Navigation Links
Why 'lazy Susan' has a weak heart
Date:3/5/2009

When young, apparently healthy athletes suddenly collapse, it can be due to hereditary cardiac disease. Researchers at the Heidelberg University Hospital have now discovered a genetic modification that leads to cardiac weakness in an animal model. Just one "false" amino acid can give zebrafish a heart condition. Since the fish have a genetic makeup similar to that of humans, these defects could be critical for humans as well.

Cardiac insufficiency is not just a disease that results from a heart attack or myocarditis. For young people in particular there is often an underlying genetic cause (cardiomyopathy). Some 30,000 people in Germany are affected and the disease often remains undetected for a long time. The tragic cases of athletes who suddenly collapse during training or competition are well known. The cardiology department at the Heidelberg University Hospital (Medical Director Prof. Hugo Katus) is one of the major centers in Germany for the treatment and research of cardiac insufficiency.

For many years, the researchers in Heidelberg have been studying the zebrafish. The genetic variant that suffers from cardiomyopathy is called "Lazy Susan" and got its nickname because of its slow blood flow. Dr. Benjamin Meder and Christina Laufer from Dr. Wolfgang Rottbauer's research group (Department of Cardiology) examined its muscle protein myosin light chain-1, which is involved in contraction of the heart muscle. They discovered the crucial change in the amino acid Serine 195, which was lost through mutation. This single change is sufficient to severely limit heart function.

Some 70 percent of the genes of zebrafish and humans are identical

Can these research results be transferred from zebrafish to humans? In the next step, the Heidelberg cardiologists plan to search for the same mutation in patients' genes. Since approximately 70 percent of human genes are identical with those of zebrafish, the researchers are confi
'/>"/>

Contact: Dr. Benjamin Meder
Benjamin.Meder@med.uni-heidelberg.de
062-215-64835
University Hospital Heidelberg
Source:Eurekalert

Page: 1 2

Related biology news :

1. Type 1 diabetes triggered by lazy regulatory T-cells: McGill researchers
2. Abnormal fat metabolism underlies heart problems in diabetic patients
3. High blood pressure, low energy -- a recipe for heart failure
4. Human derived stem cells can repair rat hearts damaged by heart attack
5. Geron Demonstrates hESC-derived cardiomyocytes improve heart function after myocardial infarction
6. Heart of Herschel to be presented to media
7. Minimally invasive heart surgery research wins NIH award
8. A step toward tissue-engineered heart structures for children
9. Research explains link between cholesterol and heart disease
10. Eating competence may lower risk of heart disease
11. Cardiologists and heart surgeons meet for Controversies and Advances conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... , Kina, 31. juli 2015 Den ... bliver afholdt af BGI fra den 22. - 25. oktober ... Konferencen fejrer sin 10-års fødselsdag i år. Siden ... mest indflydelsesrige årlige møder på ,omik,-feltet, og er en ... ICG-10 fokuserer på nylige gennembrud og ...
(Date:7/31/2015)... , 31 de julho de 2015 ... www.icg-10.org ) será realizada pela BGI de 22-25 de ... . A conferência está celebrando seu 10 ... 2006, a ICG se tornou uma das reuniões mais ... dos encontros científicos mais dinâmicos, entusiastas e prazerosos. ...
(Date:7/31/2015)... La 10 th International Conference on Genomics ... 22 al 25 de octubre de 2015 en ... conferencia celebra su décimo aniversario. Desde su inauguración en el ... reuniones anuales más influyentes del mundo en el campo ,ómico, ... y mejores a nivel científico. ICG-10 se ...
Breaking Biology News(10 mins):Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 2La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 3
... universe began and evolved will be discussed in a free public ... a professor in UCR,s Department of Physics and Astronomy , ... stars and galaxies, formed 13 billion years ago when the universe ... titled "Let There Be Light: The First Billion Years," will be ...
... Medical School geneticists have made new inroads into understanding ... the ebb and flow of daily activities, according to ... on the relationship between clocks and temperature, reported in ... of temperature compensation: why the 24-hour circadian rhythm does ...
... announced May 15th the winners of its competition for ... cash prizes were awarded in this first competition, which ... about plant life. Grand prize winner ... WA, for his entry entitled "Fertile Eyes". The video ...
Cached Biology News:Public lecture at UC Riverside to discuss origin and fate of universe 2Two new studies on circadian rhythms 2
(Date:9/2/2015)... Sept. 2, 2015 Research and ... addition of Jain PharmaBiotech,s new report ... their offering. An increasing ... biotechnology industries is anticipated. Nanotechnology will be ... - from formulations for optimal delivery to ...
(Date:9/2/2015)... , Sep. 02, 2015 ... has announced the addition of Jain PharmaBiotech,s new ... and Companies" to their offering. ... based on technologies and applications. The report starts ... for estimation of markets. Technologies include array comparative ...
(Date:9/2/2015)... 2015 Research and Markets ... PharmaBiotech,s new report "Gene Therapy - Technologies, Markets ... markets for gene therapy are difficult to estimate as ... it is marketed in China ... years 2014-2024. The estimates are based on epidemiology of ...
(Date:9/2/2015)... Mass. (PRWEB) , ... September 02, 2015 , ... ... includes development of botanical and plant-derived compounds. BCC Research reveals in its ... past 2020 because this market defines the category and generates the most market ...
Breaking Biology Technology:Global Nanobiotechnology Applications, Markets and Companies Report 2015-2024 2Global Nanobiotechnology Applications, Markets and Companies Report 2015-2024 3Global Biochips and Microarrays Technologies, Markets and Companies Report 2015 with Market Size in 2014 and Projected Value for the Years 2019 and 2024 2Global Gene Therapy Market Study 2015-2024 - Technologies, Markets and Companies Analysis 2Plant-derived Compounds Poised to Assume Greater Role in Global Drug Markets, According to BCC Research 2Plant-derived Compounds Poised to Assume Greater Role in Global Drug Markets, According to BCC Research 3
... research team announced on Sunday they have successfully created ... that could affect some of the ethical debate over ... University of Wisconsin-Madison professor cautions that the breakthrough has ... Web site of the research journal Science, ...
... -- Wisconsin has made significant progress in improving ... more to relieve investment restrictions if the state is ... committee heard on Tuesday. , ,"Today it is easier ... is to invest in emerging, growth Wisconsin companies," said ...
... article is the first in a new UW E-Business ... University of Wisconsin E-Business Consortium in 2002. , ... creative appliance design. The brand those valued consumers turn ... ,Sub-Zero's built-in refrigeration units can be seamlessly integrated to ...
Cached Biology Technology:Harvard advance improves stem cell research; not a medical revolution 2Regulations still stymie business investment in high-growth companies 2Regulations still stymie business investment in high-growth companies 3Regulations still stymie business investment in high-growth companies 4How Sub-Zero Freezer Co. uses technology to revolutionize customer service 2How Sub-Zero Freezer Co. uses technology to revolutionize customer service 3
Mouse monoclonal [3G131] to Desmoglein 1 ( Abpromise for all tested applications). entrezGeneID: 1828 SwissProtID: Q02413...
TCP-1 alpha (H-110)...
Synphilin 1 Immunogen: Synthetic peptide corresponding to residues S(829) L E L N G E K D K D K G R T L Q R T(847) of human Synphilin 1. Storage: -20 C, Avoid Freeze/Thaw Cycles...
COMING SOON: Anti-Mouse C5/C5b, Clone BB5.1. Monoclonal Antibody...
Biology Products: