Navigation Links
While focusing on heart disease, researchers discover new tactic against fatal muscular dystrophy
Date:2/8/2009

NEW YORK (Feb. 8, 2009) Based on a striking similarity between heart disease and Duchenne muscular dystrophy, researchers at Columbia University Medical Center have discovered that a new class of experimental drugs for heart failure may also help treat the fatal muscular disorder.

At first glance, heart failure and the muscle-wasting Duchenne disease couldn't appear more dissimilar. Duchenne affects boys usually before the age of 6, destroying their muscle cells. The boys become progressively weaker through their teens and usually die in their twenties. In people without Duchenne, heart failure typically starts much later in life, robbing the heart's pumping ability in the 7th, 8th or 9th decade of life.

But the new study found that the muscle cells affected in both diseases have sprung the same microscopic leak that ultimately weakens skeletal muscle in Duchenne and cardiac muscle in heart failure. The leak lets calcium slowly seep into the skeletal muscle cells, which are damaged from the excess calcium in Duchenne. In people with chronic heart failure, a similar calcium leak continuously weakens the force produced by the heart and also turns on a protein-digesting enzyme that damages its muscle fibers.

Andrew Marks, M.D., the study's leader, hypothesized that a new class of experimental drugs developed at CUMC which he had designed to plug the leak in the heart could also work for Duchenne.

The drugs, when given to mice with Duchenne, dramatically improved muscle strength and reduced the number of damaged muscle cells.

"This was extremely exciting to us," says Dr. Marks, chair of the Department of Physiology & Cellular Biophysics and Clyde and Helen Wu Professor of Molecular Cardiology. "If it works in people, our drug won't be a cure, but it could slow the pace of muscle degeneration and extend the lives of people with Duchenne."

The study was published online Feb. 8 in Nature Medicine. Though
'/>"/>

Contact: Alex Lyda
mal2133@columbia.edu
212-305-0820
Columbia University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. U-M ballast-free ship could cut costs while blocking aquatic invaders
2. Fueling ethanol production while protecting water quality
3. Johns Hopkins researchers detect sweet cacophony while listening to cellular cross-talk
4. ESA satellites focusing on the Arctic
5. Abnormal fat metabolism underlies heart problems in diabetic patients
6. High blood pressure, low energy -- a recipe for heart failure
7. Human derived stem cells can repair rat hearts damaged by heart attack
8. Geron Demonstrates hESC-derived cardiomyocytes improve heart function after myocardial infarction
9. Heart of Herschel to be presented to media
10. Minimally invasive heart surgery research wins NIH award
11. A step toward tissue-engineered heart structures for children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... puzzle behind nature,s ability to split the water ... development of artificial photosynthesis for clean, green and ... collaboration of scientists led by researchers with the ... SLAC National Accelerator Laboratory. , Working at ... most powerful x-ray laser, the researchers were able ...
(Date:7/9/2014)... Guelph scientist that involved fitting bumblebees with tiny ... neonicotinoid pesticide hampers bees, ability to forage for ... professor in Guelph,s School of Environmental Sciences, and ... July 9 in the British Ecological Society,s journal ... how long-term pesticide exposure affects individual bees, day-to-day ...
(Date:7/9/2014)... With grilling season upon us, many backyard cooks are ... fatty hot dogs. But low fat can sometimes mean ... addressing the texture problem in low-fat wieners that are ... study was published in ACS, Journal of Agricultural ... colleagues note that hot-dog consumers have come to expect ...
Breaking Biology News(10 mins):Postcards from the photosynthetic edge 2Postcards from the photosynthetic edge 3Bee foraging chronically impaired by pesticide exposure: Study 2
... ARBOR, Mich. Researchers at the University of ... techniques for head and neck cancer to avoid ... A new study shows these principles and techniques ... swallowing complications. The researchers applied highly conformal, ...
... a CD, reminded her son, Ryan, of his 4-H project when ... three beautiful squealing black and white piglets at the auction," she ... Lincoln Town Car, because we didn,t have a truck." Recordings ... him four times a day. They were part of a new ...
... The European Nucleotide Archive (ENA) is launched today, consolidating ... point to globally comprehensive DNA and RNA sequence information. ... Institute (EMBL-EBI), a part of European Molecular Biology Laboratory. ... previously unimaginable amounts of data being deposited in the ...
Cached Biology News:U-M study achieves reduced side effects in head and neck cancer treatment 2Can a mother's voice spur recovery from a coma? 2Can a mother's voice spur recovery from a coma? 3Can a mother's voice spur recovery from a coma? 4Can a mother's voice spur recovery from a coma? 5Enabling easy access to DNA sequence information 2
(Date:1/15/2014)... AudioNotch is the internet's leading provider of Notched Sound ... Patients listen to sound therapy that is tailor-made for ... to months, their tinnitus volume decreases. , AudioNotch has previously ... Notched White Noise. Now, AudioNotch is pleased to announce to ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 Date: ... p.m. , Location: Warrington Country Club, 1360 Almshouse Road, Warrington, ... only national nonprofit organization solely dedicated to finding a cure ... those affected worldwide, will host its annual Crystal Ball on ...
(Date:1/14/2014)... Histogen, Inc., a regenerative medicine company developing ... simulated embryonic conditions, today announced that they have entered ... for physician-dispensed aesthetic products containing Histogen’s proprietary multipotent cell ... an amendment to the existing license between Histogen and ...
(Date:1/14/2014)... Calif. , Jan. 14, 2014 As pet owners drew ... doubt many of them wrote: "Take better care of my furry ... even designer clothes and top-brand carrying cases to take the little ... parents might also feel compelled to buy some pricey toys at ...
Breaking Biology Technology:Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2
... the only one completely confused by the Cingular merger with ... facts of the deal. Cingular Wireless acquires the assets and ... have 46 million customers, topping now No. 2 carrier Verizon ... keeps the rights to the AT&T Wireless brand and plans ...
... of the statewide Wisconsin business-plan contest this year ... survive the first round than they did during the inaugural ... initial abstracts of business ideas has passed, a panel of ... The survivors, who must write extended summaries for a further ...
... of Wisconsin-Milwaukee The director of the university's ... would leave for the University of Cincinnati in April. Professor ... feel valued, and that UW-Milwaukee does not have good ... , Menasha, Wis. Banta Corporation said it would ...
Cached Biology Technology:Cingular confusion 2Cingular confusion 3Coaching available for business-plan contest survivors 2
...
... Immunogen: Partially purified ... MA1-710 detects vitamin D receptor (VDR) ... amphibian, and fish tissues. This ... or glucocorticoid receptors. MA1-710 detects ...
... AccuPrime™ Pfx DNA Polymerase is ideal ... for downstream applications such as cloning ... provided by a proprietary enzyme preparation ... sp. with proofreading (3'Cut Site5' exonuclease) ...
... BV-10 offers precision beveling of ... 50m. The unique abrasive plate ... for greater control of the ... accomplished very rapidly and produces ...
Biology Products: