Researchers focused on genes responsible for bone health. They found that alcohol affected the amounts of RNA associated with these genes. (RNA serves as the template for making proteins, the building blocks of bones and other tissue.) With some genes, alcohol increased the amount of RNA. With other genes, alcohol decreased the RNA. Changing the amounts of RNA disrupted two molecular pathways responsible for normal bone metabolism and maintenance of bone mass. These pathways are called the Wnt signaling pathway and the Intergrin signaling pathway.
"We found that the expressions of certain genes important for maintaining bone integrity are disturbed by alcohol exposure," Callaci said.
Loyola scientists and doctors are conducting extensive research on the effects of alcohol. Researchers are, for example, studying how alcohol causes memory loss and impairs the immune system.
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| Contact: Jim Ritter jritter@lumc.edu 708-216-2445 Loyola University Health System Source:Eurekalert |