Navigation Links
Why patients with epidermolysis bullosa suffer extreme pain
Date:7/8/2011

the cell in a controlled manner. Upon touch, pressure on the extracellular matrix actuates a tether mechanism on the ion channels, thus opening the channels and allowing the charged particles to flow through. This excites the neuron, thus enabling the stimulus to be perceived.

Unsuppressed mechanotransduction

In experiments using cell cultures, the MDC researchers found that physical stimuli trigger ion currents in all neurons not surrounded by laminin-332. In neurons growing on laminin-332, by contrast, the number of responsive cells was much reduced. "To a great extent, laminin-332 blocks the tether mechanism that opens the ion channels, thus impeding stimulus transduction. Because patients with epidermolysis bullosa are deficient in laminin-332, the transduction of the stimulus is unsuppressed. Their sensory neurons are excited much more strongly, and thus they react much more sensitively to mechanical stimuli," Professor Lewin explained.

Furthermore, in the skin tissue of EB patients the MDC researchers found that sensory neurons showed much more branching than in the skin of healthy individuals. "From cell-culture experiments we know that laminin-332 inhibits neuronal branching. Without laminin-332 this inhibition does not take place. Presumably, this effect also contributes to the increased perception of tactile stimuli," Professor Lewin said.

In further studies the researchers hope to find drug targets for therapy. However, much has already been achieved: "Because the causal mechanisms are now understood, we can focus on the patient's pain situation and on administering more efficient pain therapies," he added. "We recommend that in treating the disease, neurologists should be consulted in addition to dermatologists.


'/>"/>

Contact: bachtler@mdc-berlin.de
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. For insulin sensitive overweight patients, 1 session of exercise improves metabolic health
2. UCR researchers propose minocycline as a promising drug for patients with Fragile X syndrome
3. Text focuses on diagnosing infections in immunocompromised patients
4. UCSF Fresno leading-edge study lends hope to emphysema patients
5. How eating fruit and vegetables can improve cancer patients response to chemotherapy
6. New test promises quicker, more accurate evaluation for cystic fibrosis patients
7. Phase III data show efficacy/safety of iclaprim in patients with complicated skin infections
8. Geisinger research: Antimalarial drug prevents diabetes in arthritis patients
9. Mitochondria could be a target for therapeutic strategy for Alzheimers disease patients
10. Stroke patients soon may have fun, high-tech tool
11. Drops in blood oxygen levels may be key to sudden death in some epilepsy patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... foliage season that prompts millions of Americans to undertake jaunts ... possibly last a little longer within a century, according to ... in some areas of the United States as summer temperatures ... the journal Global Ecology and Biogeography . For instance, ... the state tree of New Hampshire could change color ...
(Date:9/18/2014)... tiny strands of nucleic acid that contain instructions for ... data, our DNA is copied into RNA molecules, which ... in our cells. , Several years ago, scientists ... other known RNAs, this molecule is circular, and was ... has been known about how they are produced. Moreover, ...
(Date:9/18/2014)... 2014 -- Arizona turned its newborn screening program into a ... months, earning it the first-ever Newborn Screening Quality Award from ... presented Will Humble, M.P.H., Arizona,s Department of Health Services director, ... Humble established a policy of full transparency for the length ... samples to the lab for analysis, and set a target ...
Breaking Biology News(10 mins):Fall foliage season may be later, but longer on warmer Earth 2Fall foliage season may be later, but longer on warmer Earth 3Fall foliage season may be later, but longer on warmer Earth 4Scientists find how mysterious 'circular RNA' is formed, claim muscular dystrophy link 2March of Dimes honors Arizona with first-ever newborn screening award 2March of Dimes honors Arizona with first-ever newborn screening award 3
... long thought to have fully recovered from whaling, were once ... according to a report to be published September 10 in ... Todays population of more than 22,000 gray whales has successfully ... now the most abundant whale on the North American west ...
... consultant to UNESCO and a former Administrator of the National ... Stevens Institute of Technology, Sept. 26, titled, Global Warming and ... The talk will be delivered at Stevens Babbio Center for ... Babbio Center is located on the Stevens campus in Hoboken, ...
... of Energy,s Brookhaven National Laboratory have developed new ways ... oxide, a material used in a variety of industrial ... materials may lead to improved catalysts for hydrogen production, ... research is published in two papers now available online, ...
Cached Biology News:Gray whales a fraction of historic levels, genetic research says 2Global Warming and the Habitability of Planet Earth, Sept. 26 2Tiny tubes and rods show promise as catalysts, sunscreen 2
(Date:9/19/2014)... ROCKLAND, Massachusetts , September 19, 2014 ... with the 53rd European Society for Paediatric Endocrinology (ESPE) ... advancement of science and medical research in the field ... of Merck KGaA, Darmstadt, Germany , ... Growth Innovation (GGI) for 2014. The awards were announced ...
(Date:9/18/2014)... HealthTronics, Inc ., a ... products and services, announced that a poster related ... versus external beam radiotherapy (EBRT) is being presented ... Association (MAAUA) Annual Meeting in Baltimore, Maryland September ... Cryosurgery and External Beam Radiation as Treatments for ...
(Date:9/18/2014)... Mass. (PRWEB) September 18, 2014 A ... of an MRI scanner is currently being tested as ... and Women's Hospital in Boston with the aim of ... images, can make prostate cancer biopsies faster, more accurate, ... novel system also has the potential to deliver prostate ...
(Date:9/18/2014)... Bryan-College Station, Texas (PRWEB) September 18, 2014 ... University System Chancellor John Sharp, Texas A&M Health ... from the U.S. Department of Health and Human ... GSK today dedicated a national pandemic influenza vaccine ... will serve as an anchor for the Texas ...
Breaking Biology Technology:EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 2EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 3HealthTronics Announces Data Comparing Cryotherapy Versus Radiation for Treating Prostate Cancer Poster Presented at the American Urological Association Regional Meeting 2Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 2Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 3Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 4Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 5Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 6Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 2Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 3Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 4
... the Hyatt Regency Cambridge, ... Massachusetts, ... leading marketplace for expertise, and the Biotechnology Industry,Organization (BIO) announced an ... venture investment community,registered to attend the BIO National Venture Conference, with ...
... Executive Positions, WITTEN, Germany, April 8 Sangui ... its,fiscal year ended June 30, 2006, on April 3, ... with the SEC the company almost tripled its sales,of ... level. In,FY 2006, Sangui yielded sales of approximately USD ...
... DUBLIN, Calif., April 8, 2008 Microchip,Biotechnologies, Inc. ... Centre,for DNA Barcoding (CCDB), at the Biodiversity Institute ... participant to join MBI,s early,access program for the ... is the,first fully automated and integrated system for ...
Cached Biology Technology:Gerson Lehrman Group Extends Partnership With BIO to Provide Scientific Expertise for the First Annual BIO National Venture Conference 2Gerson Lehrman Group Extends Partnership With BIO to Provide Scientific Expertise for the First Annual BIO National Venture Conference 3Sangui BioTech International, Inc., Reports Sales Increase, Continued Losses 2Sangui BioTech International, Inc., Reports Sales Increase, Continued Losses 3Canadian Centre for DNA Barcoding to Participate in Microchip Biotechnologies Early Access Program for Microchip-Based DNA Sample Preparation and Cycle Sequencing 2
Recombinant Mouse TGF-beta RII/(human) Fc Chimera, CF...
Recombinant Mouse Noggin...
... Antibody Sampler Kit Kit Includes: ... 40 ul Histone Deacetylase 3 (HDAC3) Antibody, ... (HDAC4) Antibody, Catalog #2072, 40 ul Histone ... ul Histone Deacetylase 6 (HDAC6) Antibody, Catalog ...
An instrument that delivers an accurate and uniform amount of light energy to cells to photoactivate csiRNA products....
Biology Products: