Navigation Links
Why chemotherapy causes more infertility in women than in men
Date:2/22/2011

Chemotherapeutic agents, used in cancer treatment, destroy not only cancer cells but also healthy cells, thus affecting germ cells as well. Consequently, after surviving cancer many female patients are confronted with the diagnosis: infertility. For a long time a relationship between infertility and chemotherapeutic agents has been assumed, but until now, the exact mechanism was not known.

Scientists from the research group of Prof. Volker Dtsch (Institute of Biophysical Chemistry, Goethe University Frankfurt) in cooperation with international partners have now started to unveil the mechanism of cancer treatment related infertility. Their results are published in the internationally renowned journal Cell. Mainly women suffer from infertility because the quality control in the oocytes is different from male germ cells. Male germ cells are produced throughout the whole life span but the number of female germ cells is restricted and already fixed before birth. If the oocytes are damaged during cancer treatment, they are destroyed by the female quality control mechanism.

Essential for this process is the protein p63 which shows striking similarity to another important protein of the same family: p53. p53 is also named "guardian of the genome" because of its regulatory function in cell division and cell death of damaged cells and, therefore, plays a key role in the suppression of genetic anomalies which could lead to cancer. In more than half of all human tumors p53 is altered and no longer functional.

For a long time the exact regulation of p53 and p63 and the similarities and differences between these two proteins have been the object of many international research projects. In the currently accepted model the concentration of p53 in healthy cells is relatively low. If genetic anomalies occur in a cell which could cause the transition to a cancer cell, the concentration of p53 increases and four p53 proteins form a tetramer. In this tetrameri
'/>"/>

Contact: Prof. Volker Doetsch
vdoetsch@em.uni-frankfurt.de
49-697-982-9631
Goethe University Frankfurt
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. A loose grip provides better chemotherapy
2. Invention could improve cancer drug delivery, lessen harmful effects of chemotherapy
3. Virginia Tech engineers introduce thermotherapy as a chemotherapy alternative
4. Major component in turmeric enhance effect of chemotherapy drug in head and neck cancer
5. Novocure reports data showing TTF therapy in combination with chemotherapy has the potential to increase overall survival for patients with advanced non-small cell lung cancer
6. Identifying subsets of patients who will respond to subsequent lines of chemotherapy
7. New technology may prolong the life of implanted devices, from pacemakers to chemotherapy ports
8. TGen finds protein inhibitor revives chemotherapy for ovarian patients
9. Duke develops nano-scale drug delivery for chemotherapy
10. Common chemotherapy drug triggers fatal allergic reactions
11. CSHL team develops mouse models of leukemia that predict response to chemotherapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2013)... study reports that white men and women of European ... valgus) and lesser toe deformities, including hammer or claw ... estimate the heritability of foot disorders in humansappear in ... by Wiley on behalf of the American College of ... many as 60% of older adults have foot disorders ...
(Date:5/18/2013)... today at Digestive Disease Week (DDW) explores new discoveries ... of coffee on autoimmune disease and palliative care for ... been associated with reduced risk of fibrosis, a new ... java each month also correlate with lower risk for ... Clinic, Rochester, MN, linked coffee consumption with reduced risk ...
(Date:5/17/2013)... South, but the night belongs to the amphibians. In ... humidity and the sounds of wildlife. , The Southeast, ... salamanders, is the center of amphibian biodiversity in our nation. ... their symphonic choruses, the scientists of the U.S. Geological Survey,s ... , Amphibians, which rely on water for part ...
Breaking Biology News(10 mins):Blame your parents for bunion woes 2Coffee consumption associated with reduced risk of autoimmune liver disease 2Front-row seats to climate change 2Front-row seats to climate change 3Front-row seats to climate change 4
... soon be able to wear contact lenses that continuously ... changing colours replacing the need to routinely draw ... by Chemical and Biochemical Engineering professor Jin Zhang at ... embedded into the hydrogel lenses. These engineered nanoparticles ...
... the deoxycytidine kinase (dCK) enzyme have defects in their ... T and B lymphocytes, the major players involved in ... UCLA,s Jonsson Comprehensive Cancer Center. The finding could ... body attacks itself, and possibly certain cancers of the ...
... common minerals in biology, including those in bones and shells, have ... making them behave as one giant crystal, even though they do ... grains of salt were spilled on a rug, yet instead of ... rotation. In a new study in the Journal ...
Cached Biology News:Enzyme necessary for development of healthy immune system 2Enzyme necessary for development of healthy immune system 3Dental delight: Tooth of sea urchin shows formation of biominerals 2Dental delight: Tooth of sea urchin shows formation of biominerals 3
(Date:5/20/2013)... Biomarkers and Clinigene International are set to unveil their ... 2013 AAPS/ National Biotechnology Conference May 20-22 ... Marina , San Diego, CA. ... company representatives at their collaborative seminar, "Biosimilarity, Immunogenicity and ... 1-2 p.m. in the conference,s Spinnaker Room. ...
(Date:5/20/2013)... HILL, N.C. , May 20, 2013 /PRNewswire/ ... company focused on developing differentiated antibiotics to meet ... infections, today announced that it presented data at ... in Philadelphia demonstrating the ... levofloxacin in Cempra,s prior Phase 2 clinical trial ...
(Date:5/20/2013)... Interventional cardiologist Tony Farah, MD, and his ... Cardiovascular Institute have helped pioneer many breakthroughs in ... over the past three decades, from new disease-fighting medications ... artery stent implantation. , Today, AGH officials announced that ... in the study of a novel, first-of-its kind investigational ...
(Date:5/20/2013)... 2013 On 25-28 July, 2013, UPCP ... Paris - the beautiful city of lights. , According ... is revolutionizing the medical world. Understanding and integrating genetic ... hallmark of this transformation. Much of the present medical ... epidemiologic studies of large cohorts that do not take ...
Breaking Biology Technology:Pacific Biomarkers and Clinigene International To Announce Laboratory Solutions for Developers of Biosimilars at 2013 AAPS/ National Biotechnology Conference 2Cempra Presents Post-Phase 2 Analysis of Solithromycin's Efficacy and Safety Results from Patients with Community Acquired Bacterial Pneumonia (CABP) 2Allegheny General Hospital Cardiovascular Institute Becomes Exclusive Pittsburgh Site for Study of Novel Coronary Artery Disease Device 2Allegheny General Hospital Cardiovascular Institute Becomes Exclusive Pittsburgh Site for Study of Novel Coronary Artery Disease Device 3Allegheny General Hospital Cardiovascular Institute Becomes Exclusive Pittsburgh Site for Study of Novel Coronary Artery Disease Device 4The International Congress on Personalized Medicine - Up Close and Personalized 2013 in Paris 2
... , May 18, 2010 , , ... - With Photo , , , ... safety device is now cleared by FDA for Home/Self use and is,consequently available to all ... dislodgement,during hemodialysis and its use has already improved in-clinic patient,safety. Optimizing safety conditions for home ...
... ... highly specialized metal tubing and innovative suppliers with ultra-fine finishing capabilities , ... (PRWEB) -- The increased miniaturization ... off in many ways. One of the integral items that have helped to ...
... , ... METTLER TOLEDO announced a collaboration to combine their existing technologies to offer flow reactor ... production. , ... (PRWEB) -- ThalesNano and METTLER TOLEDO announced a partnership to offer flow reactor technology ...
Cached Biology Technology:Redsense Medical Receives FDA Clearance for the Redsense Safety Device for Home/Self use During Home Hemodialysis 2Ultra-Fine Metal Tubing Smoothes the Way for Miniaturized Medical Devices 2Ultra-Fine Metal Tubing Smoothes the Way for Miniaturized Medical Devices 3METTLER TOLEDO and ThalesNano Bring Real-time Reaction Monitoring to Flow Synthesis 2METTLER TOLEDO and ThalesNano Bring Real-time Reaction Monitoring to Flow Synthesis 3METTLER TOLEDO and ThalesNano Bring Real-time Reaction Monitoring to Flow Synthesis 4
...
...
BD BioCoat Laminin 60 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of mouse laminin....
... BD BioCoat Collagen I 60 mm Culture Dishes ... Dishes, tissue-culture treated polystyrene with a uniform application ... Coating : Collagen I ,Surface : ... 21.3 cm2 ,Dim nominal : 60 ...
Biology Products: