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When temperatures get cold, newly-discovered process helps fruit flies cope
Date:7/21/2014

Cold-blooded animals cannot regulate their body temperature, so their cells are stressed when facing temperature extremes. Worse still, even at slightly colder temperatures, some biological processes in the cell are slowed down more than others, which should throw the cells' delicate chemical balance out of whack. Yet, those cells manage to keep their biological processes coordinated. Now researchers from the University of Rochester and the European Molecular Biology Laboratory have found out how they do that.

"The production of proteins is a key process in all cells, and it is important to make the right amounts of each protein at just the right time," said Michael Welte, an associate professor of biology at the University of Rochester. "What we have discovered are factors responsible for keeping that process perfectly coordinated in at least one type of cold-blooded animal."

Welte and his team made their discovery while studying the internal mechanisms of the egg cell of the fruit fly, known as Drosophila.

Welte explains that the production of certain proteins takes place along a type of assembly line that carries raw materials from the nucleus to the posterior end of the egg cell, where these proteins are then manufactured. When temperatures drop, the rate at which the proteins are built slows down significantly more than the rate at which the raw materials are deliveredsomething that has the potential of throwing off the entire operation. What keeps the assembly line functioningbased on the new researchis a protein called Klar. It does that by slowing down the rate at which the raw materials are delivered, to match the rate of protein building.

The research findings were published today in The Journal of Cell Biology.

The protein assembly line consists of microtubules that serve as train tracks on which the raw materialsincluding messenger RNA (mRNA)are carried to the protein-making
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Contact: Peter Iglinski/LeonorSierra
peter.iglinski@rochester.edu
585-275-4118
University of Rochester
Source:Eurekalert

Page: 1 2

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