Navigation Links
Who reprograms rat astrocytes into neurons?

To date, it remains poorly understood whether astrocytes can be easily reprogrammed into neurons. Mash1 and Brn2 have been previously shown to cooperate to reprogram fibroblasts into neurons. Dr. Yongjun Wang and team from Shanghai University of Traditional Chinese Medicine in China found that and found that Brn2 was expressed in astrocytes from 2-month-old Sprague-Dawley rats, but Mash1 was not detectable. Thus, the researchers hypothesized that Mash1 alone could be used to reprogram astrocytes into neurons. Murine stem cell virus (MSCV)-Mash1 recombinant plasmid was constructed and transfected into GP2-293t cells to produce retrovirus. One week later, the changes in morphology of astrocytes were detectable, which showed typical neuronal characteristics. Moreover, β-tubulin expression levels were significantly higher in astrocytes expressing Mash1 than in control cells. These results, published in the Neural Regeneration Research (Vol. 9, No. 1, 2014), indicate that Mash1 alone can reprogram astrocytes into neurons. This method determined an easier process of reprogramming through the endogenous expression of important transcription factors, which avoids malignant transformation due to the spontaneous reactivation of viral transgenes.


Contact: Meng Zhao
Neural Regeneration Research

Page: 1

Related biology news :

1. Gene therapy reprograms scar tissue in damaged hearts into healthy heart muscle
2. Astrocytes control the generation of new neurons from neural stem cells
Post Your Comments:
Related Image:
Who reprograms rat astrocytes into neurons?
(Date:10/29/2015)... 29, 2015 Daon, a global leader in ... released a new version of its IdentityX Platform ... North America have already installed IdentityX v4.0 ... a FIDO UAF certified server component as ... activate FIDO features. These customers include some of the ...
(Date:10/29/2015)... YORK , Oct. 29, 2015 ... technology, announced a partnership with 2XU, a global ... to deliver a smart hat with advanced bio-sensing ... and other athletes to monitor key biometrics to ... the strategic partnership, the two companies will bring together ...
(Date:10/26/2015)... October 26, 2015 ... adds Biometrics Market Shares, ... as well as Emerging Biometrics Technologies: ... to its collection of IT and ... . --> ...
Breaking Biology News(10 mins):
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... ... Program that includes over 2,000 technical presentations offered in symposia, oral sessions, ... and applied spectroscopy, covers a wide range of applications such as, but not ...
(Date:11/26/2015)... 26, 2015 --> ... in imaging technologies, announced today that it has received a ... the Horizon 2020 European Union Framework Programme for Research and ... trial in breast cancer. , --> ... --> --> The study aims to ...
(Date:11/25/2015)... 25, 2015 2 nouvelles études permettent ... les différences entre les souches bactériennes retrouvées dans la ... des êtres humains . Ces recherches  ouvrent une nouvelle ... prise en charge efficace de l,un des problèmes ... chats .    --> 2 nouvelles études ...
(Date:11/25/2015)... , Nov. 25, 2015  Neurocrine Biosciences, Inc. (Nasdaq: ... , President and CEO of Neurocrine Biosciences, will be ... in New York . ... the website approximately 5 minutes prior to the presentation ... of the presentation will be available on the website ...
Breaking Biology Technology: