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Where do you start when developing a new medicine?
Date:3/26/2014

ch of the three founding organisations and a multi-million pound contribution by GSK to fund an initial wave of projects.

Comments by the founding organisations:

Professor Patrick Vallance, President of Pharmaceuticals R&D at GSK, says: "Target validation is one of the greatest challenges in drug discovery. We need to understand better the mechanisms in our body related to disease to improve how we can develop the most effective medicines. By changing our business model, taking a more open-minded approach to sharing information and forging collaborations like the Centre for Therapeutic Target Validation, we believe there is an opportunity to accelerate the development of innovative new medicines. The UK leads the fields of genome sequencing and bioinformatics and I am delighted that GSK has the opportunity to collaborate here with two of its premier research institutions."

Professor Sir Mike Stratton, Director of the Wellcome Trust Sanger Institute, says: "Advances in genomics have led to a rapid increase in the availability of drug targets, providing enormous opportunity but also posing the problem of how we best convert this new knowledge into medicines. The challenge we now address is to identify those new targets with the greatest relevance to human disease which, in turn, will undoubtedly increase the speed and efficiency in which new medicines can be developed."

Professor Dame Janet Thornton, Director of the European Bioinformatics Institute, says: "Maximising our use of 'big data' in the life sciences is critical for solving some of society's most pressing problems. This collaboration gives us an opportunity to translate this complex information into biomedical discoveries. As biology becomes increasingly data-driven, pre-competitive collaborations such as the Centre for Therapeutic Target Validation have become crucial for improving efficiencies, driving down costs and providing the best opportunities to
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Source:Eurekalert  

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