Navigation Links
Why 'lazy Susan' has a weak heart
Date:3/5/2009

When young, apparently healthy athletes suddenly collapse, it can be due to hereditary cardiac disease. Researchers at the Heidelberg University Hospital have now discovered a genetic modification that leads to cardiac weakness in an animal model. Just one "false" amino acid can give zebrafish a heart condition. Since the fish have a genetic makeup similar to that of humans, these defects could be critical for humans as well.

Cardiac insufficiency is not just a disease that results from a heart attack or myocarditis. For young people in particular there is often an underlying genetic cause (cardiomyopathy). Some 30,000 people in Germany are affected and the disease often remains undetected for a long time. The tragic cases of athletes who suddenly collapse during training or competition are well known. The cardiology department at the Heidelberg University Hospital (Medical Director Prof. Hugo Katus) is one of the major centers in Germany for the treatment and research of cardiac insufficiency.

For many years, the researchers in Heidelberg have been studying the zebrafish. The genetic variant that suffers from cardiomyopathy is called "Lazy Susan" and got its nickname because of its slow blood flow. Dr. Benjamin Meder and Christina Laufer from Dr. Wolfgang Rottbauer's research group (Department of Cardiology) examined its muscle protein myosin light chain-1, which is involved in contraction of the heart muscle. They discovered the crucial change in the amino acid Serine 195, which was lost through mutation. This single change is sufficient to severely limit heart function.

Some 70 percent of the genes of zebrafish and humans are identical

Can these research results be transferred from zebrafish to humans? In the next step, the Heidelberg cardiologists plan to search for the same mutation in patients' genes. Since approximately 70 percent of human genes are identical with those of zebrafish, the researchers are confident that a Serine 195 mutation will have a similar affect in human hearts. The researchers also hope to develop new therapies for patients. A targeted modification of the amino acid Serine could increase the activity of the actin-myosin complex and result in an increase of cardiac contractility.


'/>"/>

Contact: Dr. Benjamin Meder
Benjamin.Meder@med.uni-heidelberg.de
062-215-64835
University Hospital Heidelberg
Source:Eurekalert

Related biology news :

1. Type 1 diabetes triggered by lazy regulatory T-cells: McGill researchers
2. Abnormal fat metabolism underlies heart problems in diabetic patients
3. High blood pressure, low energy -- a recipe for heart failure
4. Human derived stem cells can repair rat hearts damaged by heart attack
5. Geron Demonstrates hESC-derived cardiomyocytes improve heart function after myocardial infarction
6. Heart of Herschel to be presented to media
7. Minimally invasive heart surgery research wins NIH award
8. A step toward tissue-engineered heart structures for children
9. Research explains link between cholesterol and heart disease
10. Eating competence may lower risk of heart disease
11. Cardiologists and heart surgeons meet for Controversies and Advances conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... , May 3, 2016  Neurotechnology, a provider ... MegaMatcher Automated Biometric Identification System (ABIS) , ... multi-biometric projects. MegaMatcher ABIS can process multiple complex ... any combination of fingerprint, face or iris biometrics. ... SDK and MegaMatcher Accelerator , which ...
(Date:4/26/2016)... India and LONDON ... Infosys Finacle, part of EdgeVerve Systems, a product ... and Onegini today announced a partnership to integrate ... solutions.      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ... to provide their customers enhanced security to access ...
(Date:4/15/2016)...  A new partnership announced today will help ... in a fraction of the time it takes ... life insurance policies to consumers without requiring inconvenient ... Diagnostics, rapid testing (A1C, Cotinine and HIV) and ... weight, pulse, BMI, and activity data) available at ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , June 27, 2016 /PRNewswire/ - BIOREM Inc. (TSX-V: BRM) ... advised by its major shareholders, Clean Technology Fund I, ... United States based venture capital funds which ... Biorem (on a fully diluted, as converted basis), that ... of their entire equity holdings in Biorem to TUS ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... will join the faculty of the University of North Carolina Kenan-Flagler Business ... strategy and entrepreneurship at UNC Kenan-Flagler, with a focus on the school’s international ...
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers ... 5000 and the 6000i models are higher end machines that use the more unconventional ... spectrophotometer’s light beam from the bottom of the cuvette holder. , FireflySci has ...
(Date:6/23/2016)... TORONTO , June 23, 2016 /PRNewswire/ - ... Ontario biotechnology company, Propellon ... the development and commercialization of a portfolio of ... cancers. Epigenetic targets such as WDR5 represent an ... contribute significantly in precision medicine for cancer patients. ...
Breaking Biology Technology: