Navigation Links
Why are some cells more cancer prone?

Baltimore, MDCells in the body wear down over time and die. In many organs, like the small intestine, adult stem cells play a vital role in maintaining function by replacing old cells with new ones. Learning about the nature of tissue stem cells can help scientists understand exactly how our organs are built, and why some organs generate cancer frequently, but others only rarely.

New work from Carnegie's Alexis Marianes and Allan Spradling used some of the most experimentally accessible tissue stem cells, the adult stem cells in the midsection of the fruit fly gut, with surprising results. Their findings are published by eLife.

Like the small intestine in mammals, the midgut of fruit flies is where most digestion takes place. Scientists had noticed a few regions in both the midgut and small intestine were specialized for certain tasks, such as absorbing iron, but had little understanding of the extent of these regional differences or how they were maintained.

Marianes and Spradling were able to demonstrate that there are 10 different major subregions within the fruit fly midgut. They occur in a specific order and each is responsible for different digestive and nutrient-storage processes, as evidenced by the expression of many specific genes. Most importantly, the adult stem cells in each region are specialized as well, and only support the types of cells found within it. Thus, during development, achieving the right spatial sequence of stem cells is probably critical to causing intestines to be built and maintained in order to function optimally.

The researchers also showed that tumors arise preferentially in specific regions of the midgut, a phenomenon well known in oncology. They showed the tumor-prone regions were specialized for lipid absorption, and stem cell function in them differed in small ways from stem cell function in other regions.

This work will motivate the search for fine-grained specialization in both tissue organization and in stem cells within many mammalian tissues. These subtle differences may explain the surprising results that are sometimes obtained following the removal or transplantation of human tissue. This must be considered carefully in ongoing attempts to utilize stem cells therapeutically.

Finally, it may be possible to learn what makes some stem cells more susceptible to cancer than others, and develop strategies to counteract this tendency.


Contact: Allan Spradling
Carnegie Institution

Related biology news :

1. Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
2. Stem cells can repair a damaged cornea
3. Scientists produce eye structures from human blood-derived stem cells
4. Study demonstrates cells can acquire new functions through transcriptional regulatory network
5. Epigenetic signatures direct the repair potential of reprogrammed cells
6. Researchers print live cells with a standard inkjet printer
7. Nanopills release drugs directly from the inside of cells
8. Protein jailbreak helps breast cancer cells live
9. Newly found protein helps cells build tissues
10. BU researchers derive purified lung and thyroid progenitors from embryonic stem cells
11. Housekeeping mechanism for brain stem cells discovered
Post Your Comments:
(Date:10/29/2015)... , Oct. 29, 2015 Daon, a ... that it has released a new version of its ... in North America have already ... v4.0 also includes a FIDO UAF certified server ... already preparing to activate FIDO features. These customers include ...
(Date:10/29/2015)... Oct. 29, 2015  Connected health pioneer, Joseph ... explosion of technology-enabled health and wellness, and the business ... The Internet of Healthy Things . ... smartphones even existed, Dr. Kvedar, vice president, Connected Health, ... care delivery, moving care from the hospital or doctor,s ...
(Date:10/29/2015)... Oct. 29, 2015 Today, LifeBEAM ... partnership with 2XU, a global leader in technical ... smart hat with advanced bio-sensing technology. The hat ... to monitor key biometrics to improve overall training ... the two companies will bring together the most advanced ...
Breaking Biology News(10 mins):
(Date:11/25/2015)...  Neurocrine Biosciences, Inc. (Nasdaq: NBIX ) announced ... of Neurocrine Biosciences, will be presenting at the 27th ... York . .   ... minutes prior to the presentation to download or install ... be available on the website approximately one hour after ...
(Date:11/25/2015)... San Francisco, CA (PRWEB) , ... November 25, ... ... leading microbial genomics company uBiome, were featured on AngelList early in their initial ... by launching an AngelList syndicate for individuals looking to make early stage investments ...
(Date:11/24/2015)... , Nov. 24, 2015 /CNW/ - iCo Therapeutics ... today reported financial results for the quarter ended ... expressed in Canadian dollars and presented under International ... United States ," said Andrew Rae ... advancements regarding iCo-008 are not only value enriching ...
(Date:11/24/2015)... --> --> ... Synthesis Market by Product & Services (Primer, Probe, Custom ... RNAi), End-User (Research, Pharmaceutical & Biotech, Diagnostic Labs) - ... is expected to reach USD 1,918.6 Million by 2020 ... of 10.1% during the forecast period. Browse ...
Breaking Biology Technology: