Navigation Links
Whooping cough vaccine antigen disappearing from bacteria in US
Date:12/12/2013

Vaccines for whooping cough contain three to five protective antigens, the presence of which are critical to the vaccine's effectiveness. But one of the antigens, pertactin, which had been present in almost all isolates of Bordetella pertussis in the US as late as 2010, is now absent from more than half of them, according to a paper published ahead of print in Clinical and Vaccine Immunology.

"These findings tell us that there is an evolutionary advantage to lacking the protein that may have important vaccine implications," says first author Lucia C. Pawloski, of the Centers for Disease Control and Prevention, Atlanta, GA.

In the study, the researchers screened 1,300 isolates dating from 1935-2012, obtained from outbreak and surveillance studies. They used polymerase chain reaction (PCR) to identify DNA insertions into the pertactin gene, which prevents expression of that gene. The earliest such isolate was from 1994, and the next, 2010. There were 267 such isolates.

Thanks to the vaccine's other antigens, the vaccine remains effective, but that does not mean public health authorities should be complacent.

"This recent and drastic change in response to a particular vaccine antigen highlights the need to continue monitoring the circulating bacterial population to allow us to better predict future potential vaccine antigens and respond to the recent upsurge in pertussis," says Pawloski.

It is particularly important that pregnant women be vaccinated against pertussis, since infants are at greatest risk for having severe, potentially life-threatening complications from pertussis.

"After receiving this vaccine, a pregnant woman's body creates protective antibodies and passes some of them to her baby before birth," says Pawloski.

Those antibodies provide the baby with some protection that lasts until it is old enough to be vaccinated. However, fewer than 10 percent
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Pneumonia revealed in a cough
2. Queens scientists seek vaccine for Pseudomonas infection
3. In search for a vaccine, IU biologist receives $2.3 million to explore chlamydia genomics
4. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
5. SFU HIV/AIDS vaccine research gets financial boost
6. Researchers identify Achilles heel of dengue virus, target for future vaccines
7. AAPS National Biotechnology Conference to highlight innovative vaccines
8. Army study: DNA vaccine and duck eggs protect against hantavirus disease
9. Sensitive test helps improve vaccine safety
10. Overweight? Theres a vaccine for that
11. Vaccine and antibiotics stabilized so refrigeration is not needed -- NIH study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... GOTHENBURG, Sweden , April 2, 2015 ... for its touch fingerprint sensor FPC1025 from the distributor ... Deliveries will commence during Q2 2015 although the major ... 2015. The sensors will be used by smartphone manufacturers ... of 110 MSEK is included in the communicated revenue ...
(Date:4/1/2015)... 1, 2015   Medisafe ™, the leading global ... iOS and Android smartphones and ... into the platform to allow patients to track and ... first time, patients will be able to visualize in ... important biometrics, such as glucose levels and blood pressure. ...
(Date:3/31/2015)... March 31, 2015   Guidepoint , a leading ... the Post-Surgical Pain Management TRACKER, part of the ... trends in the medical device and therapeutics markets. The ... including treatment volumes, market share, and adoption rates across ... with joint surgery. The Post-Surgical Pain Management ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3
... 2007 (Aliso Viejo, California) Ossur, an emerging leader ... a period of integration, is pleased to announce that ... of a two year cervical collar study performed by ... Tissue Interface Pressure from Four Cervical Collars, finds ...
... National Science Foundation has awarded Joan Edwards, the Washington ... professor of physics at Pomona College, a grant in ... of a high-speed imaging facility at Williams College for ... applications in the sciences. The project builds on ...
... researchers, in collaboration with the International Maize and ... research illustrates the major genetic improvements possible without ... use wild relatives of wheat as sources of ... team leader Dr Phil Larkin says. Unfortunately ...
Cached Biology News:Mayo Clinic study: Ossur's collars superior in immobilization and reduction of pressure 2NSF awards Williams funding for high-speed imaging faciltity 2Building disease-beating wheat 2
(Date:4/21/2015)... Staying true to their mission of ... product that makes the world a better place, the ... Institute (GBSI) to redesign their website ( http://www.gbsi.org ) ... strategy-based. , "Biomedical research is not always an easy ... promote it in a narrative way on a website," ...
(Date:4/21/2015)... 2015 Invetech , a global ... and contract manufacturing, and  NanoCellect Biomedical, a ... cell sorting technology for life science researchers, today ... cytometry platform. Headquartered in ... a microchip-based cell sorting technology. NanoCellect,s flow cytometry ...
(Date:4/21/2015)...  Tute Genomics, a leading provider of cloud-based genomic medicine ... as VP of Marketing. Mr. Forsythe is the latest to ... its commercial operations over the last two quarters. ... is a tremendous addition to the Tute Genomics team," ... Genomics. "Josh,s vast experience commercializing software technology in a highly ...
(Date:4/21/2015)... and RESEARCH TRIANGLE PARK, N.C. ... Corporation (NASDAQ: UTHR ) announced today that it ... market open on Tuesday, April 28, 2015. ... April 28, 2015, at 9:00 a.m. Eastern Time.  The ... dialing 1-970-315-0533.  A rebroadcast of the teleconference will be ...
Breaking Biology Technology:Visceral Tells GBSI’s Story Within 30 Seconds of Attention 2Visceral Tells GBSI’s Story Within 30 Seconds of Attention 3NanoCellect And Invetech Announce Collaboration To Develop Novel Flow Cytometry Platform For Cell Sorting And Analysis 2NanoCellect And Invetech Announce Collaboration To Develop Novel Flow Cytometry Platform For Cell Sorting And Analysis 3Tute Genomics Continues Expansion of Genomic Medicine Commercial Operations; Appoints Josh Forsythe as New VP of Marketing 2Tute Genomics Continues Expansion of Genomic Medicine Commercial Operations; Appoints Josh Forsythe as New VP of Marketing 3Tute Genomics Continues Expansion of Genomic Medicine Commercial Operations; Appoints Josh Forsythe as New VP of Marketing 4
... Aug. 11 /PRNewswire-FirstCall/ - MIGENIX Inc. ("MIGENIX"),announced today ... Holdings,Inc. ("DJohnson"), a significant shareholder of MIGENIX, that ... of shareholders scheduled for,October 31, 2008. As part ... of,its board of directors from seven members to ...
... CLAREMONT, Calif., Aug. 11 /Xinhua-PRNewswire-FirstCall/ --,Kiwa Bio-Tech Products ... the second quarter of 2008 ended June 30 ... $1,872,647 for the second,quarter of 2007. Revenues for ... 60% from the previous year., The significant ...
... 4:30 p.m. Eastern Time -, SAN FRANCISCO, Aug. ... on its corporate progress and financial,results for the quarter ... findings of the Dimebon 12-month pivotal,trial in Alzheimer,s disease ... results from our Phase 2 study in Huntington,s disease,announced ...
Cached Biology Technology:Migenix averts proxy contest; reaches agreement with DJohnson holdings 2Migenix averts proxy contest; reaches agreement with DJohnson holdings 3Migenix averts proxy contest; reaches agreement with DJohnson holdings 4Kiwa Bio-Tech 2nd Quarter Revenues Increase 61.7% to $3 Million, Six Month Revenues Top $5.2 Million 2Kiwa Bio-Tech 2nd Quarter Revenues Increase 61.7% to $3 Million, Six Month Revenues Top $5.2 Million 3Kiwa Bio-Tech 2nd Quarter Revenues Increase 61.7% to $3 Million, Six Month Revenues Top $5.2 Million 4Kiwa Bio-Tech 2nd Quarter Revenues Increase 61.7% to $3 Million, Six Month Revenues Top $5.2 Million 5Kiwa Bio-Tech 2nd Quarter Revenues Increase 61.7% to $3 Million, Six Month Revenues Top $5.2 Million 6Kiwa Bio-Tech 2nd Quarter Revenues Increase 61.7% to $3 Million, Six Month Revenues Top $5.2 Million 7Kiwa Bio-Tech 2nd Quarter Revenues Increase 61.7% to $3 Million, Six Month Revenues Top $5.2 Million 8Kiwa Bio-Tech 2nd Quarter Revenues Increase 61.7% to $3 Million, Six Month Revenues Top $5.2 Million 9Medivation Reports Second Quarter 2008 Financial Results and Provides Corporate Update 2Medivation Reports Second Quarter 2008 Financial Results and Provides Corporate Update 3Medivation Reports Second Quarter 2008 Financial Results and Provides Corporate Update 4Medivation Reports Second Quarter 2008 Financial Results and Provides Corporate Update 5Medivation Reports Second Quarter 2008 Financial Results and Provides Corporate Update 6Medivation Reports Second Quarter 2008 Financial Results and Provides Corporate Update 7Medivation Reports Second Quarter 2008 Financial Results and Provides Corporate Update 8
Mouse monoclonal antibody to RNase L...
Mouse polyclonal antibody to MCFD2 - multiple coagulation factor deficiency 2...
Anti (porcine) Vitronectin...
... proud to work in collaboration with Pall ... syringe filters in a variety of membrane ... for use on the Caliper TPWII, MultiDose, ... Pricing for our Automation Certified Syringe Filters ...
Biology Products: