Navigation Links
Who reprograms rat astrocytes into neurons?
Date:3/21/2014

To date, it remains poorly understood whether astrocytes can be easily reprogrammed into neurons. Mash1 and Brn2 have been previously shown to cooperate to reprogram fibroblasts into neurons. Dr. Yongjun Wang and team from Shanghai University of Traditional Chinese Medicine in China found that and found that Brn2 was expressed in astrocytes from 2-month-old Sprague-Dawley rats, but Mash1 was not detectable. Thus, the researchers hypothesized that Mash1 alone could be used to reprogram astrocytes into neurons. Murine stem cell virus (MSCV)-Mash1 recombinant plasmid was constructed and transfected into GP2-293t cells to produce retrovirus. One week later, the changes in morphology of astrocytes were detectable, which showed typical neuronal characteristics. Moreover, β-tubulin expression levels were significantly higher in astrocytes expressing Mash1 than in control cells. These results, published in the Neural Regeneration Research (Vol. 9, No. 1, 2014), indicate that Mash1 alone can reprogram astrocytes into neurons. This method determined an easier process of reprogramming through the endogenous expression of important transcription factors, which avoids malignant transformation due to the spontaneous reactivation of viral transgenes.


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert  

Page: 1

Related biology news :

1. Gene therapy reprograms scar tissue in damaged hearts into healthy heart muscle
2. Astrocytes control the generation of new neurons from neural stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Who reprograms rat astrocytes into neurons?
(Date:5/12/2016)... , May 12, 2016 WearablesResearch.com , ... published the overview results from the Q1 wave of ... recent wave was consumers, receptivity to a program where ... with a health insurance company. "We were ... share," says Michael LaColla , CEO of Troubadour ...
(Date:5/3/2016)... May 3, 2016  Neurotechnology, a provider of ... MegaMatcher Automated Biometric Identification System (ABIS) , a ... projects. MegaMatcher ABIS can process multiple complex biometric ... combination of fingerprint, face or iris biometrics. It ... and MegaMatcher Accelerator , which have ...
(Date:4/28/2016)... 2016 First quarter 2016:   ... with the first quarter of 2015 The gross margin ... (loss: 18.8) and the operating margin was 40% (-13) ... Cash flow from operations was SEK 249.9 M (21.2) , ... unchanged, SEK 7,000-8,500 M. The operating margin for 2016 ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , June 27, 2016   Ginkgo Bioworks ... to industrial engineering, was today awarded as one ... selection of the world,s most innovative companies. Ginkgo ... scale for the real world in the nutrition, ... engineers work directly with customers including Fortune 500 ...
(Date:6/24/2016)... June 24, 2016 Epic Sciences unveiled ... cancers susceptible to PARP inhibitors by targeting homologous ... (CTCs). The new test has already been incorporated ... multiple cancer types. Over 230 clinical ... response pathways, including PARP, ATM, ATR, DNA-PK and ...
(Date:6/24/2016)... ... 24, 2016 , ... Researchers at the Universita Politecnica delle Marche in Ancona ... or pleural mesothelioma. Their findings are the subject of a new article on the ... are signposts in the blood, lung fluid or tissue of mesothelioma patients that can ...
(Date:6/23/2016)... ... 2016 , ... UAS LifeSciences, one of the leading manufacturers ... Probiotics, into Target stores nationwide. The company, which has been manufacturing high quality ... list of well-respected retailers. This list includes such fine stores as Whole Foods, ...
Breaking Biology Technology: