Navigation Links
When well-known flu strains 'hook up' dangerous progeny can result
Date:7/13/2011

e that may advance modern medicine's longstanding effort to learn how to predict when pandemic flu viruses will arise. An effort that in recent years has focused on study of H5, H7, and H9 subtypes of flu viruses because these all occasionally infect humans and, in the case of H5 viruses, can cause significant disease and death.

For their PNAS study, the researchers created four reassortant viruses with one or two genes from the H9N2 virus and the rest of the genes from pH1N1. They used two different H9N2 viruses to provide the genes. One was a typical H9N2 isolated from a bird in Asia. The other was an avian isolate that had been adapted to infect and transmit in mammals.

Perez and colleagues looked at the growth characteristics of these four viruses and also their infectivity and transmissibility in ferrets. Ferrets are used as a model for human infections as they are susceptible to the same viruses and show similar signs of infection. All four viruses were able to grow to relatively high levels in cell culture. Similarly all four viruses infected ferrets and showed similar signs of disease and levels of replication. Additionally, they were all able to transmit to ferrets housed in the same cage and allowed physical contact. Finally, three of the four viruses were able to transmit to ferrets that were physically separated but shared the same air.

The new results are important for several reasons according to Perez. "Ours is the first study to show respiratory transmission of an H9 reassortant virus in mammals without prior adaptation. This is important because a new virus must be able to transmit via the respiratory route to impact the human population significantly. Secondly, adapting some of the genes to mammalian hosts allows for more efficient infection and transmission. Finally, these studies indicate that the pH1N1 and H9N2 influenza subtypes are highly compatible for reassortment with each other. And this compatibility mean
'/>"/>

Contact: Lee Tune
ltune@umd.edu
301-405-4679
University of Maryland
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Nanosilver: A new name -- well-known effects
2. Researchers recreate SARS virus, open door for potential defenses against future strains
3. Novel bacterial strains clear algal toxins from drinking water
4. Genomes of 2 popular research strains of E. coli sequenced
5. Unexpectedly high rate of multiple strains in fungal infection
6. Scripps research scientists determine structure of immune molecule that counteracts HIV strains
7. H1N1 pandemic points to vaccine strategy for multiple flu strains
8. Same fungus, different strains
9. Study finds copper proves effective against new E. coli strains
10. Sleeping Beauty hooks up with herpes to fight brain disease
11. Pitt pharmacologists go on a molecular fishing trip and hook prize catch
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
When well-known flu strains 'hook up' dangerous progeny can result
(Date:12/11/2014)... Dec. 10, 2014  Data Sciences International (DSI), ... released a new series of digital telemetry implants ... researchers. M series, part of the PhysioTel™ Digital ... best possible physiologic data when incorporating functional endpoints ... endpoints to toxicology studies has evolved from short ...
(Date:12/10/2014)... Dec. 9, 2014  Valencell, a leader in performance ... a staggering demand from its licensees for highly accurate, ... is not solely coming from fitness and health sectors, ... "A wearable is only as useful as the ... the ultimate driver in long-term mass consumer adoption of ...
(Date:12/10/2014)... , Dec. 9, 2014 CIE San ... catalyst that provides the connective tissue that enhances care ... them to easily share client-level information; earned a second ... expand to organizations serving seniors aging in community and; ... partner on December 11 th 4-6p. ...
Breaking Biology News(10 mins):New telemetry implants expected to change how large animal toxicology studies are conducted 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4
... the October 2011 issue of Experimental Biology and ... Medical Center led by Stephen Tsang, MD, Ph.D have ... model for retinitis pigmentosa (RP) using novel bipartite gene ... by progressive degeneration of rod photoreceptors (which mediate night ...
... The carbon dioxide we exhale and the odors our skins ... hunt for human hosts to bite and spread diseases such ... at the University of California, Riverside have now performed experiments ... that transmit yellow fever and dengue -- respond to plumes ...
... Irvine, Calif., Sept. 30, 2011 A glucosamine-like dietary ... sclerosis, according to a UC Irvine study. UCI,s ... oral N-acetylglucosamine (GlcNAc), which is similar to but more ... and function of abnormal T-cells that in MS incorrectly ...
Cached Biology News:Cell-specific mechanism-based gene therapy approach to treat retinitis pigmentosa 2Cell-specific mechanism-based gene therapy approach to treat retinitis pigmentosa 3Flight patterns reveal how mosquitoes find hosts to transmit deadly diseases 2Glucosamine-like supplement suppresses multiple sclerosis attacks 2
(Date:12/24/2014)... NEW YORK , Dec. 24, 2014 /PRNewswire/ ... company advancing patient care in critical areas, announced the ... of common stock, and warrants to purchase up to ... offering price of $4.00 per share and $.01 per ... of $5.00, are exercisable immediately, and expire 5 years ...
(Date:12/24/2014)... Earlier this year in a June 24 ... the Adult Stem Cell Technology Center, LLC ( ASCTC ... appreciated unique property of adult tissue stem cells. ... in the Past, Important for the Future,” embodied the ... gave the address at the 4th World Congress on ...
(Date:12/24/2014)... Nashville Fertility Center announced that Dr. ... American Society for Reproductive Medicine (ASRM), a leading professional ... medicine. In his new role as treasurer, Dr. ... and will have a voice in furthering the mission ... ASRM since 1984 when he joined while conducting fellowship ...
(Date:12/24/2014)... December 23, 2014 PharmaBoardroom,s ... out today and available for free download , digs ... change and growth in the sector today. One ... successes has been in developing a homegrown pharmaceutical manufacturing base, ... production still remains some way off. A cursory comparison with ...
Breaking Biology Technology:PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3
... MADISON Wisconsins law enforcement agencies are slated to begin ... identify criminals. The training, sponsored by the Oshkosh Police Department, ... system allows photo-like images of suspects to be created quickly ... facial features, hairstyles, hats, scars and tattoos. , ,FACES, which ...
... is available for technology companies as part of a ... Technologys Advanced Technology Program . All U.S.-owned, for-profit ... all technology areas may be submitted. , ,The awards ... capital for visionary, high-technology businesses that will have an ...
... Friday designed to promote capital investment and technological entrepreneurship ... legislation, SB 261 , was only one of ... R-Brookfield, to hit the Assembly floor this session. Its ... Capital Companies Program, (WISCAP) is a revised version of ...
Cached Biology Technology:Wisconsin Assembly passes capital investment bill, revised CAPCO program not presented 2Wisconsin Assembly passes capital investment bill, revised CAPCO program not presented 3
Eliminate electrical interference from any analog signal, without filtering. Ideal for electrophysiology applications like EKG, EMG, and EEGs. Removes 50/60hz noise and harmonics caused by grounding ...
Request Info...
... Light Diagnostics Universal Amplicon Detection ... use in the qualitative detection ... by in vitro nucleic ... only; not to be used ...
{3,8-diamino-5-[3-(diethylmethylammonio)propyl]-6-phenylphenanthridinium diiodide}. ,250 ug/ml Propidium Iodide (PI) in PBS....
Biology Products: