Navigation Links
Why a hereditary anemia is caused by genetic mutation in mechanically sensitive ion channel
Date:3/8/2013

. The increased stress caused by this loss of reinforcement causes the channels to open and the leak of calcium is likely what causes the muscles to atrophy, Sachs explains.

Sachs and colleagues at UB founded a biotech company in Buffalo, Tonus Therapeutics to create a therapy for muscular dystrophy based on a peptide they discovered that inhibits the channels involved in that disease. They originally discovered the peptide in a tarantula venom but now it is synthesized chemically. The peptide has received orphan drug designation from the FDA.

"We were pleased to find that our spider venom peptide also inhibits the PIEZO1 channel," says Sachs.

"This means our peptide could be a potential therapy in blood diseases, where there are defects in the ways that red blood cells regulate cell volume," he says.

In normal cells, he says, the mechanosensitive ion channels usually remain closed.

"I think the cells use them as emergency valves so the only time they open is when cells are under extreme stress," he explains. "Consequently, our peptide doesn't bother healthy cells, so it's nontoxic. It only affects unhealthy cells, cells which are mechanically stressed."


'/>"/>

Contact: Ellen Goldbaum
goldbaum@buffalo.edu
716-645-4605
University at Buffalo
Source:Eurekalert

Page: 1 2

Related biology news :

1. Nature study reveals loss of essential blood cell gene leads to anemia
2. Dinosaur bends caused by prolonged diving
3. Insecticide resistance caused by recombination of 2 genes
4. Einstein researcher receives $10.8 million grant to study toxic blood reactions caused by hemoglobin
5. Tsunami caused long-term ecosystem change in the Caribbean
6. Evidence contradicts idea that starvation caused saber-tooth cat extinction
7. A neurosteroid found to prevent brain injury caused by HIV/AIDS
8. Nearby chimpanzee populations show much greater genetic diversity than distant human populations
9. Will a genetic mutation cause trouble? Ask Spliceman
10. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
11. Perception and preference may have genetic link to obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... , March 24, 2015   Crossmatch ... solutions, today announced that its U.are.U ® ... retailer Goorin Bros . to achieve PCI ... solution secures access to the POS terminal, protecting ... risk of data breaches. With ...
(Date:3/23/2015)... March 23, 2015  In the 2014 fiscal year, ... conviction losses. This figure accounts for a fraction of ... The Nilson Report, exceeds $11 billion globally. The polygraph ... a crime has occurred. Investor Mark Saint Juste ... Joe Paolella partnered to administer the test ...
(Date:3/20/2015)... Mar. 19, 2015 Research and Markets ( ... Geometry - Global Strategic Business Report" report to their ... Hand Geometry in US$ Thousands. The report provides separate comprehensive ... Japan , Europe , ... and Rest of World. Annual estimates and forecasts ...
Breaking Biology News(10 mins):Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4
... life--is exploding as scientists worldwide discover the roles of ... organisms. The rapidly growing body of knowledge has created ... and system for describing, cataloging and comparing their findings. ... the RNA Ontology Consortium, has now been formed to ...
... The Institute of Bioengineering and Nanotechnology (IBN) has developed ... morphology of nanoparticles, which can be used in pharmaceutical ... was recently featured in the leading Chemistry journal, Angewandte ... on the invention. , Research Scientist Dr. Yu Han ...
... today released an automated literature search tool for ... is available as a free plug-in to Cytoscape ... to form a visual map of complex biological ... the biological causes of disease. , The Agilent ...
Cached Biology News:RNA project to create language for scientists worldwide 2RNA project to create language for scientists worldwide 3Breakthrough method in nanoparticle synthesis paves the way for new pharmaceutical and biomedical applications 2Agilent Technologies releases automated literature search tool for biology researchers 2Agilent Technologies releases automated literature search tool for biology researchers 3
(Date:4/16/2015)... April 16, 2015 Cytokinetics, Incorporated (Nasdaq: ... first quarter results on Thursday, April 30, 2015 at ... management will host a conference call at 4:30 PM ... the company’s outlook for the future. , The conference ... from the homepage and in the Investor Relations section ...
(Date:4/16/2015)... 16, 2015  Schulman Associates IRB, Inc., the industry-leading ... a long-term lease on Laboratory Drive in the heart ... . The location will house review board and service ... quality reviews and customer service to clients. ... Schulman in the deal, while Capital Associates Management, LLC ...
(Date:4/16/2015)... OncoTAb, Inc., a ... spin-out company, announced today the appointment of physician ... Chief Operating Officer (COO). Cooper brings to OncoTAb ... clinical diagnostic and biotechnology platforms in the fields ... extensive career transcends the field of medical and ...
(Date:4/16/2015)... - Portage Biotech Inc. ("Portage" or "the Company" )) ... to announce that the Company will be presenting  at ... be held in London, UK . ... James Mellon , a director of Portage, will ... programs at its subsidiaries, Portage Pharmaceuticals Ltd. ("PPL"), and ...
Breaking Biology Technology:Cytokinetics to Announce First Quarter Results on April 30, 2015 2Cytokinetics to Announce First Quarter Results on April 30, 2015 3Schulman IRB to Open Office in Research Triangle Park, N.C. 2OncoTAb Names Dr. David L. Cooper as COO 2Portage to Present at Master Investor 2015 in London, UK 2Portage to Present at Master Investor 2015 in London, UK 3Portage to Present at Master Investor 2015 in London, UK 4
... research at the University of Pennsylvania demonstrates that ... nanoscale semiconductors. This represents a promising advance in ... that use light rather than electricity. The ... postdoctoral fellow Lambert van Vugt and graduate student ...
... Solid grounding in science is widely considered to be ... biochemists and pharmacists to physician assistants and physical therapists, ... in the fields of healthcare and science. Yet, for ... Harris Interactive for University of the Sciences ...
... 15, 2011 PharmAthene, Inc. (NYSE Amex: ... biological and chemical threats, announced today that it has ... proceeds for the Company of approximately $6.5 million. ... sold an aggregate of 1,857,143 units to certain institutional ...
Cached Biology Technology:Penn researchers break light-matter coupling strength limit in nanoscale semiconductors 2Penn researchers break light-matter coupling strength limit in nanoscale semiconductors 3Careers in Healthcare and Science? "Not Interested" Say Half of U.S. Teens 2Careers in Healthcare and Science? "Not Interested" Say Half of U.S. Teens 3Careers in Healthcare and Science? "Not Interested" Say Half of U.S. Teens 4PharmAthene Completes $6.5 Million Registered Direct Offering 2PharmAthene Completes $6.5 Million Registered Direct Offering 3
SYBR Green Nucleic Acid Dye...
... from an inert polymer with a unique split ... split septum caps for use with 384-well tall-chimney ... when used in conjunction with screw or clip-down ... pipetting equipment 384 septum caps may be ...
... system . The sensitive conductivity detector CE ... houses the measuring cell in a thermostatted environment. ... Data processing is provided by the CE ... the high pressure CE 4100 dual piston pump. ...
Sufficient reagents for 50 applications.Mitochondria Isolation Kit Reagent A, 50 ml Mitochondria Isolation Kit Reagent B, 500 l Mitochondria Isolation Kit Reagent C, 70 ml...
Biology Products: