Navigation Links
Why a common treatment for prostate cancer ultimately fails
Date:8/21/2008

Some of the drugs given to many men during their fight against prostate cancer can actually spur some cancer cells to grow, researchers have found. The findings were published online this week in a pair of papers in the Proceedings of the National Academy of Sciences.

The results may help explain a phenomenon that has bedeviled patients for decades. Hormone therapy, a common treatment for men with advanced prostate cancer, generally keeps the cancer at bay for a year or two. But then, for reasons scientists have never understood, the treatment fails in patients whose disease has spread the cancer begins to grow again, at a time when patients have few treatment options left.

The new findings by a team led by Chawnshang Chang, Ph.D., director of the George Whipple Laboratory for Cancer Research at the University of Rochester Medical Center, help explain the process by showing that the androgen receptor, through which male hormones like testosterone work, is much more versatile than previously thought. Under certain conditions the molecule spurs growth, and at other times the molecule squelches growth just like the same molecule does to hair in different locations on a man's head.

The new findings raise the possibility that under some conditions, some treatments designed to treat prostate cancer could instead remove one of the body's natural brakes on the spread of the disease in the body. The researchers stress that the results are based on laboratory studies and on findings in mice, and it's too soon to know yet whether the findings apply directly to prostate cancer in men.

Understanding the effects of the androgen receptor gives physicians a toehold in efforts to develop more effective treatments for men with prostate cancer. That would be welcome news for the one of every six men who will get the disease during his lifetime. More than 28,000 men die from the disease in the United States each year, according to the A
'/>"/>

Contact: Leslie White
Leslie_White@urmc.rochester.edu
585-273-1119
University of Rochester Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2 3 4

Related biology news :

1. Risk of common vaginal infection linked to preterm birth appears higher for blacks
2. Features of replication suggest viruses have common themes, vulnerabilities
3. Genetics determine optimal drug dose of common anticoagulant
4. All eukaryotic kinases share 1 common set of substrates
5. 60 second test could help early diagnosis of common brain diseases
6. Soy isoflavone may inhibit common gastrointestinal illness in infants
7. The importance of gene regulation for common human disease
8. Genes and environment grant funds close look at nature-nurture overlap in common diseases
9. Thriving hybrid salamanders contradict common wisdom
10. UCI researchers restore memory process in most common form of mental disability
11. Drug commonly used to treat bipolar disorder dramatically increases lifespan in worms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/4/2008)...rson,s body mass consisting of skeletal muscle, ch... those found in the limbs can result in significa...y of Illinois kinesiology and community health pro...ed that the antioxidant properties of Vitamin E ma... pro-inflammatory cytokines, in vitro, in various ...
(Date:12/4/2008)...l be published by Springer as of January 2009. The...ries Science, previously published by Wiley-Blackw...ion of basic and applied research articles in a br...cience. , Published in English six times a year... articles covering a wide array of topics in both ...
(Date:12/3/2008)...er 3, 2008. The first 5-year forest inventory repo...w available to the public: California,s Forest Res...Analysis Report., Here are some key findings from...the state,s 100 million acres;19 million acres is ...urban interface account for most of the housing gr...
(Date:12/3/2008)...University study suggests that evolution can behav...depend on an energy-efficient style of four-footed...cats seem to have evolved a profoundly inefficient...in slow motion. , "It is usually assumed that ef...l Schmitt, a Duke associate professor of evolution...
Breaking Biology News(10 mins):Vitamin E shows possible promise in easing chronic inflammation 2Vitamin E shows possible promise in easing chronic inflammation 3Forest inventories in California include more than trees 2Forest inventories in California include more than trees 3Dogs chase efficiently, but cats skulk counterintuitively 2Evotec Reports Third Quarter 2007 Results 1782 1Evotec Reports Third Quarter 2007 Results 1782 2Evotec Reports Third Quarter 2007 Results 1782 3Evotec Reports Third Quarter 2007 Results 1782 4Evotec Reports Third Quarter 2007 Results 1782 5Evotec Reports Third Quarter 2007 Results 1782 6Evotec Reports Third Quarter 2007 Results 1782 7Evotec Reports Third Quarter 2007 Results 1782 8PET scans useful for some cancer treatment but how do patients fare 3F 6153 1PET scans useful for some cancer treatment but how do patients fare 3F 6153 2Beckman Coulter to Present at the Credit Suisse Global Healthcare Conference 6150 1Beckman Coulter to Present at the Credit Suisse Global Healthcare Conference 6150 2NightHawk Radiology Holdings Inc to Speak at Annual Piper Jaffray Healthcare Conference on November 28 2007 6148 1NightHawk Radiology Holdings Inc to Speak at Annual Piper Jaffray Healthcare Conference on November 28 2007 6148 2
...vidence that an extinct woodpecker is alive and we...aken identity. Research published today in the ope...ages thought to be the Ivory-billed Woodpecker Cam...ecker species. , J. Martin Collinson compared Davi...of the supposed Ivory-billed Woodpecker with fresh...
... novel video-imaging system, researchers at the Un...een able to observe proteins important in Alzheime...tensions of nerve cells that carry proteins away f...xonal transport is important for studying many neu... Journal of Neuroscience. , Axonal transport oft...
...cess of long term hip replacement surgery may lie ... print in the Annals of the Rheumatic Diseases. , ... people, just over half of whom (162) had problems...urgery. , Among those with symptoms, 91 had ear...condition in which the artificial joint comes loos...
...children’s game "red light green light," winners a...quickly than their comrades. New research reveals ...pulse control being the big winner. , "The researc...s movements, which helps explain the impulsivity o...disorder," study co-author Jeffrey Schall, E. Bron...
Other Biology News:A case of mistaken identity for the ivory-billed woodpecker? 2Proteins important in Alzheimer's, Parkinson's disease travel in the slow lane 2Racing neurons control whether we stop or go 2Racing neurons control whether we stop or go 3
(Date:12/4/2008)...wswire-FirstCall/ -- Favrille, Inc.,(OTC Bulletin..."), a health,information company focused on secur... Records (PHRs), announced today that two signific...definitive merger agreement have been met. , ...80404/LAF521LOGO ) , "We are pleased to ann...
(Date:12/4/2008)...rate research of potential vaccine for low-resourc...Md., Dec. 4 The biotech company Le... organization PATH announced today a partnership t...ine. PATH will initially invest $3 million over 27...lopment of a H5N1 virus-like particle (VLP) protot...
(Date:12/4/2008)... 4 Raymond J. De Hont, C...poration (NYSE: MPR ), announced today that the C...ecember 3, 2008, declared a quarterly dividend of ...holders of record at the close of business on Febr...crease over the same period last year. , , ...
(Date:12/4/2008)... Quarter 2008 and Full Year 2009 Earnings Guidance...wire-FirstCall/ -- DuPont, (NYSE: DD ) today an...challenges and strengthen the company,s competitiv...zing cash flow, and provided earnings guidance for..., , A steep global decline in construction a...
Breaking Biology Technology:Favrille and MyMedicalRecords.com, Inc. Obtain Shareholder Approval to Move Forward With Merger 2Favrille and MyMedicalRecords.com, Inc. Obtain Shareholder Approval to Move Forward With Merger 3Favrille and MyMedicalRecords.com, Inc. Obtain Shareholder Approval to Move Forward With Merger 4Favrille and MyMedicalRecords.com, Inc. Obtain Shareholder Approval to Move Forward With Merger 5Lentigen Corporation and PATH Announce Partnership on Innovative Vaccine for Pandemic Influenza 2Lentigen Corporation and PATH Announce Partnership on Innovative Vaccine for Pandemic Influenza 3Met-Pro Corporation Declares Quarterly Dividend 2DuPont Takes Aggressive Actions to Strengthen Competitiveness and Increase Cash Flow 2DuPont Takes Aggressive Actions to Strengthen Competitiveness and Increase Cash Flow 3DuPont Takes Aggressive Actions to Strengthen Competitiveness and Increase Cash Flow 4DuPont Takes Aggressive Actions to Strengthen Competitiveness and Increase Cash Flow 5DuPont Takes Aggressive Actions to Strengthen Competitiveness and Increase Cash Flow 6
...ctivePro In Vitro Translation Kit , ... convenient method for synthesizing p...dvantages of these in vitro translation systems ov...ms are greater flexibility, faster , ...tocols. , , Ambions <A ,...
...NA-free Kit , , Orders o...l than with wild type DNase I , ... clean-up in just 20 minutes , ... DNase treatment is the method of choice fo...g genomic DNA from RNA samples in , ...
... With the emergence of more and , ...ession analysis (e.g. , array analysi...in , these studies has become increas... , Ambion is committed to defining what "high , ...the best RNA available from , any sou...
... RNA later Tissue Collection: RNA ,...hly Dissected Tissue and Cells. , ...requires rapid , processing or ... samples. Tissue samples must be quick... by immediate disruption in lysis buffer. , ...
Other Biology Technology:Translate High Yields of Biologically Active Proteins 2Translate High Yields of Biologically Active Proteins 3Translate High Yields of Biologically Active Proteins 4The Fastest, Simplest, and Most Effective Way to Remove DNA Contamination 2The Fastest, Simplest, and Most Effective Way to Remove DNA Contamination 3SUPERIOR RNA FOR DEMANDING APPLICATIONS 2SUPERIOR RNA FOR DEMANDING APPLICATIONS 3SUPERIOR RNA FOR DEMANDING APPLICATIONS 4SUPERIOR RNA FOR DEMANDING APPLICATIONS 5SUPERIOR RNA FOR DEMANDING APPLICATIONS 6SUPERIOR RNA FOR DEMANDING APPLICATIONS 7Stabilizing RNA in Fresh and Frozen Tissues for RNA Isolation 2Stabilizing RNA in Fresh and Frozen Tissues for RNA Isolation 3Stabilizing RNA in Fresh and Frozen Tissues for RNA Isolation 4
... flow cytometry system is the superior cell-sortin... 25 years, BD cell sorters have been the gold stan...utical, and biotechnology research facilities thro... today, we have improved the BD FACS VantageTM and...
SpliceArray Services is a microarray service provider that supports industrial and academic researchers. We are a Certified Servive Provider of Agilent, and we provide expression profiling services
Control and regulate cell stretching or compression of a single cell culture on a microscope stage. Computer controlled so you can precisely regulate the degree and frequency of the strain to produce
...logic production demands on cell and tissue cultur...opulations. Therefore, both cell concentration and...urately and precisely. The new Vi-CELLTM Cell Viab...ctive means to perform the trypan blue dye exclusi...
Biology Products: