Navigation Links
Why is the measles virus so contagious?
Date:11/4/2011

An international collaboration involving Inserm has revealed how the measles virus leaves the body of an infected person to contaminate another individual. The researchers have identified a key receptor, located in the trachea, which allows the virus to spread through the air rapidly from one organism to another. The receptor, nectine-4, is also known to be a biomarker for some cancers.

This research appeared in a letter, dated 2 November 2011, published in Nature.

The measles virus is one of the most highly contagious human pathogens and can cause serious, sometimes fatal, complications. It is mainly transmitted when an infected person coughs or sneezes, sending droplets through the air to another individual. This explains why the virus spreads so rapidly through at-risk populations (i.e. persons who are not vaccinated or improperly vaccinated), obstructing world vaccination programmes that seek to eradicate it. Every year, this virus infects more than 10 million children and causes 120,000 deaths in the world. France also faces a measles epidemic that is giving cause for concern. While only forty or so cases were reported in 2006 and 2007, numbers have risen sharply since 2008 (14,600 cases have already been reported since the beginning of 2011) .

The discovery published in the journal Nature explains why this virus spreads so quickly. Viruses generally use cell receptors to initiate and spread the infection throughout the organism. This is the case of the measles virus, which infects the immune cells in the lungs to enter and spread through the body. For the first time ever, this study shows how the measles virus uses another receptor (nectine-4) to 'leave' its host. Nectine-4 is located specifically in the trachea, a part of the anatomy that is 'ideally' suited to airborne contagion.

Interesting prospects for cancer treatment

Nectine-4 is a biomarker for certain types of cancer, including breast, ovarian and lung cancer. Treatments based on the use of a modified vaccine strain of the measles virus are currently being developed for use against some cancers. This virus replicates preferentially in cancer cells, leading to their destruction. The presence of this biomarker in tumours must be taken into consideration to improve the efficacy of these novel therapeutic methods.


'/>"/>

Contact: Inserm Press Office
presse@inserm.fr
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

Related biology news :

1. Researchers test inhalable measles vaccine
2. Measles virus plays role in Pagets disease of bone, Pitt-led team says
3. Measles virus, a weapon against cancer?
4. Mayo researchers describe measles viral protein movement
5. West Nile virus transmission linked with land-use patterns and super-spreaders
6. Scientists report major advance in human antibody therapy against deadly Hendra virus
7. Pitt biologists find surprising number of unknown viruses in sewage
8. Manipulated gatekeeper: How viruses find their way into the cell nucleus
9. XMRV, related viruses not confirmed in blood of healthy donors or chronic fatigue syndrome patients
10. Cowpox virus: Old friend but new foe
11. Team finds stable RNA nano-scaffold within virus core
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ITHACA, N.Y. , June 23, 2017 /PRNewswire/ ... leader in dairy research, today announced a new collaboration ... reduce the chances that the global milk supply is ... dairy project, Cornell University has become the newest academic ... Supply Chain, a food safety initiative that includes IBM ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/18/2017)... a global expert in SoC-based imaging and computing solutions, has developed ... the company,s hybrid codec technology. A demonstration utilizing TeraFaces ® , ... showcased during the upcoming Medtec Japan at Tokyo Big Sight April ... Vegas Convention Center April 24-27. ... Click here for an image of the M820 ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Singh ... orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of ... SBT-100 is able to cross the cell membrane and bind intracellular STAT3 and ...
(Date:10/10/2017)... Philadelphia, PA (PRWEB) , ... October 10, 2017 ... ... University City Science Center’s FirstHand program has won a US2020 STEM Mentoring Award. ... accept the award for Excellence in Volunteer Experience from US2020. , US2020’s mission ...
(Date:10/10/2017)... 2017 SomaGenics announced the receipt of a ... RealSeq®-SC (Single Cell), expected to be the first commercially ... microRNAs) from single cells using NGS methods. The NIH,s ... accelerate development of approaches to analyze the heterogeneity of ... techniques for measuring levels of mRNAs in individual cells ...
(Date:10/9/2017)...  BioTech Holdings announced today identification and patenting ... stem cell therapy prevents limb loss in animal ... that treatment with ProCell resulted in more than ... to standard bone marrow stem cell administration.  Interestingly, ... of therapeutic effect.  ...
Breaking Biology Technology: