Navigation Links
Why do preterm deliveries pose cardiovascular risks for moms?
Date:1/10/2011

EAST LANSING, Mich. As the rate of preterm delivery rises accounting for 12.5 percent of all U.S. births a Michigan State University epidemiologist is using a $3.7 million federal grant to uncover why some mothers who deliver babies early are at an increased risk of developing cardiovascular disease.

Finding those links would help researchers identify which groups of women may benefit from early tracking and intervention, said Claudia Holzman, an epidemiology professor in MSU's College of Human Medicine who is collaborating with Janet Catov of the University of Pittsburgh on the study.

"As a group, women who have delivered a preterm infant have an increased risk of developing cardiovascular disease, but the mechanisms responsible for that link are not understood," said Holzman, whose study is funded by the National Institutes of Health.

"We believe that pregnancy unmasks a predisposition to cardiovascular disease: Inflammation, an increase in lipids and the formation of blood clots during pregnancy may be related to preterm delivery and be indicators of later complications in some women who deliver preterm."

To research that hypothesis, Holzman and Catov will rely on the Pregnancy Outcomes and Community Health cohort, a group of more than 3,000 women enrolled in a study to examine the causes of preterm delivery. Holzman and colleagues began the POUCH study in 1998, and the cohort of women will be followed to study many different factors of preterm births in relation to the health of both children and mothers.

About 900 women (both who delivered preterm and those who did not) will be enrolled in the new study, Holzman said. The research team will study the cardiovascular profiles of women 6-11 years after they participated in the POUCH study, collecting data such as height, weight, waist circumference and blood pressure, as well as blood levels of inflammatory markers, lipids and factors leading to blood clots.

Holzman said the team then will compare the data of women who delivered full-term babies with women who delivered preterm; researchers also will examine whether any association may be modified by factors such as race, socioeconomic status or maternal depression.

"Research that uncovers pathways linking preterm delivery to a mother's cardiovascular risk can lead to new treatment strategies for both problems," Holzman said. "If we can identify mothers very early in the process, we may be able to delay or prevent the onset of cardiovascular disease."

The women in the original POUCH study were patients at 52 clinics in five Michigan communities; researchers collected biological samples in mid-trimester, including blood, saliva, urine, hair and vaginal fluid. The placentas also were examined for pathologic markers linked to preterm deliveries.

The women also underwent detailed interviews and answered questionnaires about their lifestyles, home situations, economic status and perceived discrimination.


'/>"/>

Contact: Jason Cody
codyja@msu.edu
517-432-0924
Michigan State University
Source:Eurekalert  

Related biology news :

1. Depression during pregnancy can double risk of preterm delivery
2. Uncultured bacteria found in amniotic fluids of women who experience preterm births
3. Preterm birth: Magnesium sulphate cuts cerebral palsy risk
4. Effectiveness of progesterone in reducing preterm births may be altered by genetic predisposition
5. March of Dimes provides $2.7 million in new funding for preterm birth research
6. HPV vaccine may prevent preterm births
7. Brain malformations significantly associated with preterm birth, Wake Forest research shows
8. Yale researchers may have uncovered the mechanism by which progesterone prevents preterm birth
9. New research shows genes of pregnant women and their fetuses can increase the risk of preterm labor
10. Prepregnancy, obesity and gestational weight gain influence risk of preterm birth
11. March of Dimes provides $2.6 million in new funding for preterm birth research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Why do preterm deliveries pose cardiovascular risks for moms?
(Date:1/22/2016)... , Jan. 22, 2016 ... addition of the "Global Biometrics Market ... their offering. --> http://www.researchandmarkets.com/research/p74whf/global_biometrics ... "Global Biometrics Market in Retail Sector ... --> Research and Markets ( ...
(Date:1/20/2016)... 20, 2016 A market that just keeps ... from the explosion in genomics knowledge. Learn all about ... A range of dynamic trends are pushing market growth ... medicine - pharmacogenomics - pathogen evolution - next generation ... - greater understanding of the role of genetic material ...
(Date:1/20/2016)... , Jan. 20, 2016  Synaptics Incorporated (NASDAQ: ... interface solutions, today announced sampling of S1423, its ... wearables and small screen applications including smartwatches, fitness ... Supporting round and rectangular shapes, as well as ... performance with moisture on screen, while wearing gloves, ...
Breaking Biology News(10 mins):
(Date:2/12/2016)... 12, 2016  BD (Becton, Dickinson and Company) (NYSE: ... today announced the launch of the BD CLiC™ System ... (AGBT) Meeting. --> ... by providing cost effective NGS library preparation with limited ... fully integrated, next generation sequencing (NGS) library prep instrument, ...
(Date:2/11/2016)... Non-profit Consortium Aims to Generate Genomic ... Research and Discovery --> --> ... plan to sequence 100,000 individuals. It is intended to initially ... 7 of North and East Asian countries. ... project will focus on creating phased reference genomes for all ...
(Date:2/11/2016)... HILDEN , Germany and ... QGEN ; Frankfurt Prime Standard: ... new QIAseq Targeted RNA Panels for gene expression profiling, ... next-generation sequencing (NGS). The panels enable researchers to select ... expression fold changes and discover interactions between genes, cellular ...
(Date:2/11/2016)... , Feb. 11, 2016  Wellcentive today announced ... Portland, Oregon -based community care organization ... population health analytics, quality reporting and care management ... strengthen its team of quality managers, analysts and ... the provider groups serving FamilyCare members. ...
Breaking Biology Technology: