Navigation Links
Why does anxiety target women more? FSU researcher awarded $1.8 million grant to find out
Date:9/1/2010

Anxiety disorders afflict women twice as often as men, but estrogen might not be the reason. Testosterone, though, could be.

That is one of the preliminary findings in the lab of Florida State University researcher Mohamed Kabbaj, associate professor in the College of Medicine. He recently was awarded a five-year, $1.8 million grant from the National Institute of Mental Health to investigate the sex differences in anxiety. His research team also is working to identify the role of a gene called zif268.

"It's a very important molecule," Kabbaj said. "So far, zif268 plays a major role in learning, memory and drug addiction. I think our work shows for the first time that it's also implicated in anxiety."

Years from now, the result may be drugs that can reduce anxiety more effectively.

In their lab, Kabbaj and his team exposed male and female rats to situations that provoked anxiety. They knew stress would activate the zif268 gene, so they explored the brains of the rats to see how the gene had expressed itself. Kabbaj called it "a fishing expedition."

The results surprised them. Only one part of the brain showed a difference in gene expression between males and females: the medial prefrontal cortex, the part of the brain that allows humans to experience emotions and the meaning of things.

"We were not expecting to see that," Kabbaj said, "so we wanted to follow up with functional studies to see if this difference between males and females has any significance in terms of anxiety and difference in social interaction."

Males have more zif268 in their prefrontal cortex than females do. Males also are less anxious. So the researchers reduced the expression of zif268 in the prefrontal cortex of the males. Result: The males became as anxious as the females.

"One of the questions you have to ask," Kabbaj said, "is why males have more zif than females. We think it's because of testosterone. Testoste
'/>"/>

Contact: Ron Hartung
ronald.hartung@med.fsu.edu
850-645-9205
Florida State University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Biological link between stress, anxiety and depression identified for the first time
2. Mental health providers should prescribe exercise more often for depression, anxiety
3. Depression and anxiety disorders of adolescents are not the same thing
4. The genetics of fear: Study suggests specific genetic variations contribute to anxiety disorders
5. Research targets basic metabolism of disease-causing fungi, bacteria
6. New mechanisms of tumor resistance to targeted therapy in lung cancer are discovered
7. Scientists reveal new targets for anti-angiogenesis drugs
8. A cellular housekeeper, and potential target of obesity drugs, caught in action
9. Scientists target possible cause of 1 form of bowel disease
10. Novel bee venom derivative forms a nanoparticle smart bomb to target cancer cells
11. Cancer-causing bacterium targets tumor-suppressor protein
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Why does anxiety target women more? FSU researcher awarded $1.8 million grant to find out
(Date:4/14/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market, announces that its Wocket® smart ... Design Awards under the category  ,Product Design – Technology,. ... are part of a global multi-disciplinary awards program. The ... marketplace, industry and judging panel. Winners will be announced ...
(Date:4/13/2015)... April 13, 2015  higi, a leading cloud-based consumer ... more fully engage with their communities around health and ... protected and secure API.  ... most accessible, affordable, and convenient vehicle to receive validated ... The API will allow higi,s trusted ...
(Date:4/9/2015)... April 9, 2015 Synaptics Inc. (NASDAQ: SYNA ... today that it will report financial results for the ... 2015, after the close of market. The company will ... at 2:00 p.m. PT (5:00 p.m. ET), during which ... participate on the live call, analysts and investors should ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3Synaptics to Report Third Quarter Results on April 23 2
... 2013)In a series of papers to be presented next ... mechanism operating in the roots of a tropical grass ... greenhouse gas emissions. Referred to as "biological nitrification ... of nitrogen applied to soil as fertilizer into nitrous ...
... This news release is available in German ... daughter; like father, like son. Evolutionary biologists at the universities in ... also applies to inheriting a long life at least for ... descendants of these insects mostly inherit their lifespan from their own ...
... disease indicate future joint problems? Although researchers and clinicians ... chronic inflammatory diseases - periodontal disease and rheumatoid arthritis ... In an article published today in PLOS Pathogens ... and Systemic Diseases group researcher Jan Potempa, PhD, DSc, ...
Cached Biology News:'Grassroots action' in livestock feeding to help curb global climate change 2'Grassroots action' in livestock feeding to help curb global climate change 3'Grassroots action' in livestock feeding to help curb global climate change 4Inheritance of lifespan is sex-dependent in fruit flies 2Bacteria responsible for gum disease facilitates rheumatoid arthritis 2
(Date:4/30/2015)... Kent, WA (PRWEB) April 30, 2015 ... recently developed ultrafiltration membranes, the PX, PY, ... test coupons, sheets, and disks. Designed to ... applications, these new membranes can fill critical process ... effluent hinder downstream processes. , “New regulations on ...
(Date:4/29/2015)... GUELPH, ON , April 29, 2015 /PRNewswire/ - BIOREM Inc. (TSX-V: BRM) ... twelve-month periods ended December 31, 2014. Biorem,s complete fiscal 2014 year-end financial ... FINANCIAL HIGHLIGHTS: 2014 , 2013 , 2014 ... 10,683 , 19,596 Gross profit 1,326 , ... 1,191 , 1,493 , 3,377 , ...
(Date:4/29/2015)... , April 29, 2015 ... of cartilage, cellular, bone, skin and soft-tissue allografts ... to advance patient healing, announced the launch of ... for Medicare & Medicaid Services (CMS) also moved ... the low-cost to the high-cost category for reimbursement. ...
(Date:4/29/2015)... April 29, 2015 /CNW/ - Northern Biologics Inc., a ... today announced an exclusive, strategic collaboration with Celgene ... received a US$30 million upfront cash payment. It ... first-in-class therapeutic antibodies, and will have the right ... advancement of its portfolio. Under ...
Breaking Biology Technology:Sterlitech Offers New Ultrafiltration Membranes 2Biorem Reports Results for Fourth Quarter 2014 and Year Ended December 31, 2014 2Biorem Reports Results for Fourth Quarter 2014 and Year Ended December 31, 2014 3Biorem Reports Results for Fourth Quarter 2014 and Year Ended December 31, 2014 4AlloSource Announces New Possibilities In Wound Care 2Northern Biologics and Celgene Enter Strategic Collaboration 2
... are generally complicated and therefore often rather difficult to ... report on new methods which not only produce outstanding ... starting materials but also do not need expensive instrumentation. ... This is exactly what Jamil Elias and ...
... Mylan Inc. (Nasdaq: MYL ) today announced that ... principal amount of senior notes through a reopening of its Senior ... are being offered as additional notes under an existing indenture under ... Senior Notes due 2020 on May 19, 2010 . The ...
... Kansas to its annual promotional campaign of biotechnological, pharmaceutical and medical device companies from ... , (Logo:   http://photos.prnewswire.com/prnh/20040907/CLTU006LOGO ... (Logo:   http://www.newscom.com/cgi-bin/prnh/20040907/CLTU006LOGO ) , ... The leading employment Web site for the life sciences launched the 2010 ...
Cached Biology Technology:Empa grows 'sea urchin'-shaped structures 2Mylan Announces Proposed Add-On Private Placement of its Senior Notes Due 2020 2Mylan Announces Proposed Add-On Private Placement of its Senior Notes Due 2020 3BioSpace Showcases the Midwest's Growing Life Science Region 2BioSpace Showcases the Midwest's Growing Life Science Region 3
...
... designed to rapidly and reliably amplify unknown ... Technology. APAgene provides hassle-free, ready-to use components, ... ingredients are provided in each kit. The ... for insert-end amplification of large clones such ...
Rabbit polyclonal to Yaf9 ( Abpromise for all tested applications)....
... product is designed to deparaffinize and perform ... fixed paraffin-embedded tissue sections mounted on glass ... the paraffin at the high temperature used ... emulsification of the paraffin by detergent. Formaldehyde ...
Biology Products: