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Where optics meets medicine
Date:10/9/2008

of the light sensitive tissues in the retina at the back of the eye. With it, they can detect changes in blood vessels while the patient remains shot-free and relatively comfortable. "Our work enables us to measure the smallest capillaries using near infrared light, without injection of contrast agents," explains Stephen Burns, who is leading the research effort at Indiana, "and thus it holds significant promise for safely investigating retinal vascular changes in disease."

The traditional means of visualizing the retina is known as fluorescein angiography. It involves a shot in the arm of fluorescein dye that travels within seconds through the blood to the eye where it highlights flow and vessel integrity in the small capillaries in the retina. A series of photographs is taken to document the capillary network and reveal defects or changes. If vessels are damaged or abnormal, dye leaks out. Many shot-adverse patients find the procedure repellent enough that they put off getting these crucial eye exams.

To develop a patient-friendly alternative, Burns and his colleagues turned to adaptive optics that uses a confocal scanning laser opthalmoscope to produce retinal images in real time. A mirroring system helps guide the imaging beam to build a montage of the area being investigated. "In general, we could generate maps within a single imaging region without operator intervention once frames were chosen for alignment," Burns says.

Presentation FWW6, "Constructing Human Retinal Capillary Maps from Adaptive Optics SLO Imaging," Wednesday, Oct. 22, 5:15 p.m., Highland E, Rochester Riverside Convention Center

THE OPTICS OF ALZHEIMER'S DISEASE

One of the hallmarks of Alzheimer's disease is the formation of plaques made of protein aggregates in the brain tissue. There is still considerable debate among scientists as to whether these plaques are the cause of the neuronal death that occurs in Alzheimer's or just a by-produc
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Contact: Colleen Morrison
cmorri@osa.org
202-416-1437
Optical Society of America
Source:Eurekalert

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