Navigation Links
Why a common treatment for prostate cancer ultimately fails
Date:8/21/2008

port cells known as stromal cells stimulates growth of cells, including cancer cells, in the prostate. He also found, surprisingly, that the receptor actually acts as a tumor suppressor in epithelial cells known as basal cells in the prostate.

Then Chang's team knocked out the androgen receptor in specific sets of prostate cells and studied the results. As expected, when the molecule is turned off in stromal cells, growth of cancer cells in the prostate slows. But when the molecule is turned off in the epithelial cells, it removes one of the body's natural inhibitors that prevents prostate cancer cells from spreading, making cells more likely to invade other tissues.

"While the androgen receptor is really driving prostate cancer, in another sense it appears that the receptor also normally inhibits the spread of cancer cells. It seems to have a dual role. Manipulating the androgen receptor can increase or decrease either of these actions depending on precisely how it's done," said Messing.

Chang says the molecule's versatility in the prostate should not come as a surprise, since the molecule's function elsewhere depends on its location.

"The effects of the androgen receptor on hair growth in men vary dramatically depending on where in the body the receptor is working," said Chang. "When the receptor is very active in the mustache area, more hair grows. When it's very active on the top of the skull, toward the front, hair falls out and men become bald. And the hair on the back of the head is insensitive to the receptor. The effects of hormones depend on the location.

"We found that the same is true within the cells of the prostate itself," said Chang, who is a faculty member in the departments of Urology and Pathology and the James P. Wilmot Cancer Center.

Chang says it's likely that the androgen receptor works differently in different cells partly because the assortment of molecular colleagues it works with within
'/>"/>

Contact: Leslie White
Leslie_White@urmc.rochester.edu
585-273-1119
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Risk of common vaginal infection linked to preterm birth appears higher for blacks
2. Features of replication suggest viruses have common themes, vulnerabilities
3. Genetics determine optimal drug dose of common anticoagulant
4. All eukaryotic kinases share 1 common set of substrates
5. 60 second test could help early diagnosis of common brain diseases
6. Soy isoflavone may inhibit common gastrointestinal illness in infants
7. The importance of gene regulation for common human disease
8. Genes and environment grant funds close look at nature-nurture overlap in common diseases
9. Thriving hybrid salamanders contradict common wisdom
10. UCI researchers restore memory process in most common form of mental disability
11. Drug commonly used to treat bipolar disorder dramatically increases lifespan in worms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/26/2015)... , August 26, 2015 ... Four, and Five Factor), Application (Travel & Immigration, Government, ... - Global Forecast to 2020", published by MarketsandMarkets, Multi-Factor ... by 2020, growing at a CAGR of 17.7% between ... and 82 F igures spread through 169 ...
(Date:8/20/2015)... , Aug. 20, 2015   Sensory, Inc ... improving the user experience and security of consumer ... today announced that its TrulySecure™ is ... software to be FIDO Certified™. The ... compliance with the FIDO UAF (Universal Authentication Framework) ...
(Date:8/17/2015)... , Aug. 17, 2015  NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market and ... sales campaign for Q4 2015. The new marketing campaign ... consisting of Amplitude Marketing Group ( http://amplitudemarketing.com/ ) and ... is a leader in retail driven marketing and brand ...
Breaking Biology News(10 mins):Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 2Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 3Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 4Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 5TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 2TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 4TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 5NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3
... compounds that could be promising candidates for drug development ... Eliza Hall Institute,s medicinal chemistry group. Dr Jonathan ... of ,filters, that can be used to weed out ... when screening a chemical library for compounds that could ...
... in dramatic decline, researchers would love to know more about ... can better protect the creatures, habitat. Now, a team ... for Sea Turtle Research teasing that information from the turtles, ... Vander Zanden writes in Tuesday,s online edition of the journal ...
... The Genetics Society of America (GSA) biennial meeting, ... 12-15, 2010, at the Sheraton Boston, Massachusetts, will ... such as flies, yeast, fungi, mice and other non-human ... the impact of basic research on the study of ...
Cached Biology News:Compound screening for drug development made simpler 2Increasingly threatened loggerheads follow their own paths in travel, eating 2Increasingly threatened loggerheads follow their own paths in travel, eating 3GENETICS 2010: Model Organisms to Human Biology Meeting 2GENETICS 2010: Model Organisms to Human Biology Meeting 3GENETICS 2010: Model Organisms to Human Biology Meeting 4
(Date:9/1/2015)... September 2, 2015 ... die Forschung und Entwicklung neuartiger Therapien für ... Darmerkrankungen und Reizdarm konzentriert, erhält vom US ... sein neues Medikament patentiert wird. Das Medikament ... bei Kindern verhindert und Entzündungen vorbeugt.   ...
(Date:9/1/2015)... 2015 Prostate cancer is the second ... men. One in seven men will be diagnosed ... are diagnosed annually. That said, not every diagnosis ... new technique, MRI Fusion Biopsy, to more accurately ... only the affected areas and monitoring areas ...
(Date:9/1/2015)... ... September 01, 2015 , ... VetStem Biopharma announces new ... facet joint problems can be caused by injuries and abnormalities of the cervical ... roots or of the spinal cord itself. This can manifest itself as any ...
(Date:9/1/2015)... , Sept. 1, 2015   Medfusion, ... facilitating the relationship between doctors and patients, today ... Durham, N.C. -based venture capital firms. ... and business association with Bull City Venture Partners ... , Medfusion Founder and Executive Chairman. "Both firms, ...
Breaking Biology Technology:Das Patent von Swecure zur Verhinderung von Allergien bei Kindern wird in den USA zugelassen 2September Is Prostate Cancer Awareness Month 2September Is Prostate Cancer Awareness Month 3September Is Prostate Cancer Awareness Month 4VetStem Biopharma Announces New Clinical Research Program for Equine Cervical Facet Joint Disease 2VetStem Biopharma Announces New Clinical Research Program for Equine Cervical Facet Joint Disease 3Medfusion Secures Funding to Continue Evolution and Advance Mobile Strategy 2Medfusion Secures Funding to Continue Evolution and Advance Mobile Strategy 3
... - The parent company of a Florida manufacturer of ... of the product following the signing of a bill ... to be implanted. , ,Scott Silverman, chairman and CEO ... the company's practices are consistent with what the law ...
... , and MSN have marketers reconsidering the ... months, popular search engines have undergone significant changes: Google ... results; MSN booted all Yahoo ads from its search ... the effects of these changes among competing search engines ...
... Racine, Wis. - Between being one of the top ... of sports fans that call themselves cheeseheads, Wisconsin is clearly ... thanks to a new agreement signed between two Racine organizations, ... lactose roster. , ,The Center for Advanced Technology ...
Cached Biology Technology:Company defends RFID implant product 2Location, location, location: Spots to consider for online ads 2Location, location, location: Spots to consider for online ads 3Location, location, location: Spots to consider for online ads 4CATI signs agreement for food processing technology 2
... and ES1301 mutS are mismatch repair minus ... strains prevents repair of the newly synthesized ... efficiencies and making them helpful in such ... II Mutagenesis Systems. Both ES1301 and BMH ...
propidium iodide *1.0 mg/mL solution in water*...
Applications: (+) Immunocytochemistry and immunohistochemistry...
MOUSE ANTI RAT KAPPA/LAMBDA:HRP Immunogen: MARK-1: Rat kappa light chains (IR202 and IR968)MARL-15: Rat lambda light chains (RH58, IR31)...
Biology Products: