Navigation Links
Who will recover spontaneously from hepatitis C virus infection
Date:8/29/2007

More than 3% of world population is infected with hepatitis C virus (HCV). The outcome of HCV infections is either self recovery or chronic hepatitis, and many of the chronic infections will develop into liver cirrhosis or liver cancer. Since there is no cure for chronic hepatitis C, nor is there any approved vaccine for this virus, hepatitis C is currently a major health problem worldwide.

Twenty to fifty percent of HCV infected patients recovers spontaneously. The hepatitis C patients and their relatives like to know if his/her infection would fall into the category for self recovery.

A research article to be published on August 21 in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Mihm from Georg-August-Universitt spent more than 8 years working with a cohort of 67 patients who spontaneously recovered from HCV infection. In addition to these, the researchers included a similar number of patients with chronic HCV infection. Large sample size allowed these investigators to obtain results with great statistical significance, and to draw very reliable conclusions.

One conclusion reported by the investigators is, patients who self recovered usually have lower levels of HCV antibody. Thus patients with lower HCV antibody titer may have a brighter clinical outcome. However, for a practical standard to be established to define a low HCV antibody titer, more effort is needed by investigators in the future.

Another interesting conclusion reached by these investigators is, co-infection by hepatitis B virus (HBV) is associated with a higher possibility of self recovery. The investigators suggested that the infection of HBV interferes with the HCV replication, which would finally lead to virus eradiacation.. HCV patients co-infected by hepatitis A virus also have a better chance of self recovery, possibly by a similar mechanism.

Active iv drug users are less likely to self recover, for a couple of reasons: 1, they have a higher incidence of re-infection; 2, drugs have been shown to inhibit the expression of antiviral cytokines such as IFN- and IFN-; 3, HCV replication has been shown to be enhanced both by morphine use and morphine withdrawal.

Several different genotypes of HCV were discovered. The HCV genotype studied by Dr. Milms group is type 1b, which is the prevalent genotype in Germany, and in China.


'/>"/>
Contact: Lixin Zhu
wjg@wjgnet.com
0086-108-538-1892
World Journal of Gastroenterology
Source:Eurekalert

Related biology news :

1. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
2. Dinosaur DNA? New Patent Covers Degraded DNA recovery
3. Bone Density Recovers After Teens Stop Injected Contraceptive
4. U-M team recovers ancient whale in Egyptian desert
5. Low oxygen likely made Great Dying worse, greatly delayed recovery
6. Tsunami-damaged coral reefs should be left to recover naturally, say scientists
7. Combination therapy leads to partial recovery from spinal cord injury in rats
8. Study shows eutrophic lakes may not recover for a millennium
9. Time and money make a difference in endangered species recovery
10. Adult stem cells aid recovery in animal model of cerebral palsy
11. Infused spleen cells found not to impact islet recovery and reversal of type 1 diabetes in mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2016)... PROVO and SANDY, ... Screening Ontario (NSO), which operates the highest sample volume ... testing, and Tute Genomics and UNIConnect, leaders in clinical ... today announced the launch of a project to establish ... testing panel. NSO has been contracted ...
(Date:3/18/2016)... 2016 --> --> ... Manned & Unmanned Vehicles, Physical infrastructure and Perimeter Surveillance & ... the border security market and the continuing migration crisis in ... Europe has led visiongain to publish this unique ... --> defence & security companies in the border ...
(Date:3/15/2016)... ALBANY, New York , March 15, 2016 ... a new market report published by Transparency Market Research "Digital ... Growth, Trends and Forecast 2015 - 2023," the global digital ... at US$ 731.9 Mn in 2014 and is forecast to ... to 2023. Growth of micro, small and medium enterprises (MSMEs) ...
Breaking Biology News(10 mins):
(Date:5/23/2016)... ... May 23, 2016 , ... ... solutions and services based in Aurora, Ohio, has broken ground on a new ... the Research Triangle Park area, this new location solidifies a commitment to business ...
(Date:5/20/2016)... ... ... The leading Regenerative Veterinary Medicine Company, VetStem Biopharma ., is proud ... of their own patients with the VetStem Cell Therapy. Each of these veterinarians has ... patients. , The veterinarians are Dr Ross Rich former owner of Cave Creek ...
(Date:5/20/2016)... MD (PRWEB) , ... May 20, 2016 , ... The ... with Listeria, as reported by Food Safety News on May 12, 2016(1), demonstrates the ... to Ted Olsen, CEO of Baltimore-based biotech firm, PathSensors, Inc. , ...
(Date:5/19/2016)... May 19, 2016 There is ... recover given the relentless pressures in pricing and lack ... the investors circle though - numerous opportunities are up ... today,s session, ActiveWallSt.com,s presents four names in this sector: ... Pharmaceuticals Inc. (NASDAQ: VTAE ), Anthera Pharmaceuticals ...
Breaking Biology Technology: