Navigation Links
Why binge drinking is bad for your bones
Date:10/23/2008

MAYWOOD, Il. -- Studies in recent years have demonstrated that binge drinking can decrease bone mass and bone strength, increasing the risk of osteoporosis.

Now a Loyola University Stritch School of Medicine study has found a possible mechanism: Alcohol disturbs genes necessary for maintaining healthy bones.

The findings could help in the development of new drugs to minimize bone loss in alcohol abusers. Such drugs also might help people who don't abuse alcohol but are at risk for osteoporosis.

"Of course, the best way to prevent alcohol-induced bone loss is to not drink or to drink moderately," said bone biologist John Callaci, PhD. "But when prevention doesn't work, we need other strategies to limit the damage."

Callaci is co-author of the study, published recently in the journal Alcoholism: Clinical and Experimental Research. He is an assistant professor in Stritch's Department of Orthopaedic Surgery and Rehabilitation.

Callaci's co-authors are Frederick Wezeman, PhD, professor in the Department of Orthopaedic Surgery and Rehabilitation and Ryan Himes, a research assistant in the Burn and Shock Trauma Institute.

The National Osteoporosis Foundation says that many people who abuse alcohol do not get enough calcium. Alcohol also can affect the body's calcium supply. And drinking too much can increase the risk of falls and broken bones. The foundation advises drinking no more than two drinks per day.

Loyola's Alcohol Research Program was among the first centers to demonstrate that rats given an amount of alcohol equivalent to binge drinking show significant decreases in bone mineral density and bone strength. (In humans, binge drinking is defined as a woman having at least four drinks or a man having at least five drinks in two hours.) But surprisingly little was known about the mechanisms responsible for these effects.

In the new study, researchers injected rats with an amount of alcohol equivalent to binge drinking for three days or to chronic alcohol abuse for four weeks. Control groups received injections of saline.

Researchers focused on genes responsible for bone health. They found that alcohol affected the amounts of RNA associated with these genes. (RNA serves as the template for making proteins, the building blocks of bones and other tissue.) With some genes, alcohol increased the amount of RNA. With other genes, alcohol decreased the RNA. Changing the amounts of RNA disrupted two molecular pathways responsible for normal bone metabolism and maintenance of bone mass. These pathways are called the Wnt signaling pathway and the Intergrin signaling pathway.

"We found that the expressions of certain genes important for maintaining bone integrity are disturbed by alcohol exposure," Callaci said.

Loyola scientists and doctors are conducting extensive research on the effects of alcohol. Researchers are, for example, studying how alcohol causes memory loss and impairs the immune system.


'/>"/>

Contact: Jim Ritter
jritter@lumc.edu
708-216-2445
Loyola University Health System
Source:Eurekalert

Related biology news :

1. Alcohol binges early in pregnancy increase risk of infant oral clefts
2. Climate change could diminish drinking water more than expected
3. Drinking milk may help ease the pressure
4. Pediatricians alerted to the developmental nature of underage drinking in special journal supplement
5. Global Challenges/Chemistry Solutions debuts with focus on drinking water
6. Drinking water in Gaza Strip contaminated with high levels of nitrate
7. To your health: EPA announces safe drinking water research
8. New research on structure of bones raises questions for treatment of osteoporosis
9. Ancient fish bones reveal impacts of global warming beneath the sea
10. Where and why humans made skates out of animal bones
11. Excavated Jericho bones may help Israeli-Palestinian-German team combat tuberculosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/7/2017)... , Feb. 7, 2017   MedNet Solutions , ... entire spectrum of clinical research, is pleased to announce ... , its innovative, highly flexible and award winning eClinical ... customers. iMedNet is a proven Software-as-a-Service (SaaS) ... Data Capture (EDC), but also delivers an entire suite ...
(Date:2/6/2017)... , Feb. 6, 2017 According ... security are driving border authorities to continue to ... reports there are 2143 Automated Border Control (ABC) ... currently deployed at more than 163 ports of ... 2013 to 2016 achieving a combined CAGR of ...
(Date:2/2/2017)... JACKSONVILLE, Fla. , Feb. 2, 2017 /PRNewswire/ ... ), a clinical-stage immuno-oncology company specializing in the ... vaccines for the treatment of cancer and metastatic ... multi-gram scale-up and GMP manufacturing of a second ... T-cell vaccine targeting folate receptor alpha. The manufactured ...
Breaking Biology News(10 mins):
(Date:2/24/2017)... CA (PRWEB) , ... February 24, 2017 , ... Delpor, ... a $224K grant from the National Institute of Mental Health (NIMH) for the further ... on Delpor’s PROZOR technology and is expected to deliver therapeutic levels of ...
(Date:2/24/2017)... -- Symic Bio, a biopharmaceutical company focused on matrix ... announced today the completion of enrollment for the SHIELD ... trial will evaluate the safety and efficacy of SB-030, ... restenosis following angioplasty. "We,re pleased to ... Nathan Bachtell , M.D., Chief Medical Officer of ...
(Date:2/24/2017)... 2017 China Biologic Products, Inc. (NASDAQ: CBPO) ("China ... company in China, today announced its financial results for the ... Fourth Quarter 2016 Financial Highlights Total ... in RMB terms, or increased by 13.6% in USD terms ... of 2015. Gross profit increased by 13.3% ...
(Date:2/23/2017)... 2017 ... share data, unaudited)Three Months Ended December 31,Twelve Months Ended ... $           ... 89026%Aldurazyme Net Product Revenue 3539(10)%9498(4)%Kuvan ... Product Revenue  756025%297303(2)%Vimizim Net Product ...
Breaking Biology Technology: