Navigation Links
Why some primates, but not humans, can live with immunodeficiency viruses and not progress to AIDS
Date:9/16/2008

o not develop AIDS despite high levels of ongoing SIV replication. Our studies sought to understand the basis for the very different responses to AIDS virus infections in different species," says Mark Feinberg, MD, PhD, the paper's senior author. Feinberg is a former investigator at the Emory Vaccine Center and the Yerkes Research Center and a professor of medicine at the Emory University School of Medicine. He currently serves as vice president of medical affairs and policy for vaccines and infectious diseases at Merck & Co., Inc.

The reasons are found in significant differences in immune signaling in a specific type of dendritic cells in AIDS-susceptible or resistant host species. Dendritic cells are part of the immune system that play a key role in alerting the body to the presence of invading viruses or bacteria, and in initiating immune responses that enable clearance of these infections. They detect the invaders using molecules called Toll-like receptors.

Feinberg's team found that in sooty mangabeys, dendritic cells produce much less interferon alpha--an alarm signal to the rest of the immune system--in response to SIV. As a result, the dendritic cells are not activated during the initial or chronic stages of SIV infection, and mangabeys fail to mount a significant immune response to the virus. In contrast to mangabeys, dendritic cells from humans and macaques that are susceptible to developing AIDS are readily activated by HIV and SIV.

The difference in whether or not dendritic cells become activated upon AIDS virus exposure in specific primate hosts appears to result from species-specific differences in patterns of Toll-like-receptor signaling. Because host immune responses are unable to clear AIDS virus infections, ongoing virus replication leads to unrelenting activation of the immune system in humans and macaques.

Unfortunately, rather than promoting clearance of the infection, chronic dendritic cell stimulation may
'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Like humans, monkey see, monkey plan, monkey do
2. Features of replication suggest viruses have common themes, vulnerabilities
3. Gamma globulin effective in treating eye infections caused by adenoviruses
4. Discovery may help defang viruses
5. Prions and retroviruses -- an unholy alliance?
6. Study proposes new theory of how viruses may contribute to cancer
7. Iowa State researchers develop technology for early detection of viruses
8. Yellowstone viruses jump between hot pools
9. Great apes endangered by human viruses
10. The Uukuniemi virus helps to explain the infection mechanism of bunyaviruses
11. Viruses evolve to play by host rules, according to University of Pennsylvania researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... available in Spanish . ... study published in the Journal of Cell Biology ... for proper cell division , At this very moment thousands ... the mechanism by which the body repairs damaged tissues and ... complex process known as "mitosis", during which the cell duplicates ...
(Date:9/16/2014)... PALM BEACH GARDENS, Fla. , Sept. 16, ... provider of biometric identity management solutions, announced today ... handheld solution designed to authenticate the identity of ... The Android-based Verifier Sentry rapidly reads ... the credential holder,s ID by matching the biometric ...
(Date:9/15/2014)... populations may continue to drop in French Guiana, despite ... National de la Chasse et de la Faune Sauvage ... data retrieved from camera traps in the Nouragues National ... data to current harvest rates in the region., "In ... Guiana," said Matthias Tobler, a scientist with the San ...
Breaking Biology News(10 mins):Unraveling cell division 2Unraveling cell division 3Cross Match Launches New Identity Management Handheld Solution 2
... A new book featuring a series of interviews ... available from the Inter-American Network of Academies of Sciences ... highlights the inclusion and empowerment of women in science ... Juan Pedro Laclette say in the book,s introduction that ...
... March 8, 2013 Dr. Eric Olson , chairman ... 2013 recipient of the March of Dimes Prize in Developmental ... the heart and other muscles. His work is credited ... could lead to novel treatments for heart disease and muscle ...
... a new method for attaching proteins to the surface ... membrane proteins. This enables time-resolved tracking of the interactions ... is accurate down to atomic resolution. The method is ... K4DD", in which scientists explore the interplay of drugs ...
Cached Biology News:New book celebrates women scientists in the Americas 2UTSW molecular biologist Olson wins March of Dimes developmental biology prize 2Specialised germanium surface as universal protein adapter 2Specialised germanium surface as universal protein adapter 3
(Date:9/15/2014)... The very idea of fibers made of carbon nanotubes is ... literally. , The single-walled carbon nanotubes in new fibers created ... through a process designed by chemist Angel Mart and his ... reported its results this month in the journal ACS ... they,re drawn together into a fiber. , Left to their ...
(Date:9/15/2014)... MORRISVILLE, NC (PRWEB) September 15, 2014 ... newly developed deep imaging OCT system for the optical ... , The EnvisuTM S4410 SDOCT for Contact ... measurements for standard and high complexity contact lens, IOL ... allows imaging of a complete contact lens immersed in ...
(Date:9/15/2014)... BOISE, Idaho , Sept. 15, 2014  iVinci ... and only comprehensive Patient Revenue Management system, branded as ... The company also announced the launch of a new ... Portal that provides an easy and convenient way for ... plans for balances owed by them and their families. ...
(Date:9/15/2014)... The chemistry, taste, and health effects of tea can vary ... the nonprofit American Botanical Council (ABC). Recent research by ... on the phytochemical compounds in tea ( Camellia sinensis ) ... in the Yunnan province of southwestern ... future of medicinal botanicals. Dr. Ahmed,s report on ...
Breaking Biology Technology:Rice rolls 'neat' nanotube fibers 2Rice rolls 'neat' nanotube fibers 3Bioptigen Introduces Deep Imaging OCT System for Contact Lens Metrology 2iVinci Health Raises $5M to Fuel National Expansion, Announces Launch of Personal Finance Portal for Healthcare 2iVinci Health Raises $5M to Fuel National Expansion, Announces Launch of Personal Finance Portal for Healthcare 3Tea Taste and Quality Affected by Climate Change 2Tea Taste and Quality Affected by Climate Change 3Tea Taste and Quality Affected by Climate Change 4
... Switzerland, Jan. 5, 2012   Selexis SA ... Ph.D., will present at the Biotech Showcase 2012 Conference ... Conference in San Francisco, CA. Dr. Fisch ... Growth Investment" to prospective investors and corporate partners on ...
... Calif., Jan. 5, 2012  AtheroNova, (OTCQB: AHRO) ("AtheroNova"), a biotech ... regress atherosclerotic plaque, announced today that it has appointed Johan ... of Directors of the Company effective January 3, 2012. Mr. ... Audit and Medical Committees of the Board. ...
... 2012 CMC Biologics, a leading biopharmaceutical contract ... No. US 2,171,034 B1 covering a method for ... culture bioreactors. The invention is designed to optimize ... fermentation process, wherein the bioreactor (fermenter) has an ...
Cached Biology Technology:Selexis SA to Present at Biotech Showcase 2012 2AtheroNova Announces a New Board Member 2AtheroNova Announces a New Board Member 3CMC Biologics Strengthens its Innovative Biomanufacturing Technology Portfolio in Continuous Perfusion Systems 2
Request Info...
Kit containing positive control DNA all parts of the HIV-1 genome, HIV-1 negative control DNA, Primers SK38, SK39, SK19...
Contains 0.2 g/L EDTA4Na in phosphate-buffered saline....
Immunochemistry 1 & 2...
Biology Products: