Navigation Links
Why getting healthy can seem worse than getting sick
Date:3/20/2012

A new article in The Quarterly Review of Biology helps explain why the immune system often makes us worse while trying to make us well.

The research offers a new perspective on a component of the immune system known as the acute-phase response, a series of systemic changes in blood protein levels, metabolic function, and physiology that sometimes occurs when bacteria, viruses, or other pathogens invade the body. This response puts healthy cells and tissue under serious stress, and is actually the cause of many of the symptoms we associate with being sick.

"The question is why would these harmful components evolve," asks Edmund LeGrand (University of Tennessee, Knoxville), who wrote the paper titled with Joe Alcock (University of New Mexico). The researchers contend that answer becomes clear when we view the acute-phase response in terms of what they call "immune brinksmanship."

The immune brinksmanship model "is the gamble that systemic stressors will harm the pathogens relatively more than the host," LeGrand said. The concept, he explains, is akin to what happens in international trade disputes. When one country places trade sanctions on another, both countries' economies take a hit, but the sanctioning country is betting that its opponent will be hurt more.

"One of our contributions here is to pull together the reasons why pathogens suffer more from systemic stress," LeGrand said.

The acute-phase response creates stress in several ways. It raises body temperature and causes loss of appetite and mild anemia. At the same time, certain vital nutrients like iron, zinc, and manganese are partially sequestered away from the bloodstream.

Some of these components are quite puzzling. Why reduce food intake just when one would expect more energy would be needed to mount a strong immune response? Zinc is essential for healthy immune function. Why pull it out of the bloodstream when the immune system is act
'/>"/>

Contact: Kevin Stacey
kstacey@press.uchicago.edu
401-284-3878
University of Chicago Press Journals
Source:Eurekalert

Page: 1 2

Related biology news :

1. Getting cancer cells to swallow poison
2. Panama REDD: Getting what you pay for
3. Pregnant women in Vancouver may not be getting enough vitamin D
4. Getting 50-year-old Americans as healthy as Europeans could save Medicare and Medicaid $632 billion by 2050
5. Americans still may not be getting enough calcium
6. Getting closer to a better biocontrol for garden pests
7. Getting organized: Berkeley Lab study shows how breast cell communities organize into breast tissue
8. Getting rid of cattle fever ticks
9. Getting a tail up on conservation?
10. Warning system inadequate to prevent swimmers from getting sick at inland lakes
11. Getting a step ahead of pathogens
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/15/2015)... , Jun. 15, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... on the growing mobile commerce market, announces that its leading ... to media at Digital Experience! @ NYC June 18th. ... of the latest innovation in technology to over 300 of ... held at the Metropolitan Pavilion in New York ...
(Date:6/10/2015)... , June 10, 2015 ... "3D Sensor Market by Technology (Ultrasound, TOF, Structured ... (consumer Electronics, Entertainment, Automotive) and by Geography - ... by MarketsandMarkets, the market is expected to reach ... of 25.51% between 2015 and 2020. ...
(Date:6/8/2015)... , June 8, 2015  Trovagene, Inc. (NASDAQ: TROV ... clinical data featuring its Precision Cancer Monitoring SM platform ... Liquid Biopsies conference in San Diego, CA ... Precision Medicine Series: Integrating Clinical Genomics and Cancer Therapy ... June 13-16. "We continue to advance our ...
Breaking Biology News(10 mins):Wocket Smart Wallet Exhibiting at Pepcom Digital Experience! @ NYC June 18th 2Wocket Smart Wallet Exhibiting at Pepcom Digital Experience! @ NYC June 18th 33D Sensor Market Worth $3,319.71 Million by 2020 23D Sensor Market Worth $3,319.71 Million by 2020 33D Sensor Market Worth $3,319.71 Million by 2020 4Clinical Data Featuring Trovagene's Urine-Based Liquid Biopsy Platform to be Presented at Two Upcoming Medical Conferences 2Clinical Data Featuring Trovagene's Urine-Based Liquid Biopsy Platform to be Presented at Two Upcoming Medical Conferences 3Clinical Data Featuring Trovagene's Urine-Based Liquid Biopsy Platform to be Presented at Two Upcoming Medical Conferences 4
... studied the marine trophic network in Mauritania, on the ... heavily exploited fishing area, as well as being home ... marine mammal the monk seal and the Atlantic ... industrial and traditional fishing activities along the coast are ...
... -- NASA,s newest Earth-observing research mission is nearing launch. ... the sun and tiny atmospheric particles called aerosols affect ... long-term solar measurements needed to address key uncertainties about ... from Vandenberg Air Force Base in California on Feb. ...
... a hormone best known for stimulating the production of red ... published by Cell Press in the January 27th issue of ... contrasting influences on infectious and inflammatory diseases and may be ... is a cytokine hormone that stimulates the production of red ...
Cached Biology News:Monk seal and hump-backed dolphin are threatened by fishing activities off coast of Mauritania 2NASA prepares to launch next Earth-observing satellite mission 2NASA prepares to launch next Earth-observing satellite mission 3Red blood cell hormone modulates the immune system 2
(Date:6/26/2015)... /PRNewswire/ - iCo Therapeutics ("iCo" or "the Company") (TSX-V: ... listed in the management information circular dated June 1, ... Meeting of Shareholders, held earlier today, June 26 ... 5 nominees proposed by management were elected as ... Company,s next Annual Meeting of Shareholders or until ...
(Date:6/26/2015)... , June 23, 2015 ... announced the addition of the "Global Cancer ... offering. Market introduction of cancer biosimilar ... and commercialization potential. Chemotherapeutic drugs have dominated the ... modalities have been introduced in past few years. ...
(Date:6/25/2015)... 25, 2015 ... announced the addition of the  "2015 ... Cancer Diagnostics Industry: Oncogenes, Biochemical Markers, ... Commercial Labs, POC Locations"  report ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , A ...
(Date:6/25/2015)... NEW YORK , June 25, 2015  The ... , Professor of Genome Sciences and Medical Genetics at ... the 2015 Pro Bono Humanum Award at the ninth ... ceremony.   The Pro Bono ... Professor King is the first woman recipient of the ...
Breaking Biology Technology:iCo Therapeutics Announces Voting & Election Results from Annual Meeting of Shareholders 2iCo Therapeutics Announces Voting & Election Results from Annual Meeting of Shareholders 3Global Cancer Biosimilars Market Opportunity Outlook 2Global Cancer Biosimilars Market Opportunity Outlook 3Analysis of the Global Cancer Diagnostics Industry 2015-2020: Oncogenes, Biochemical Markers, Lymphokines, GFs, CSFs, Hormones, Immunohistochemical Stains 2Analysis of the Global Cancer Diagnostics Industry 2015-2020: Oncogenes, Biochemical Markers, Lymphokines, GFs, CSFs, Hormones, Immunohistochemical Stains 3The Prix Galien USA Awards Committee Selects Professor Mary-Claire King as 2015 Pro Bono Humanum Honoree 2The Prix Galien USA Awards Committee Selects Professor Mary-Claire King as 2015 Pro Bono Humanum Honoree 3
... (Pink Sheets: BIEL), announced today that the ... sale by its,distributor, Endotherapeutics Party Limited. ... professionals of,Endotherapeutics will successfully launch ActiPatch in ... of experience in the,medical devices market and ...
... ... REDWOOD CITY, Calif., Oct. 9 Ingenuity Systems, ... science researchers,generate insights from biological and chemical information, ... to help researchers understand metabolomics data in the,context ...
... Drug Pipeline and Advancement of Clinical Programs, ... Inc.,(OTC Bulletin Board: AVGO), a late-stage biotechnology company ... today that it will be a presenting company ... held October 9-11, 2007 at the,Palace Hotel of ...
Cached Biology Technology:Australian Therapeutics Goods Administration Approval for ActiPatch Achieved 2Ingenuity Systems Launches New Metabolomics Solution Within IPA 2Avicena to Present at 4th Annual BIO InvestorForum Conference 2
MAb to Myoglobin Cardiac...
... The SDSaway reagent is a valuable tool ... The presence of SDS in biological ... tightly bound SDS-protein complex, inhibits enzymatic activity ... presents as a contaminant in mass spectrometry ...
Cells are grown to a specified density and induced, when necessary. Protein expression samples are collected at 3 growth points and analyzed by SDS-PAGE/Coomassie....
NovaScreen offers cell biology, cell culture and molecular biology services for companies who lack a cell culture facility....
Biology Products: