Navigation Links
Why are men more susceptible to alcoholism?
Date:10/18/2010

Philadelphia, PA, 18 October 2010 - Alcohol is one of the most commonly abused substances, and men are up to twice as likely to develop alcoholism as women. Until now, the underlying biology contributing to this difference in vulnerability has remained unclear.

A new study published in Biological Psychiatry reveals that dopamine may be an important factor.

Researchers from Columbia and Yale studied male and female college-age social drinkers in a laboratory test of alcohol consumption. After consuming an alcoholic or non-alcoholic drink, each participant underwent a specialized positron emission tomography (PET) scan, an imaging technique that can measure the amount of alcohol-induced dopamine release.

Dopamine has multiple functions in the brain, but is important in this context because of its pleasurable effects when it is released by rewarding experiences, such as sex or drugs.

Despite similar consumptions of alcohol, the men had greater dopamine release than women. This increase was found in the ventral striatum, an area in the brain strongly associated with pleasure, reinforcement and addiction formation.

"In men, increased dopamine release also had a stronger association with subjective positive effects of alcohol intoxication," explained Dr. Nina Urban, corresponding author for this study. "This may contribute to the initial reinforcing properties of alcohol and the risk for habit formation."

Dr. Anissa Abi-Dargham, senior author on this project, notes that "another important observation from this study is the decline in alcohol-induced dopamine release with repeated heavy drinking episodes. This may be one of the hallmarks of developing tolerance or transitioning into habit."

These findings indicate that the ability of alcohol to stimulate dopamine release may play an important and complex role in its rewarding effects and abuse liability in humans. This identification of an in vivo neurochemical mechanism that
'/>"/>

Contact: Chris J. Pfister
C.Pfister@elsevier.com
215-239-3266
Elsevier
Source:Eurekalert

Page: 1 2

Related biology news :

1. Athletes face tough hits, players susceptible to concussions
2. Genetic differences that make some people susceptible to meningitis revealed in major new study
3. Autism genome project identifies genetic variants that may make people susceptible to disorder
4. Genome comparison tools found to be susceptible to slip-ups
5. Harvard scientists solve mystery about why HIV patients are more susceptible to TB infection
6. Disabled and other vulnerable groups more susceptible to terrorism fears
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... The University of Chicago is creating a new ... at the University,s Institute for Molecular Engineering and ... million donation from the Millicent and Eugene Bell ... will reside within the Institute for Molecular Engineering. ... research project at the MBL,s Eugene Bell Center ...
(Date:7/11/2014)... Salk Institute for Biological Studies, BGI, and other ... and reliability of the existing targeted gene correction ... which could significantly increased gene-correction efficiency in human ... online in Cell Stell Cell provides ... therapy. , The combination of stem cells and ...
(Date:7/11/2014)... July 11, 2014 The increased risk of kidney ... in resuscitation fluids reflects the mass of HES molecules, ... , official journal of the International Anesthesia Research Society ... the harmful effect of HES on cultured human renal ... Dr Christian Wunder and colleagues of University Hospital Wrzburg, ...
Breaking Biology News(10 mins):New professorship in tissue engineering links molecular engineering, marine biology 2A new genome editing method brings the possibility of gene therapies closer to reality 2In lab studies, hydroxyethyl starch has direct harmful effects on kidney cells 2
... The first analysis of the healthful antioxidant content ... South America concludes that some of these fruits have ... renowned as "super fruits" sold throughout the United ... protection against heart disease, cancer and other conditions, the ...
... not rely on oxygen may have played an important role ... a theory that UChicago researcher Albert Colman is testing in ... He has found that bacteria at the site produce ... scientists must take into account as they attempt to reconstruct ...
... Planes were grounded all over Europe when the Eyjafjallajkull volcano erupted ... fly zone was really necessary. And the only way to find ... cloud - a potentially fatal experiment. , Now a team ... Iceland have developed a protocol for rapidly providing air traffic authorities ...
Cached Biology News:Cold case: Siberian hot springs reveal ancient ecology 2Cold case: Siberian hot springs reveal ancient ecology 3Novel ash analysis validates volcano no-fly zones 2
(Date:7/10/2014)... 10, 2014 Understanding the need for ... lines, and the gap that currently exists in this ... its industry-leading portfolio of validated ion channel and GPCR ... cell lines, as ion channels control many critical physiological ... activity creates the potential to treat a variety of ...
(Date:7/10/2014)... Los Angeles, CA (PRWEB) July 10, 2014 ... Analytical and Bioanalytical techniques during 18-20 August, 2014 at ... to critically review the recent developments in Analytical & ... across the globe. , Speaking on this occasion, Dr. ... that Analytica Acta conference is a remarkable one ...
(Date:7/10/2014)... July 10, 2014 On July ... Medvedev , presented Russia,s first ... . The Company is developing a unique project called ... BIOCAD develops a number of innovative drugs based on ... The ceremony took place at the International Exhibition "Innoprom ...
(Date:7/10/2014)...   Ceres, Inc . (Nasdaq: CERE ... financial results for the three months ended May 31, ... Ceres reported that the company and its customers ... season in Brazil, which concluded in June, despite dry ... areas for part of the growing season. Yields of ...
Breaking Biology Technology:Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9
... are today,s highlights from the AACE Annual Meeting & Clinical Congress in Boston : ... (Logo: http://www.newscom.com/cgi-bin/prnh/20090324/DC88061LOGO-b ) , ... Research Shows First-of-Its-Kind Hydrogel Decreases Obese Patients, Desire for Food   , ... New research indicates that a first-of-its-kind, superabsorbent hydrogel significantly increased the post-meal ...
... NEW YORK and SCOTTSDALE, Ariz. , ... Amex: NBS ), an international biopharmaceutical,company with operations ... BioSciences,Inc., a wholly owned subsidiary of IR BioSciences Holdings, ... entered into a,Collaborative Research Agreement, focused on the development ...
... ... Biotechnology Companies , ... Rochester, New York (PRWEB) April 22, 2010 -- iCardiac Technologies, Inc., a provider of ... has awarded iCardiac a cardiac safety study leveraging iCardiac’s COMPAS technology platform including advanced ...
Cached Biology Technology:Thursday News Highlights from the American Association of Clinical Endocrinologists (AACE) 19th Annual Meeting and Clinical Congress 2Thursday News Highlights from the American Association of Clinical Endocrinologists (AACE) 19th Annual Meeting and Clinical Congress 3NeoStem, Inc. and ImmuneRegen BioSciences(R) Announce a Collaborative Agreement to Advance Stem Cell Technology 2NeoStem, Inc. and ImmuneRegen BioSciences(R) Announce a Collaborative Agreement to Advance Stem Cell Technology 3NeoStem, Inc. and ImmuneRegen BioSciences(R) Announce a Collaborative Agreement to Advance Stem Cell Technology 4NeoStem, Inc. and ImmuneRegen BioSciences(R) Announce a Collaborative Agreement to Advance Stem Cell Technology 5NeoStem, Inc. and ImmuneRegen BioSciences(R) Announce a Collaborative Agreement to Advance Stem Cell Technology 6NeoStem, Inc. and ImmuneRegen BioSciences(R) Announce a Collaborative Agreement to Advance Stem Cell Technology 7Another Top 10 Pharmaceutical Company Awards Cardiac Safety Study to iCardiac 2
...
...
... Anti-β-Tubulin IV Recognizes an epitope ... of β-tubulin isotype IV. No ... is observed. ascites fluid synthetic ... sequence of β-tubulin isotype IV, ...
... Finnpipette BioControl is a major step ... complete liquid handling system - with ... tip cone modules. All five single ... modules fit one handle. The lightweight ...
Biology Products: