Navigation Links
Why some strains of Lyme disease bacteria are common and others are not
Date:12/3/2012

-footed mice don't get sick when they're infected so the bacteria grow and multiply within them, and when a deer tick bites it sucks up the bacteria along with its blood meal.

In the lab, the group at UC Irvine exposed white-footed mice to various strains of B. burgdorferi and tracked the course of the infection. All the B. burgdorferi strains infected the white-footed mice, but some strains managed to grow to high densities in various mouse tissues while others did not.

Barbour says the immune reactions the mice mounted against the various strains explain these discrepancies: the greater the immune response, the fewer bacteria found in a mouse's tissues and vice-versa. Importantly, the strains that grew to greatest densities within the mice are also the strains that are most prevalent in the wild.

When they looked at the immune reaction to individual B. burgdorferi proteins the authors found a complex interplay of reactivities. The mice reacted in different degrees to the various proteins present in a single bacterial strain, which could explain why such a great diversity of B. burgdorferi strains are sustained in the wild, say the authors.

Barbour says knowing more about how the white-footed mouse reacts to all the various B. burgdorferi strains and immunogenic proteins will help vaccine developers select the best proteins to put in a vaccine. "The best candidate for the mouse vaccine is something that's the same in all the [B. burgdorferi] strains," he says.

Once a vaccine for the white-footed mouse is developed, it will need to be tested by exposing immunized mice to a selected set of diverse B. burgdorferi strains, says Barbour, and the results of this study can help make that selection. "If we can find five that are representative, that would be an advantage."

This study, he says, "is going to provide a foundation for future studies in understanding the
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UCSB researchers find a way to detect stealthy, hypervirulent Salmonella strains
2. Virus barcodes offer rapid detection of mutated strains
3. Made-in-Singapore H5N1 diagnostic kit -- detects all known strains of H5N1 virus with a single test
4. Parkinsons disease stopped in animal model
5. Disease-carrying colonizers on the move: Predicting the spread of ticks across Canada
6. U of Alberta researcher steps closer to understand autoimmune diseases
7. Common North American frog identified as carrier of deadly amphibian disease
8. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
9. Genetic research develops tools for studying diseases, improving regenerative treatment
10. Researchers discover novel therapy for Crohns disease
11. New hope for treating Alzheimers Disease: A role for the FKBP52 protein
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/17/2015)... , Aug. 17, 2015  NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market and ... sales campaign for Q4 2015. The new marketing campaign ... consisting of Amplitude Marketing Group ( http://amplitudemarketing.com/ ) and ... is a leader in retail driven marketing and brand ...
(Date:8/12/2015)... , Aug. 12, 2015  New research ... can attack Android phones to steal users, fingerprints. ... increasing availability of fingerprint scanners on mobile devices, ... concern. To secure biometrics on mobile devices, HYPR ... augment these convenient authentication systems with strong cryptographic ...
(Date:8/10/2015)... Germany , August 10, 2015 ... leader in Eye Tracking Technology for more than two ... Tracking Platform for integration into all consumer display formats. ... for seamless integration of eye tracking into consumer tablets, ... augmented reality smart glasses. Omnivision,s leading sensor technology contributes ...
Breaking Biology News(10 mins):NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 3SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 3
... scans to measure blood flow in the lungs of people ... are most at risk of emphysema before the disease damages ... University of Iowa study. The study found that smokers ... normal lung function, have very different blood flow patterns in ...
... Chronix Biomedical today announced publication of a study ... tests to predict clinical status and monitor disease activity ... Chronix Biomedical uses proprietary technology to identify disease-specific genetic ... into the bloodstream by damaged and dying cells. ...
... 2010) -- A scientist at Barrow Neurological Institute in Phoenix ... Association (MDA) to continue his groundbreaking work in the disease ... part of MDA,s ongoing commitment to fund neuromuscular research that ... and related diseases. Including this funding, the MDA has ...
Cached Biology News:New test could identify smokers at risk of emphysema 2Chronix Biomedical's serum DNA assays monitor disease activity and treatment response in MS 2Chronix Biomedical's serum DNA assays monitor disease activity and treatment response in MS 3Barrow scientist receives $450K MDA grant 2
(Date:9/2/2015)... September 2, 2015 BioLight ... or the "Company"), a firm that invests in, ... cancer diagnostics, announced today that presentations highlighting its ... be delivered at the Ophthalmology Futures European Forum ... of Cataract & Refractive Surgeons ("ESCRS"), both taking ...
(Date:9/2/2015)... Biovista Inc. freut sich, ... 2015 bekanntgeben zu können. Hierbei handelt es sich ... Biovista unterstützt mit seiner Möglichkeit der Analyse ... Krankheiten als denen, für die ein Medikament ursprünglich ... Team bei der Wylder Nation Foundation bei der ...
(Date:9/2/2015)... ... 2015 , ... Whitehouse Laboratories is excited to announce that ... upcoming educational seminar and training session on Extractable & Leachable testing. Featuring a ... Updates & Case Studies on the Latest Compliance Implications of USP and ICH ...
(Date:9/2/2015)... ... September 02, 2015 , ... The ... creating professional commercial video content, to analysis of athletic performance. Producing high-resolution ... go by too quickly to process with the naked eye. , Slow ...
Breaking Biology Technology:Presentations to Highlight BioLight's IOPtiMate[TM] System at Upcoming European Ophthalmology Conferences 2Presentations to Highlight BioLight's IOPtiMate[TM] System at Upcoming European Ophthalmology Conferences 3Biovista sponsert die Forschung von Wylder Nation Foundation zum Thema Mangel an saurer Sphingomyelinase 2Whitehouse Laboratories to Participate in Pharm Ed Resources Extractables, Leachables, & Elemental Impurities Educational Seminar 2Whitehouse Laboratories to Participate in Pharm Ed Resources Extractables, Leachables, & Elemental Impurities Educational Seminar 3Fastec Introduces the Quad-HD TS5-Q High-Speed Camera 2Fastec Introduces the Quad-HD TS5-Q High-Speed Camera 3
... , , RESEARCH TRIANGLE PARK, ... today announced that it has completed its acquisition of Stiefel Laboratories, Inc. ... cash consideration of $2.9 billion. GSK also assumed $0.4 billion of ... obligated to make additional cash payments of up to $0.3 billion depending ...
... , DUBAI, United Arab Emirates and SAN ... and medical device company serving the Middle East, Africa, Turkey ... an exclusive license and supply agreement with Axcan Pharma for ... eradication of Helicobacter pylori , a bacterium now recognized ...
... , , CHICAGO, July ... Chemistry (AACC) annual meeting today indicates that monitoring cardiac transplant ... analyzer may help clinicians to monitor cyclosporine-induced toxicity and adjust ... , , In ...
Cached Biology Technology:GlaxoSmithKline Completes Acquisition of Stiefel 2NewBridge Pharmaceuticals Announces Licensing of Pylera(R) for Middle East, Africa, Turkey & Caspian Region 2NewBridge Pharmaceuticals Announces Licensing of Pylera(R) for Middle East, Africa, Turkey & Caspian Region 3Investigational Urine NGAL Biomarker Shows Promise to Monitor Cyclosporine Toxicity in Cardiac Transplant Patients 2
Eagle's Ham's amino acids; EHAA...
... provides quick and easy operation of a ... control. The software is fully secure ... CFR Part 11 regulations, and compatible with ... IRsolutions versatility enables use in high-level research ...
... random mutations to the gene supplied by a ... a vector of choice to obtain a library ... be set to a desired value within 1-20 ... Mutations can be restricted to a desired ...
... Tecans new Enzyme-Linked Immunosorbent Assay (ELISA) analyzer ... is a dedicated EVO platform for reliableELISA ... and incubation units operated by the new ... available in three sizes - 100, 150, ...
Biology Products: