Navigation Links
Why some primates, but not humans, can live with immunodeficiency viruses and not progress to AIDS
Date:9/16/2008

Key differences in immune system signaling and the production of specific immune regulatory molecules may explain why some primates are able to live with an immunodeficiency virus infection without progressing to AIDS-like illness, unlike other primate species, including rhesus macaques and humans, that succumb to disease.

Following the identification of HIV (Human Immunodeficiency Virus) as the cause of AIDS 25 years ago, an extensive search was undertaken to identify the source of the virus. These studies led to the discovery that chimpanzees and sooty mangabeys are infected in the wild with simian immunodeficiency viruses (SIV), whose transmission to humans and macaques leads to AIDS.

Surprisingly, the natural hosts for the AIDS viruses, such as the mangabeys and numerous other African primate species who have been found to harbor SIVs in the wild, remain healthy despite infection. Understanding how the natural hosts evolved to resist the development of immunodeficiency disease has long represented a key unsolved mystery in our understanding of AIDS. Furthermore, definition of the mechanisms by which they resist disease could help explain the mechanisms underlying AIDS progression in humans.

A team of scientists from Yerkes National Primate Research Center and the Emory Vaccine Center has discovered that the immune systems of sooty mangabeys are activated to a significantly lower extent during SIV infection than are the immune systems of rhesus macaques, and that this difference may explain why SIV and HIV infection leads to AIDS in some primate species but not others.

"During both HIV infection in humans and SIV infection in macaques, the host immune system becomes highly activated, experiences increased destruction and decreased production of key immune effector cells and progressively fails as a result. In contrast, natural hosts for SIV infection, like sooty mangabeys, do not exhibit aberrant immune activation and d
'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Like humans, monkey see, monkey plan, monkey do
2. Features of replication suggest viruses have common themes, vulnerabilities
3. Gamma globulin effective in treating eye infections caused by adenoviruses
4. Discovery may help defang viruses
5. Prions and retroviruses -- an unholy alliance?
6. Study proposes new theory of how viruses may contribute to cancer
7. Iowa State researchers develop technology for early detection of viruses
8. Yellowstone viruses jump between hot pools
9. Great apes endangered by human viruses
10. The Uukuniemi virus helps to explain the infection mechanism of bunyaviruses
11. Viruses evolve to play by host rules, according to University of Pennsylvania researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... Minn. A Mayo Clinic researcher and his collaborators ... up and enhance the process of re-engineering cells for ... uses network biology methods to aid stem cell engineering. ... engineering are described in two back-to-back papers in the ... a broad range of uses for all types of ...
(Date:8/28/2014)... 28, 2014  Privacy Advocate and Senior Staff Attorney ... , joins the lineup of biometric and mobile commerce ... UnPlugged Executive Summit in Tampa, Florida ... announced speakers include Steven Rahman, Director, Technology and Strategy at ... Experian. The theme of this year,s event is Mobility ...
(Date:8/28/2014)... the most commonly diagnosed learning disability in the ... occurs when the regions of the brain that ... use of non-invasive functional neuroimaging tools has helped ... However, most prior work has focused on only ... gap in our understanding of how multiple brain ...
Breaking Biology News(10 mins):New tool aids stem cell engineering for medical research 2Biometrics UnPlugged Welcomes the Electronic Frontier Foundation's Jennifer Lynch to the Mobility at the Crossroads of Commerce and Privacy Summit 2Dyslexic readers have disrupted network connections in the brain 2
... OTTAWA November 14, 2010 One of the largest, ... University of Ottawa Heart Institute (UOHI), conclusively proves that a ... while reducing risk of death by 24% compared to the ... and Dr. George Wells at the Heart Institute, brings the ...
... Kritzer, assistant professor in the School of Arts and ... awarded one of 33 NIH Director,s New Innovator Awards, ... National Institutes of Health. The NIH Director,s New ... creative new investigators with highly innovative research ideas at ...
... the association for informatics professionals, honors four leaders ... 2010, with the annual presentation of its Signature ... Monday, Nov. 15 at the Opening Session of ... Informatics in Washington, D.C., before an audience of ...
Cached Biology News:Synchronizing a failing heart 2Tufts University chemist earns prestigious award for promising research on drug development 2Recognition given for ground-breaking advancements in digitalizing health data and information 2Recognition given for ground-breaking advancements in digitalizing health data and information 3Recognition given for ground-breaking advancements in digitalizing health data and information 4
(Date:8/27/2014)... BOSTON , Aug. 27, 2014 Rhythm, ... diseases and genetic deficiencies that result in metabolic disorders, ... on Form S-1 with the U.S. Securities and Exchange ... of shares of its common stock. The number of ... the offering have not yet been determined. ...
(Date:8/27/2014)... YORK , Aug. 27, 2014 /PRNewswire/ ... research report is available in its catalogue: ... 2014-2018 http://www.reportlinker.com/p02316661/Global-Biodegradable-Packaging-Materials-Market-2014-2018.html ... materials are materials that are readily decomposed ... differs from conventional non-degradable packaging in terms ...
(Date:8/27/2014)... is how plants survive impact by the huge ... while using this energy for photosynthesis. The hypothesis ... blades quickly dissipate the energy throughout the entire ... DTU Physics have now managed to successfully ,film, ... contain light-absorbing proteins which play a role in ...
(Date:8/27/2014)... Aug. 27, 2014 Reportlinker.com announces that ... its catalogue: Global Chelating Agents Market ... About Chelating Agent A chelating agent is ... with metal ions, thereby forming a metal-ion complex. ... have on chemical processes, formulations, and the environment ...
Breaking Biology Technology:Rhythm Files Registration Statement for Proposed Initial Public Offering 2Global Biodegradable Packaging Materials Market 2014-2018 2Global Biodegradable Packaging Materials Market 2014-2018 3Global Biodegradable Packaging Materials Market 2014-2018 4Global Biodegradable Packaging Materials Market 2014-2018 5Global Biodegradable Packaging Materials Market 2014-2018 6Global Biodegradable Packaging Materials Market 2014-2018 7DTU researchers film protein quake for the first time 2Global Chelating Agents Market 2014-2018 2Global Chelating Agents Market 2014-2018 3Global Chelating Agents Market 2014-2018 4
... ... ... ... ...
... ... Evonik for Industrial Biotechnology R&D Processes , ... Basel, Switzerland (PRWEB) February 23, 2010 -- ... announced an extended partnership with Evonik, a leading life science, specialty chemicals and ...
... Medicine , Susan Huang and colleagues describe the use ... by integrating two freely available software packages, to identify ... data from patients admitted to a 750-bed academic medical ... authors found that the tool identified a number of ...
Cached Biology Technology:Barnes-Jewish Hospital to Provide Gamma Knife Surgery to Additional Patient Groups With New Elekta Technology 2Barnes-Jewish Hospital to Provide Gamma Knife Surgery to Additional Patient Groups With New Elekta Technology 3Barnes-Jewish Hospital to Provide Gamma Knife Surgery to Additional Patient Groups With New Elekta Technology 4Barnes-Jewish Hospital to Provide Gamma Knife Surgery to Additional Patient Groups With New Elekta Technology 5Barnes-Jewish Hospital to Provide Gamma Knife Surgery to Additional Patient Groups With New Elekta Technology 6Evonik Extends Long-term Research & Development Partnership with Genedata 2Evonik Extends Long-term Research & Development Partnership with Genedata 3Evonik Extends Long-term Research & Development Partnership with Genedata 4Tool identifies infection clusters; rate of T cell drop not helpful in decision to start treating HIV 2Tool identifies infection clusters; rate of T cell drop not helpful in decision to start treating HIV 3Tool identifies infection clusters; rate of T cell drop not helpful in decision to start treating HIV 4
... The MONOLIGHT 3096 Microplate Luminometer has ... and bioluminescence and for,all measurements of ... for reactions where the light remain ... time, as well as for very ...
... Get results sooner and save hours of valuable ... the need for a membrane transfer step and ... ready-to-use. No reagents to prepare or mix or ... Guarantees a simple to perform, mistake-free detection protocol. ...
... The EZ-Tn5™ Plasmid-Based Deletion Machine is based ... transposition system developed by Goryshin and Reznikoff, ... of nested families of deletions and inversions ... in a transposon-containing plasmid vector. Although most ...
... is designed to knockout or alter genes on ... one week. Red/ET recombination allows the exchange of ... and faithful manner. An FRT-flanked kanamycin resistance marker ... be used to replace a gene on the ...
Biology Products: