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Why metastasic cells migrate
Date:3/29/2010

activated are migratory and invasive", says Martin-Blanco. "If we block the signal of Dpp in the cells, they stop moving. However, if the Dpp protein is over expressed, cells have even more and enhanced migratory and invasive capacities.

The authors have worked with embryos of the fly Drosophila melanogaster, during the formation of its abdominal epithelium, in metamorphosis. This is a process where histoblasts (embryonic cells) that will form the fly abdomen replace larval epidermal cells. The histoblasts remain at the beginning in small nests or groups of cells, and they progressively multiply, spreading and invading the space to substitute all larval epithelial cells.

This is the most clear example that scientists have seen this gene family (Dpp, BMP and TGFβ) playing the role of controlling mobility and invasiveness in normal cells. Martin-Blanco adds that "now we can study this mechanism in healthy cells, and we hope to discover more about the conditions that can inhibit or accelerate it." They expect not only to understand better this mechanism but also to find alternative strategies to inhibit metastasis.


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Contact: Ainhoa Goi
g.prensa@csic.es
0034-915-681-472
CSIC, Consejo Superior de Investigaciones Cientficas
Source:Eurekalert

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