Navigation Links
Why getting healthy can seem worse than getting sick
Date:3/20/2012

A new article in The Quarterly Review of Biology helps explain why the immune system often makes us worse while trying to make us well.

The research offers a new perspective on a component of the immune system known as the acute-phase response, a series of systemic changes in blood protein levels, metabolic function, and physiology that sometimes occurs when bacteria, viruses, or other pathogens invade the body. This response puts healthy cells and tissue under serious stress, and is actually the cause of many of the symptoms we associate with being sick.

"The question is why would these harmful components evolve," asks Edmund LeGrand (University of Tennessee, Knoxville), who wrote the paper titled with Joe Alcock (University of New Mexico). The researchers contend that answer becomes clear when we view the acute-phase response in terms of what they call "immune brinksmanship."

The immune brinksmanship model "is the gamble that systemic stressors will harm the pathogens relatively more than the host," LeGrand said. The concept, he explains, is akin to what happens in international trade disputes. When one country places trade sanctions on another, both countries' economies take a hit, but the sanctioning country is betting that its opponent will be hurt more.

"One of our contributions here is to pull together the reasons why pathogens suffer more from systemic stress," LeGrand said.

The acute-phase response creates stress in several ways. It raises body temperature and causes loss of appetite and mild anemia. At the same time, certain vital nutrients like iron, zinc, and manganese are partially sequestered away from the bloodstream.

Some of these components are quite puzzling. Why reduce food intake just when one would expect more energy would be needed to mount a strong immune response? Zinc is essential for healthy immune function. Why pull it out of the bloodstream when the immune system is act
'/>"/>

Contact: Kevin Stacey
kstacey@press.uchicago.edu
401-284-3878
University of Chicago Press Journals
Source:Eurekalert

Page: 1 2

Related biology news :

1. Getting cancer cells to swallow poison
2. Panama REDD: Getting what you pay for
3. Pregnant women in Vancouver may not be getting enough vitamin D
4. Getting 50-year-old Americans as healthy as Europeans could save Medicare and Medicaid $632 billion by 2050
5. Americans still may not be getting enough calcium
6. Getting closer to a better biocontrol for garden pests
7. Getting organized: Berkeley Lab study shows how breast cell communities organize into breast tissue
8. Getting rid of cattle fever ticks
9. Getting a tail up on conservation?
10. Warning system inadequate to prevent swimmers from getting sick at inland lakes
11. Getting a step ahead of pathogens
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... , June 27, 2014  Pomerantz LLP has ... Inc. ("Provectus" or the "Company")(NYSE-MKT: PVCT) and certain ... United States District Court, Middle District of ... behalf of a class consisting of all persons ... securities between December 17, 2013 and May 22, ...
(Date:7/10/2014)... 2014 NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication company focused ... Gino Pereira was interviewed on July 1 st ... Florida . Mr. Pereira discusses the company,s next generation ... and how the Wocket™ aims to replace a traditional wallet ... Cedric Harris tells Gino he has never heard of ...
(Date:7/10/2014)... July 8, 2014 Fingerprint ... new design win (DW). An Asian OEM has selected FPC1021 ... production start in August 2014.   FPC is ... which has a planned date for start of mass production ... order of SEK 5M, for delivery in the first half ...
Breaking Biology News(10 mins):SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 2Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 4FPC Wins DW and Initial Ramp Order for FPC1021 Touch Sensor for Flagship Smartphone from Asian OEM 2
... WI, JUNE 14, 2011 - Tropical maize proves to ... in USA Corn Belt maize. Most tropical maize varieties ... in U.S. growing regions by flowering late. This delayed ... useful genes and hindering their incorporation into maize hybrids ...
... our brain, and new research by University of California, ... that fear and other highly emotional experiences lead to ... (Tuesday, June 14) in advance of publication in the ... and colleagues report a new way for emotions to ...
... zone is predicted to be larger than average this ... this spring, according to an annual forecast by a ... Consortium, Louisiana State University and the University of Michigan. ... compiled annually by the U.S. Geological Survey (USGS). ...
Cached Biology News:Unique gene combinations control tropical maize response to day lengths 2Fear boosts activation of young, immature brain cells 2Fear boosts activation of young, immature brain cells 3Major flooding on the Mississippi River likely to cause large Gulf of Mexico dead zone 2Major flooding on the Mississippi River likely to cause large Gulf of Mexico dead zone 3
(Date:7/11/2014)... BCC Research ( http://www.bccresearch.com ) reveals in its new ... GLOBAL MARKETS , the global market for digital polymerase ... 2013. This is estimated to grow to $490 billion ... (CAGR) of 28.6%. , New digital PCR technology has ... the broader PCR field. The opportunities presented by this ...
(Date:7/11/2014)... , July 11, 2014  Researchers have ... three-dimensional images. The new technology, called Virtual Finger, ... small structures like neurons and synapses using the ... unique technology makes 3D imaging studies orders of ... at an unprecedented level across many areas of ...
(Date:7/10/2014)... Product and process impurities in ... and are often “lost in the noise,” making ... presenters Dr. Rowel Tobias, Senior Scientist, Protein Chemistry ... of Quality at Nanotherapeutics, Inc., to lear about ... detection and quantitation while achieving the required specificity ...
(Date:7/10/2014)... Terascala, the industry leader in HPC management ... vice president of product management for Flexera Software, has ... Terascala’s software when combined with leading compute and storage ... and most reliable solutions for processing big data. , ... and broaden its product portfolio. His leadership in startups ...
Breaking Biology Technology:Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 2Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 3Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Terascala Expands Executive Team 2Terascala Expands Executive Team 3
... SectorWatch.biz announces the,availability of MarketStats on public ... today., Investors can view all of SectorWatch.biz ... -- Click on MarketStats, Today,s MarketStats on ... (OTC Bulletin Board: CVBT), Boston,Scientific Corp. (NYSE: ...
... Innovations Inc.,(TSX: ATB) will hold its quarterly conference ... February 29, 2008. The call will follow the ... year results issued earlier that,day. Participants may access ... or 800-731-5774 or via the Company,s website at, ...
... 14 Accelerated Community Oncology,Research Network, Inc. ... Phase,2b clinical trial evaluating the efficacy of ... drug gemcitabine (Gemzar(R)) in patients,with metastatic breast ... after,treatment with bevacizumab (Avastin(R))., (Logo: ...
Cached Biology Technology:SectorWatch.biz Issues MarketStats on CVBT, BSX, MDT, CXM and DNA 2Atrium Innovations to Hold 2007 Fourth Quarter and Full-Year Financial Results Conference Call and Webcast on February 29 2Accelerated Community Oncology Research Network, Inc. (ACORN), Initiates a Phase 2b Metastatic Breast Cancer Trial in Cooperation With Bayer and Onyx 2Accelerated Community Oncology Research Network, Inc. (ACORN), Initiates a Phase 2b Metastatic Breast Cancer Trial in Cooperation With Bayer and Onyx 3
These 22x40mm rectangular No.1 Corning cover glasses are made from No. 0211 zinc titania glass and are 0.16 to 0.19mm thick. • Approx. Pcs Oz : 73...
The model 55D Rocking Shaker provides the same Reliable quality as the 55S, but double the value. The 55D gives you an additional platform with a height of 3.25 in....
... rolled steel with stove enamel coated (RAL 7035 ... Front, back and side windows ... lamps Internal adjustable tempered glass shelf ... Lighting 600 lux ...
... Shaker provides the exact agitation needed ... very slow to fast speed and ... a gentle wave motion that lifts ... membranes to achieve faster, more uniform ...
Biology Products: