Navigation Links
Where did you get those eyes and that brain?
Date:11/15/2010

Philadelphia, PA, 15 November 2010 - A family history of Alzheimer's disease significantly increases the risk for developing this disorder, but a new study in Biological Psychiatry suggests that which of your parents has the disease is very important.

Alzheimer's is the most common form of dementia in late-life, affecting over 5 million elderly in the United States alone. In order to develop preventative treatments, it is necessary to identify those individuals who are at highest risk for developing Alzheimer's.

Although individuals with a parental history of Alzheimer's are at increased risk for developing the disease, the specific biological and genetic mechanisms accounting for this increased risk are not known.

An important consideration may be a phenomenon called genomic imprinting, where the pattern of the inherited disease differs based on whether the risk genes are inherited from the mother or the father. Imprinting is a type of epigenetic regulation, meaning that long lasting changes in gene function are produced through regulatory mechanisms rather than by altering the sequence of the DNA.

In this new study, researchers set out to evaluate Alzheimer's risk in healthy, cognitively normal individuals by measuring their cerebrospinal fluid proteins, which are known to be altered in Alzheimer's. They compared individuals with a maternal or paternal history of Alzheimer's to individuals with no family history.

Only individuals whose mothers had Alzheimer's showed altered levels of a protein called amyloid, a major hallmark of Alzheimer's pathology, as well as proteins involved with oxidative stress (i.e., free radicals, which are harmful to the brain as well as the rest of the body). In contrast, individuals whose fathers had Alzheimer's and those with no family history had protein levels within normal range.

"Our data indicate that adult children of mothers with Alzheimer's may be at increased risk for developing the disease," explained Dr. Lisa Mosconi, the first author on the study. "It is therefore extremely important to understand the genetic mechanisms involved in maternal transmission of Alzheimer's disease, which are currently unknown. Identifying a genetic predictor for the disease might lead to preventive treatments years before the onset of clinical symptoms."

Dr. John Krystal, Editor of Biological Psychiatry, added: "This study is very important because we are just beginning to understand the epigenetic control of particular genes. In theory, some day, one might develop a medication that reduces the risks associated with a maternal history of Alzheimer's disease."

The authors cautioned that additional follow-up research is now needed to test the usefulness of these protein measures for predictive purposes and to investigate potential susceptibility genes for Alzheimer's disease.


'/>"/>

Contact: Chris J. Pfister
C.Pfister@elsevier.com
215-239-3266
Elsevier
Source:Eurekalert

Related biology news :

1. A new journal where molecular biology meets clinical research
2. Where optics meets medicine
3. Survey highlights support for nanotech in health fields but disapproval elsewhere
4. Where theres wildfire smoke, theres toxicity
5. Where do the fattest Germans live?
6. Mama whales teach babies where to eat
7. When fish farms are built along the coast, where does the waste go?
8. Healthy food availability could depend on where you live -- so does the quality of your diet
9. UTSA plant biologists publish where their peers are -- on the Web
10. Retail Anywhere Adds U.are.U Biometrics From DigitalPersona to Flagship Point of Sale Solution
11. Where do puffins go in the winter?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... , June 2, 2016 ... Manned Platforms, Unmanned Systems, Physical Infrastructure, Support & Other ... provider visiongain offers comprehensive analysis of the ... this market will generate revenues of $17.98 billion in ... acquired DVTEL Inc, a leader in software and hardware ...
(Date:5/20/2016)... , May 20, 2016  VoiceIt is ... partnership with VoicePass. By working together, ... experience.  Because VoiceIt and VoicePass take slightly different ... engines increases both security and usability. ... excitement about this new partnership. "This ...
(Date:5/9/2016)... -- Elevay is currently known as the ... high net worth professionals seeking travel for work   ... there is still no substitute for a face-to-face meeting. ... deal with a firm handshake. This is why wealthy ... citizenship via investment programs like those offered by the ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , ... June 23, 2016 , ... ... release of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering ... retention in this eBook by providing practical tips, tools, and strategies for clinical ...
(Date:6/23/2016)... /PRNewswire/ - FACIT has announced the creation of ... company, Propellon Therapeutics Inc. ("Propellon" or "the Company"), ... portfolio of first-in-class WDR5 inhibitors for the treatment ... represent an exciting class of therapies, possessing the ... cancer patients. Substantial advances have been achieved with ...
(Date:6/23/2016)... Lawrence, MA (PRWEB) , ... June 23, 2016 ... ... the Peel Plate® YM (Yeast and Mold) microbial test has received AOAC Research ... test platform of microbial tests introduced last year,” stated Bob Salter, Vice President ...
(Date:6/23/2016)... , June 23, 2016   EpiBiome , ... secured $1 million in debt financing from Silicon Valley ... up automation and to advance its drug development efforts, ... new facility. "SVB has been an incredible ... the services a traditional bank would provide," said Dr. ...
Breaking Biology Technology: