Capacitive Fingerprint Sensors Patent ... To this date, fingerprint sensing technology is the ... sensors are well developed. This patent landscape focuses ... The domain of capacitive fingerprint sensors is ...
(Date:7/2/2015)... 2015 Fingerprint Cards has received an ... FPC1155 from the distributor World Peace Industrial Group (WPI), part ... Asia . Deliveries are planned to take ... used by smartphone manufacturers in Asia . ... communicated revenue guidance of approximately 2,200 MSEK for 2015. ...
Breaking Biology News(10 mins):Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3Worldwide Capacitive Fingerprint Sensors Patent Landscape Market Report 2015-2020 - Main IP Holders include Seiko Epson, AuthenTec, Sony and STMicroelectronics 2FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2
... Ten weeks of preventive supplementation with a natural form ... strokes reduced overall brain tissue damage, prevented loss of neural ... a new study shows. Researchers say the findings suggest ... vitamin E could be particularly helpful to people considered at ...
... A new study finds high folate intake is ... finding consistent with the findings of most previous epidemiologic ... has suggested that consumption of very high levels of ... risk of some cancers. Nonetheless, the potential importance of ...
... University of Georgia researcher has invented a new ... clothing, face masks, paper towelsand yes, even diapers, ... germ-free. The simple and inexpensive anti-microbial technology ... can be applied during the manufacturing process or ...
Cached Biology News:Study: Preventive use of one form of natural vitamin E may reduce stroke damage 2Study: Preventive use of one form of natural vitamin E may reduce stroke damage 3Study: Preventive use of one form of natural vitamin E may reduce stroke damage 4Folate intake may reduce colorectal cancer risk 2New UGA technology makes textiles permanently germ-free; targets health care-associated infections 2New UGA technology makes textiles permanently germ-free; targets health care-associated infections 3
(Date:7/31/2015)... , July 31, 2015 China Cord ... China,s leading provider of cord blood ... cell storage services, today announced that the Company has ... U.S. Securities and Exchange Commission. The filed Form 20-F ... March 31, 2015. The Form 20-F can be accessed ...
(Date:7/30/2015)... ... July 30, 2015 , ... Tronics, ... as Sales & Marketing Director. , With more than 25 years of ... for reinforcing Tronics’ business development activities worldwide. He brings to the company his ...
(Date:7/30/2015)... DIEGO, July 30, 2015   Senomyx , Inc. ... taste science technologies to discover, develop, and commercialize novel ... industries, today reported financial results for the second quarter ... of 2015, we remain on track to achieve our ... Chief Executive Officer of the Company. "Since our last ...
(Date:7/30/2015)... ... July 30, 2015 , ... As part of its 2015 growth plan and as ... technical service business units, Whitehouse Laboratories is pleased to announce that it has ... the Container Center of Excellence and will be strictly dedicated to basic USP 51, USP ...
Breaking Biology Technology:China Cord Blood Corporation Files Its Annual Report on Form 20-F 2Tronics appoints Francois Vieillard as Sales and Marketing Director 2SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 2SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 3SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 4SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 5SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 6SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 7SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 8SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 9Whitehouse Labs Formally Announces Plans to Open a Microbiological Laboratory 2
... sustainable biofuels on commercial flights will be top of the agenda ... Geneva, Switzerland. The global Summit will also highlight the technological progress, ... the international aviation industry,s response to climate change. , ... ...
... are developing a technique for mass producing computer chips ... Experts believe that graphene -- the sheet-like form of ... to smaller, faster electronics. It might also deliver quantum ... , Until now, most researchers could only create tiny ...
... its recent analysis of the elastic nonwovens market, Frost & ... Frost & Sullivan Technology Leadership of the Year Award for ... styrenic block copolymers (SBCs). Already established as an innovator in ... of SBCs, the MD6705, G1643, and MD6717 grades are in ...
Cached Biology Technology:Global Aviation Summit Explores Low-Carbon Flight 2Researchers find better way to manufacture fast computer chips 2Researchers find better way to manufacture fast computer chips 3Frost & Sullivan Recognizes Kraton Polymers for Developing a New Generation of Polymer Grades Suitable for High-Speed Processing in Nonwoven Manufacture 2Frost & Sullivan Recognizes Kraton Polymers for Developing a New Generation of Polymer Grades Suitable for High-Speed Processing in Nonwoven Manufacture 3Frost & Sullivan Recognizes Kraton Polymers for Developing a New Generation of Polymer Grades Suitable for High-Speed Processing in Nonwoven Manufacture 4Frost & Sullivan Recognizes Kraton Polymers for Developing a New Generation of Polymer Grades Suitable for High-Speed Processing in Nonwoven Manufacture 5
... consists of two components used for alkaline ... ES cell-specific antibodies required to perform 100 ... become the subject of extensive investigation recently, ... because they raise several fundamental issues concerning ...
Application: For use as a carrier in nucleic acid purification and precipitation. Physical form: Solution in 10 mM Tris HCl, pH 7.4, 1 mM EDTA Concentration: 9-11 mg/mL Physical Form: buffered aqu...
... For use as a carrier ... precipitation. Physical form: Solution in ... 7.4, 1 mM EDTA Preparation ... Concentration: 10 ...
... Dithiothreitol DTT White solid.. PACKAGED UNDER ... thiols, so reaction is "driven" to completion. A ... waxy surfactant found in many other preparations. Blocks ... Purity: ≥97% by titration. Contaminants: Heavy ...
Biology Products: