Navigation Links
Why metastasic cells migrate
Date:3/29/2010

One of the most intriguing questions in cancer research is what causes metastatic tumour migration, why some tumour cells manage to migrate to other parts of the body but others cells don't. International investigation conducted by Enrique Martn Blanco, CSIC researcher at the Institute of Biology of Barcelona, located in the Barcelona Science Park, reveals that cells make use of a natural mechanism for this. It happens to be a family of proteins that trigger cell migration in normal processes such as growth or healing. Nevertheless, this mechanism had never been identified before in healthy cells.

The work, published in the latest issue of the Current Biology journal, is also signed by researchers at the Biozentrum from Basel University (Switzerland), and by the Universities of Coimbra (Portugal) and Freiburg (Germany).

As the authors explain, the ability of metastatic cells to migrate is not a proper mechanism of tumour cells - and therefore something that one might think is altered, but a natural ability of cells which, unfortunately, benefits metastasis.

Until now it was known that the metastasis of tumour cells can be induced by proteins such as BMPs (from 'bone morphogenetic proteins') or TGFβ (from 'transforming growth factor-β'). These proteins, identified in tumour cells of vertebrates, trigger cell migration and promote metastasis: they tell the cells that they must move and migrate, although not to where. And if these proteins are not activated in tumour cells, there is neither mobility nor invasion. But the unexplored question was if this mechanism is something exclusive of tumour cells or not.

Now the work of this international team has identified the same mechanism in the healthy cells of Drosophila melanogaster, the fruit fly.

Researchers have found that the Decapentaplegic protein (Dpp), an homologous protein of BMP and TGFβ, acts as signal of cell mobility. "The cells with Dpp
'/>"/>

Contact: Ainhoa Goi
g.prensa@csic.es
0034-915-681-472
CSIC, Consejo Superior de Investigaciones Cientficas
Source:Eurekalert

Page: 1 2

Related biology news :

1. ESF EURYI award winner aims to stop cancer cells reading their own DNA
2. Newly created cancer stem cells could aid breast cancer research
3. AIDS interferes with stem cells in the brain
4. Clemson scientists shed light on molecules in living cells
5. Social habits of cells may hold key to fighting diseases
6. UF scientists reveal how dietary restriction cleans cells
7. Human derived stem cells can repair rat hearts damaged by heart attack
8. Scientists identify embryonic stem cells by appearance alone
9. Cells united against cancer
10. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
11. U of M begins nations first clinical trial using T-reg cells from cord blood in leukemia treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... Health at the Mailman School of Public Health are ... and prenatal exposure to two phthalates used in a ... the journal Environmental Health Perspectives . , ... levels of the chemicals, butylbenzyl phthalate (BBzP) and di-n-butyl ... increase in risk of developing asthma between age 5 ...
(Date:9/16/2014)... Ohio (September 17, 2014)The North American Menopause Society ... the comprehensive care of midlife womenon everything from ... "The North American Menopause Society Recommendations for Clinical ... in the Society,s journal Menopause . This ... for the care of midlife women freely available ...
(Date:9/16/2014)... the "molecular brakes" that time the generation of important ... "hair cells" translate sound waves into electrical signals that ... sounds. If the arrangement of the cells is disordered, ... research will be published in The Journal of ... and Hey2 act as brakes to prevent hair cell ...
Breaking Biology News(10 mins):Phthalates heighten risk for childhood asthma 2Phthalates heighten risk for childhood asthma 3Hey1 and Hey2 ensure inner ear 'hair cells' are made at the right time, in the right place 2
... Virginia Commonwealth University immunologists studying mast cells, known to ... have identified a hormone-like molecule that can kill these ... mice. , The findings move researchers another step ... and may help researchers develop new treatments for allergy ...
... day, tens of thousands of biologists around the globe ... online algorithm called BLAST ?typically submitting 200 to 400 ... matched against the billions of letters for known genes. ... or evolutionary relationships, scientists routinely use BLAST to churn ...
... captures pictures beneath the living brain's surfaceResearchers at Stanford ... that can capture micron-scale images from deep in the ... combines a pair of powerful optical and mechanical techniques ... the hand. The results appear in the September 1, ...
Cached Biology News:VCU study shows hormone-like molecule kills cells that cause inflammation in allergic disease 2Drawing with DNA: 'Bioart' illuminates genomics 2Drawing with DNA: 'Bioart' illuminates genomics 3Microscopic brain imaging in the palm of your hand 2Microscopic brain imaging in the palm of your hand 3
(Date:9/17/2014)... 2014 Hussey Copper , a leader ... antimicrobial copper, announces Gilmour Academy Ice Arena,s conversion of ... antimicrobial solid touch surface to help protect against bacteria.  ... surface that kills greater than 99.9% of MRSA, E-coli ... , Innovative ...
(Date:9/17/2014)... , Sept. 17, 2014 Veracyte, ... diagnostics company pioneering the field of molecular cytology, today ... operating officer. Mr. Hall joined Veracyte in ... commercial entry into endocrinology. Since 2012, he has led ... as managed care and billing functions. As chief operating ...
(Date:9/17/2014)... 2014 Beckman Coulter , a ... healthcare, has renewed its agreement with Personify ... the agreement, Personify will continue to streamline the Beckman ... recruitment analytics, including time-to-fill, time-to-source and a deep reduction ... with Personify was based on the success of our ...
(Date:9/17/2014)... NASA’s MESSENGER has just celebrated its 10 year ... have one of its latch valves, V27200-818, operating onboard ... investigation of the planet Mercury. It is only the ... provided a vast amount of information and images of ... utilize solenoids that also include permanent magnets to maintain ...
Breaking Biology Technology:Innovative Gilmour Academy Ice Arena changes more than 200 fixtures to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 2Innovative Gilmour Academy Ice Arena changes more than 200 fixtures to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 3Veracyte, Inc. Announces Promotion of Christopher M. Hall To Chief Operating Officer 2Veracyte, Inc. Announces Promotion of Christopher M. Hall To Chief Operating Officer 3Veracyte, Inc. Announces Promotion of Christopher M. Hall To Chief Operating Officer 4Beckman Coulter Signs 3-year RPO Contract with Personify 2Beckman Coulter Signs 3-year RPO Contract with Personify 3
... China, Dec. 15 /PRNewswire-Asia/ -- China Medicine ... "the Company"), a leading,developer and distributor of ... medicines (TCM), nutritional and dietary supplements,medical devices ... from,the Guangdong Food & Drug Administration to ...
... to Support Phase 3 Combination Rule Trial for NDA ... Australia and BEDMINSTER, N.J., Dec. 15 QRxPharma Limited ... company focused on the development and commercialization of therapies ... today initiation of a comparative study to evaluate the ...
... Platform Brings System Flexibility and Efficiency to the Advanced ... Scanning Systems , , ... confocal microscope and software package available, Nikon Instruments, Inc.,s ... scanning systems with dedicated NIS-Elements C software brings biological ...
Cached Biology Technology:China Medicine to Distribute Dental and Surgical Instruments 2China Medicine to Distribute Dental and Surgical Instruments 3QRxPharma Initiates Comparative Study for MoxDuoIR(TM) Dual-Opioid(TM) Pain Therapy 2QRxPharma Initiates Comparative Study for MoxDuoIR(TM) Dual-Opioid(TM) Pain Therapy 3Nikon Instruments A1 Confocal Laser Microscope Series With NIS-Elements C Software Delivers Fully Integrated Comprehensive Confocal Imaging Capabilities 2Nikon Instruments A1 Confocal Laser Microscope Series With NIS-Elements C Software Delivers Fully Integrated Comprehensive Confocal Imaging Capabilities 3
... 2D is an automated, two-dimensional fractionation system ... Part of Beckman Coulters ProteomeLab family ... in just hours. The system effectively ... cell lysates, addressing a key challenge in ...
... cDNA Library Panels were designed for full-length ... of PCRs to identify the desired cDNA ... in a 96-well "Master Plate," where each ... Having identified the positive well(s) by gel ...
... Jobin Yvons Protein 295 ex can measure ... sample in only a few minutes. To ... acids tyrosine and tryptophan, the Protein 295 ... a pulsed diode emitting 295 nm. Fluorescence ...
... is a research grade spectrofluorometer which offers ... speeds of up to 60,000nm/min. Its ... concentrated light beam along with low sample ... FL Solutions, PC fluorescence applications software, which ...
Biology Products: