Navigation Links
Why metastasic cells migrate
Date:3/29/2010

One of the most intriguing questions in cancer research is what causes metastatic tumour migration, why some tumour cells manage to migrate to other parts of the body but others cells don't. International investigation conducted by Enrique Martn Blanco, CSIC researcher at the Institute of Biology of Barcelona, located in the Barcelona Science Park, reveals that cells make use of a natural mechanism for this. It happens to be a family of proteins that trigger cell migration in normal processes such as growth or healing. Nevertheless, this mechanism had never been identified before in healthy cells.

The work, published in the latest issue of the Current Biology journal, is also signed by researchers at the Biozentrum from Basel University (Switzerland), and by the Universities of Coimbra (Portugal) and Freiburg (Germany).

As the authors explain, the ability of metastatic cells to migrate is not a proper mechanism of tumour cells - and therefore something that one might think is altered, but a natural ability of cells which, unfortunately, benefits metastasis.

Until now it was known that the metastasis of tumour cells can be induced by proteins such as BMPs (from 'bone morphogenetic proteins') or TGFβ (from 'transforming growth factor-β'). These proteins, identified in tumour cells of vertebrates, trigger cell migration and promote metastasis: they tell the cells that they must move and migrate, although not to where. And if these proteins are not activated in tumour cells, there is neither mobility nor invasion. But the unexplored question was if this mechanism is something exclusive of tumour cells or not.

Now the work of this international team has identified the same mechanism in the healthy cells of Drosophila melanogaster, the fruit fly.

Researchers have found that the Decapentaplegic protein (Dpp), an homologous protein of BMP and TGFβ, acts as signal of cell mobility. "The cells with Dpp activated are migratory and invasive", says Martin-Blanco. "If we block the signal of Dpp in the cells, they stop moving. However, if the Dpp protein is over expressed, cells have even more and enhanced migratory and invasive capacities.

The authors have worked with embryos of the fly Drosophila melanogaster, during the formation of its abdominal epithelium, in metamorphosis. This is a process where histoblasts (embryonic cells) that will form the fly abdomen replace larval epidermal cells. The histoblasts remain at the beginning in small nests or groups of cells, and they progressively multiply, spreading and invading the space to substitute all larval epithelial cells.

This is the most clear example that scientists have seen this gene family (Dpp, BMP and TGFβ) playing the role of controlling mobility and invasiveness in normal cells. Martin-Blanco adds that "now we can study this mechanism in healthy cells, and we hope to discover more about the conditions that can inhibit or accelerate it." They expect not only to understand better this mechanism but also to find alternative strategies to inhibit metastasis.


'/>"/>

Contact: Ainhoa Goi
g.prensa@csic.es
0034-915-681-472
CSIC, Consejo Superior de Investigaciones Cientficas
Source:Eurekalert

Related biology news :

1. ESF EURYI award winner aims to stop cancer cells reading their own DNA
2. Newly created cancer stem cells could aid breast cancer research
3. AIDS interferes with stem cells in the brain
4. Clemson scientists shed light on molecules in living cells
5. Social habits of cells may hold key to fighting diseases
6. UF scientists reveal how dietary restriction cleans cells
7. Human derived stem cells can repair rat hearts damaged by heart attack
8. Scientists identify embryonic stem cells by appearance alone
9. Cells united against cancer
10. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
11. U of M begins nations first clinical trial using T-reg cells from cord blood in leukemia treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2017)... -- RAM Group , Singaporean based technology ... biometric authentication based on a novel  quantum-state ... perform biometric authentication. These new sensors are based on a ... Group and its partners. This sensor will have widespread ... security. Ram Group is a next generation sensor ...
(Date:4/19/2017)... 19, 2017 The global military ... is marked by the presence of several large global ... by five major players - 3M Cogent, NEC Corporation, ... for nearly 61% of the global military biometric market ... the global military biometrics market boast global presence, which ...
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... Annual Report on Form 10-K on Thursday April 13, 2017 with ... ... Relations section of the Company,s website at http://www.nxt-id.com  under "SEC ... . 2016 Year Highlights: Acquisition ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased ... of over 5.5 million people each year. Especially those living in larger cities are ... - based in one of the most pollution-affected countries globally - decided to take ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... (ADC) therapeutics, today confirmed licensing rights that give it exclusive global access ... developed in collaboration with Children’s Hospital Los Angeles (CHLA). Additionally, an ...
(Date:10/10/2017)... SomaGenics announced the receipt of a Phase ... (Single Cell), expected to be the first commercially available ... from single cells using NGS methods. The NIH,s recent ... development of approaches to analyze the heterogeneity of cell ... for measuring levels of mRNAs in individual cells have ...
(Date:10/9/2017)... ... 2017 , ... The award-winning American Farmer television series will feature 3 Bar ... Tuesdays at 8:30aET on RFD-TV. , With global population estimates nearing ten billion ... continue to feed a growing nation. At the same time, many of our valuable ...
Breaking Biology Technology: