Navigation Links
Who reprograms rat astrocytes into neurons?
Date:3/21/2014

To date, it remains poorly understood whether astrocytes can be easily reprogrammed into neurons. Mash1 and Brn2 have been previously shown to cooperate to reprogram fibroblasts into neurons. Dr. Yongjun Wang and team from Shanghai University of Traditional Chinese Medicine in China found that and found that Brn2 was expressed in astrocytes from 2-month-old Sprague-Dawley rats, but Mash1 was not detectable. Thus, the researchers hypothesized that Mash1 alone could be used to reprogram astrocytes into neurons. Murine stem cell virus (MSCV)-Mash1 recombinant plasmid was constructed and transfected into GP2-293t cells to produce retrovirus. One week later, the changes in morphology of astrocytes were detectable, which showed typical neuronal characteristics. Moreover, β-tubulin expression levels were significantly higher in astrocytes expressing Mash1 than in control cells. These results, published in the Neural Regeneration Research (Vol. 9, No. 1, 2014), indicate that Mash1 alone can reprogram astrocytes into neurons. This method determined an easier process of reprogramming through the endogenous expression of important transcription factors, which avoids malignant transformation due to the spontaneous reactivation of viral transgenes.


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert  

Page: 1

Related biology news :

1. Gene therapy reprograms scar tissue in damaged hearts into healthy heart muscle
2. Astrocytes control the generation of new neurons from neural stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Who reprograms rat astrocytes into neurons?
(Date:8/14/2019)... ... 14, 2019 , ... Gateway Genomics , a leading developer of direct-to-consumer ... 38th annual Inc. 500|5000 list of fastest growing private companies, in the ... been founded and generating revenue by March 31, 2015. Ranking in the list is ...
(Date:8/6/2019)... DURHAM, N.C. (PRWEB) , ... August 06, 2019 ... ... Medicine (SCTM) identifies a computational modeling system that could have far-reaching implications for ... called partial least squares regression (PLSR), is able to predict which stem cell ...
(Date:8/6/2019)... RIVER FALLS, Wis. (PRWEB) , ... August 06, ... ... due to health, sustainability, and environmental concerns. One plant-based food in particular quickly ... to their animal-meat counterparts, product developers use a thermogelling and emulsifying ingredient such ...
Breaking Biology News(10 mins):
(Date:7/26/2019)... , ... July 25, 2019 , ... ... leaders through off-the-record collaboration and dialogue, today announces its Boston BD ... Hotel. As part of Biotech Week Boston , the event provides an ...
(Date:7/19/2019)... ... July 18, 2019 , ... World renowned two-time ... joining forces with California-based charity Coalition Duchenne for its 9th Annual Expedition Mt. ... awareness and funding for Duchenne muscular dystrophy and was founded by Sabahan Catherine ...
(Date:7/17/2019)... ... July 16, 2019 , ... Quidel ... report from Kalorama Information. Abbott, Roche and Siemens Healthineers and Response Biomedical also ... report, Worldwide Market for Point-of-Care (POC) Diagnostics . , Quidel is a ...
(Date:7/9/2019)... ... July 08, 2019 , ... Balluff has been named ... as the 2019 Innovative Product of the Year which highlights cutting-edge advancements and ... Sensors Expo & Conference 2019, held this week in San Jose, ...
Breaking Biology Technology: