Navigation Links
Why is the measles virus so contagious?
Date:11/4/2011

An international collaboration involving Inserm has revealed how the measles virus leaves the body of an infected person to contaminate another individual. The researchers have identified a key receptor, located in the trachea, which allows the virus to spread through the air rapidly from one organism to another. The receptor, nectine-4, is also known to be a biomarker for some cancers.

This research appeared in a letter, dated 2 November 2011, published in Nature.

The measles virus is one of the most highly contagious human pathogens and can cause serious, sometimes fatal, complications. It is mainly transmitted when an infected person coughs or sneezes, sending droplets through the air to another individual. This explains why the virus spreads so rapidly through at-risk populations (i.e. persons who are not vaccinated or improperly vaccinated), obstructing world vaccination programmes that seek to eradicate it. Every year, this virus infects more than 10 million children and causes 120,000 deaths in the world. France also faces a measles epidemic that is giving cause for concern. While only forty or so cases were reported in 2006 and 2007, numbers have risen sharply since 2008 (14,600 cases have already been reported since the beginning of 2011) .

The discovery published in the journal Nature explains why this virus spreads so quickly. Viruses generally use cell receptors to initiate and spread the infection throughout the organism. This is the case of the measles virus, which infects the immune cells in the lungs to enter and spread through the body. For the first time ever, this study shows how the measles virus uses another receptor (nectine-4) to 'leave' its host. Nectine-4 is located specifically in the trachea, a part of the anatomy that is 'ideally' suited to airborne contagion.

Interesting prospects for cancer treatment

Nectine-4 is a biomarker for certain types of cancer, including b
'/>"/>

Contact: Inserm Press Office
presse@inserm.fr
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers test inhalable measles vaccine
2. Measles virus plays role in Pagets disease of bone, Pitt-led team says
3. Measles virus, a weapon against cancer?
4. Mayo researchers describe measles viral protein movement
5. West Nile virus transmission linked with land-use patterns and super-spreaders
6. Scientists report major advance in human antibody therapy against deadly Hendra virus
7. Pitt biologists find surprising number of unknown viruses in sewage
8. Manipulated gatekeeper: How viruses find their way into the cell nucleus
9. XMRV, related viruses not confirmed in blood of healthy donors or chronic fatigue syndrome patients
10. Cowpox virus: Old friend but new foe
11. Team finds stable RNA nano-scaffold within virus core
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... The use of iodine-125 (125I) in cancer treatment ... dorsal root ganglia are critical for neural transmission ... Tengda Zhang and colleagues from Institute of Radiation ... that 125I could be implanted into rat dorsal ... pain. 125I seeds with different radioactivity (0, 14.8, ...
(Date:7/30/2014)... analysis of the roughly 3,000 pieces is still in ... the results will be of major significance. "Amazingly often, ... species in Fushun amber that we found in Baltic ... , The Baltic amber comes from the Baltic Sea ... rich in finds are, e.g., the coastal regions of ...
(Date:7/30/2014)... journal Scientific Reports , published by Nature ... that while global temperature is indeed increasing, so too ... each year,s average hottest and coldest temperatures will likely ... a wider range of potential high and low temperate ... even as overall temperatures rise, we may still continue ...
Breaking Biology News(10 mins):Chinese mosquitos on the Baltic Sea 2Big data confirms climate extremes are here to stay 2
... LONDON , April 27, 2010 Dominio Amigo S.A.S ... the .CO domain name launch. , , ... Julio Camacho , CEO, Dominio Amigo S.A.S , ... have consistently performed,at both ccTLD and gTLD launches, securing the very best Internet ...
... LONDON , April 27, 2010 ... backdrop. In,a video interview with online financial broadcaster http://www.cantos.com ,Chief Executive ... which,demonstrates the resilience of our business and the success of our enhanced,focus ... ...
... , April 27 The PMI Group, Inc. (NYSE: ... sell in concurrent underwritten public offerings an aggregate of 77,765,000 shares ... $6.15 per share and $261 million aggregate ... connection with the offerings, PMI has granted the underwriters 30-day options ...
Cached Biology News:Dominio Amigo Announce Domainmonster as .CO Technical Partner 2Dominio Amigo Announce Domainmonster as .CO Technical Partner 3Imperial Tobacco - 2010 Half Year Results Interviews 2The PMI Group, Inc. Announces Pricing of Common Stock and Convertible Senior Notes Offerings 2The PMI Group, Inc. Announces Pricing of Common Stock and Convertible Senior Notes Offerings 3The PMI Group, Inc. Announces Pricing of Common Stock and Convertible Senior Notes Offerings 4
(Date:7/30/2014)... 30, 2014 NCERC at Southern ... present his findings on corn stover pretreatment methods ... week in Washington, D.C. , “Arun’s selection ... is a testament to the success of our ... “Thanks to the foresight and vision of SIUE ...
(Date:7/30/2014)... LayerBio, Inc., an MIT spinoff developing ... round of seed financing from friends and family investors. ... develop a novel sustained-release product for ophthalmology. , "We ... their commitment to this important work," said Dr. Ken ... of many areas in which innovations in drug delivery ...
(Date:7/29/2014)...   Sequenom, Inc. (NASDAQ: SQNM ... analysis solutions, and Mayo Medical Laboratories (MML), ... the United States , have announced a ... "We have great appreciation for Mayo Clinic,s ... welcome the opportunity to partner with the organization,s leading ...
(Date:7/29/2014)... ELLICOTT CITY, Md. , July 29, 2014 ... has announced a new and updated program for ... October 10 – 12, 2014 in Amelia ... sponsors, CROs, sites and investigators remains unchanged, however, ... more purposeful exchange and networking opportunity among all ...
Breaking Biology Technology:NCERC at SIUE Researcher Takes Stage at Department of Energy Conference 2NCERC at SIUE Researcher Takes Stage at Department of Energy Conference 3Sequenom Enters Into License Agreement With Mayo Medical Laboratories 2Sequenom Enters Into License Agreement With Mayo Medical Laboratories 3Sequenom Enters Into License Agreement With Mayo Medical Laboratories 4TransCelerate, Lilly, Pfizer, and FDA Highlight Collaborative Program at the Site Solutions Summit 2TransCelerate, Lilly, Pfizer, and FDA Highlight Collaborative Program at the Site Solutions Summit 3
... Management to discuss positive corporate developments and ... call, SANTA CLARA, Calif., Oct. 14 ... cardiac diagnostic and services company, today,announced that ... discuss,recent corporate developments and provide an update ...
... release date, NATICK, Mass., Oct. 14 ... the following comments reinforcing,the strength of its balance ... and the Company,s stock price,volatility have had no ... performance of the Company. Strong cash flow generation,during ...
... China, Oct. 14 /Xinhua-PRNewswire/ -- WuXi PharmaTech,(Cayman) ... pharmaceutical, biotechnology and,medical device research and development ... United States, today announced preliminary selected,unaudited financial ... 30, 2008,and updated its guidance for the ...
Cached Biology Technology:NewCardio Management to Host Conference Call on October 21 2NewCardio Management to Host Conference Call on October 21 3Boston Scientific Provides Comments Reinforcing Strength of Its Balance Sheet 2Boston Scientific Provides Comments Reinforcing Strength of Its Balance Sheet 3WuXi PharmaTech Announces Preliminary Third Quarter 2008 Results and Updates 2008 Guidance 2WuXi PharmaTech Announces Preliminary Third Quarter 2008 Results and Updates 2008 Guidance 3WuXi PharmaTech Announces Preliminary Third Quarter 2008 Results and Updates 2008 Guidance 4WuXi PharmaTech Announces Preliminary Third Quarter 2008 Results and Updates 2008 Guidance 5WuXi PharmaTech Announces Preliminary Third Quarter 2008 Results and Updates 2008 Guidance 6WuXi PharmaTech Announces Preliminary Third Quarter 2008 Results and Updates 2008 Guidance 7WuXi PharmaTech Announces Preliminary Third Quarter 2008 Results and Updates 2008 Guidance 8
... These handy dispensers save space and ... and other garb. They are the ... parts used in labs, processing and ... charges and the particles they attract. ...
... for genome-wide microRNA expression profiling and ... Paraflo microfluidic on-chip synthesis platform. These ... our comprehensive microRNA Expression Profiling Service. ... Rice microRNA Microarray contains all known ...
... is the research-grade spectrofluorometer with a minimum ... S/N ratio 200 or greater for the ... especially designed to keep in mind in ... kinetics, stopped-flow, titration, or anisotropic measurements. ,The ...
... Microarrays designed for genome-wide microRNA ... flexible and powerful Paraflo microfluidic on-chip ... as part of our comprehensive microRNA ... Content The Fishes microRNA Microarray ...
Biology Products: