Navigation Links
Why patients with epidermolysis bullosa suffer extreme pain
Date:7/8/2011

the cell in a controlled manner. Upon touch, pressure on the extracellular matrix actuates a tether mechanism on the ion channels, thus opening the channels and allowing the charged particles to flow through. This excites the neuron, thus enabling the stimulus to be perceived.

Unsuppressed mechanotransduction

In experiments using cell cultures, the MDC researchers found that physical stimuli trigger ion currents in all neurons not surrounded by laminin-332. In neurons growing on laminin-332, by contrast, the number of responsive cells was much reduced. "To a great extent, laminin-332 blocks the tether mechanism that opens the ion channels, thus impeding stimulus transduction. Because patients with epidermolysis bullosa are deficient in laminin-332, the transduction of the stimulus is unsuppressed. Their sensory neurons are excited much more strongly, and thus they react much more sensitively to mechanical stimuli," Professor Lewin explained.

Furthermore, in the skin tissue of EB patients the MDC researchers found that sensory neurons showed much more branching than in the skin of healthy individuals. "From cell-culture experiments we know that laminin-332 inhibits neuronal branching. Without laminin-332 this inhibition does not take place. Presumably, this effect also contributes to the increased perception of tactile stimuli," Professor Lewin said.

In further studies the researchers hope to find drug targets for therapy. However, much has already been achieved: "Because the causal mechanisms are now understood, we can focus on the patient's pain situation and on administering more efficient pain therapies," he added. "We recommend that in treating the disease, neurologists should be consulted in addition to dermatologists.


'/>"/>

Contact: bachtler@mdc-berlin.de
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. For insulin sensitive overweight patients, 1 session of exercise improves metabolic health
2. UCR researchers propose minocycline as a promising drug for patients with Fragile X syndrome
3. Text focuses on diagnosing infections in immunocompromised patients
4. UCSF Fresno leading-edge study lends hope to emphysema patients
5. How eating fruit and vegetables can improve cancer patients response to chemotherapy
6. New test promises quicker, more accurate evaluation for cystic fibrosis patients
7. Phase III data show efficacy/safety of iclaprim in patients with complicated skin infections
8. Geisinger research: Antimalarial drug prevents diabetes in arthritis patients
9. Mitochondria could be a target for therapeutic strategy for Alzheimers disease patients
10. Stroke patients soon may have fun, high-tech tool
11. Drops in blood oxygen levels may be key to sudden death in some epilepsy patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... , Dec. 9, 2014  Valencell, a leader in ... seeing a staggering demand from its licensees for highly ... revealed, is not solely coming from fitness and health ... "A wearable is only as useful as ... is the ultimate driver in long-term mass consumer adoption ...
(Date:12/5/2014)... Calif. , Dec. 4, 2014 ... has boosted investments in new testing and inspection ... also given rise to a range of innovative ... the requirements of Generation Y, which is generally ... As a result, product development strategies of test ...
(Date:11/21/2014)... According to a new market ... RFID, Access Control, Intrusion Detection, Parking Management, Under Vehicle ... Service Geography - Global Forecasts to 2020", published by ... be around $25 Billion in 2014 and is expected ... CAGR of 8.69%. Browse 116 market data ...
Breaking Biology News(10 mins):Wearable Technology Products Demand Highly Accurate Biometric Technology 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3
... Head, SCReactive oxygen species (ROS) occur as a ... by damaging proteins, nucleotides and lipids. Organisms ... the effects of ROS, and the oxidative stress ... performance declines with age due to lifetime accrual ...
... was launched simultaneously by Global Carbon Project co-chair Michael ... the USA at Capitol Hill, Washington by GCP Executive ... posted the most recent figures for the worlds, carbon ... added to the atmosphere, the underpinning of human induced ...
... Sept. 24, 2008 Calorie restriction, a diet that is ... as effective at extending life in people as it is ... Medicine in St. Louis. Previous research had shown ... food can live up to 50 percent longer. Because of ...
Cached Biology News:Researchers discover that growing up too fast may mean dying young in honey bees 2Researchers discover that growing up too fast may mean dying young in honey bees 3Growth in the global carbon budget 2Researchers note differences between people and animals on calorie restriction 2Researchers note differences between people and animals on calorie restriction 3
(Date:12/24/2014)... and NEW YORK , Dec. 24, ... a biopharmaceutical company advancing patient care in critical areas, ... 3,500,000 shares of common stock, and warrants to purchase ... at an offering price of $4.00 per share and ... exercise price of $5.00, are exercisable immediately, and expire ...
(Date:12/24/2014)... St. Louis, Missouri (PRWEB) December 23, 2014 ... and targeting Swiss biotechnology company, Syngenta, are in the ... for pretrial proceedings. The consolidated case is In Re: ... in the U.S. District Court for the District of ... litigation (MDL) has been handed over to U.S. District ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 According to Ross ... Island Affiliate of ITRA Global, the national office market continues ... recovery. This is evidenced by the third quarter’s surprising ... market. Low energy costs have held inflation down and ... negative is the housing market remaining soft. , This solid ...
(Date:12/24/2014)... December 23, 2014 Pipette.com announces their ... Twitter followers can submit their #HolidayInTheLab pictures for a ... lab mates. , For those struggling to think of ... Pipette.com Holiday in the Lab Contest provides the ideal ... followers to send pictures of their chemistree, holiday ...
Breaking Biology Technology:PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2
... , PHILADELPHIA, June 3 Waters Corporation (NYSE: ... American Society for Mass Spectrometry (ASMS) presented Prof. ... the first Ron Hites Award for Outstanding Research ... of Mass Spectrometry (JASMS). Prof. Ashcroft,s paper titled, ...
... , Sees opportunity to end abusive use of authorized ... June 3 Mylan Inc.,s (Nasdaq: MYL ... the U.S. House of Representatives Judiciary Subcommittee on Courts ... pharmaceutical companies and generic pharmaceutical companies. During her testimony, ...
... 3 The Gamida Cell-Teva Joint Venture,announced today that five prestigious ... Valencia, have joined the Excel study. , , ... Hospital Clinic of Barcelona, Barcelona, Principal Investigator, Dr. ... Valencia, Valencia, Principal Investigator, Dr. Cristina Arbona, MD, ...
Cached Biology Technology:First ASMS Hites Award for Outstanding Research Publication Presented to Prof. Alison Ashcroft for Her Use of Waters Synapt HDMS System to Explore Protein Complexes 2First ASMS Hites Award for Outstanding Research Publication Presented to Prof. Alison Ashcroft for Her Use of Waters Synapt HDMS System to Explore Protein Complexes 3Mylan Again Calls for an End to Authorized Generics During 180-Day Exclusivity Period 2Five Cord Blood Transplant Centers in Catalonia and Valencia Join a Study to Test a New Technique to Treat Leukemia and Lymphoma 2Five Cord Blood Transplant Centers in Catalonia and Valencia Join a Study to Test a New Technique to Treat Leukemia and Lymphoma 3
Request Info...
... The Zero Blunt ... for Sequencing is designed ... sequencing of blunt-end PCR ... provides 5-minute TOPO Cloning ...
... 1 kit. Convenient way to ... Conjugations are carried out under mild conditions ... Dyes are packaged in premeasured amounts and ... Category: Blotting & Labeling & Detection, Protein ...
...
Biology Products: