Navigation Links
When temperatures get cold, newly-discovered process helps fruit flies cope
Date:7/21/2014

Cold-blooded animals cannot regulate their body temperature, so their cells are stressed when facing temperature extremes. Worse still, even at slightly colder temperatures, some biological processes in the cell are slowed down more than others, which should throw the cells' delicate chemical balance out of whack. Yet, those cells manage to keep their biological processes coordinated. Now researchers from the University of Rochester and the European Molecular Biology Laboratory have found out how they do that.

"The production of proteins is a key process in all cells, and it is important to make the right amounts of each protein at just the right time," said Michael Welte, an associate professor of biology at the University of Rochester. "What we have discovered are factors responsible for keeping that process perfectly coordinated in at least one type of cold-blooded animal."

Welte and his team made their discovery while studying the internal mechanisms of the egg cell of the fruit fly, known as Drosophila.

Welte explains that the production of certain proteins takes place along a type of assembly line that carries raw materials from the nucleus to the posterior end of the egg cell, where these proteins are then manufactured. When temperatures drop, the rate at which the proteins are built slows down significantly more than the rate at which the raw materials are deliveredsomething that has the potential of throwing off the entire operation. What keeps the assembly line functioningbased on the new researchis a protein called Klar. It does that by slowing down the rate at which the raw materials are delivered, to match the rate of protein building.

The research findings were published today in The Journal of Cell Biology.

The protein assembly line consists of microtubules that serve as train tracks on which the raw materialsincluding messenger RNA (mRNA)are carried to the protein-making machinery, called ribosomes. It's there that a protein called "Oskar" is produced. The role of Oskar is to mark the posterior end of the cell so that the future embryo forms its tail in the right place.

As temperatures decreased, Welte found that the protein-building process failed when Klar was removed from the egg cell. Only when Klar was present did the fruit fly develop properly.

Unlike fruit flies, humans and other warm-blooded animals do have a mechanism for adjusting internal temperatures. But Welte speculates that when internal temperatures do fluctuate in humans, as in the case of fevers, our cells may also need a way to coordinate the protein-building process. "While we don't have the Klar protein in our cells, the mechanism for producing proteins is very similar."


'/>"/>
Contact: Peter Iglinski/LeonorSierra
peter.iglinski@rochester.edu
585-275-4118
University of Rochester
Source:Eurekalert

Related biology news :

1. Rising ocean temperatures harm protected coral reefs
2. Rise in temperatures and CO2 follow each other closely in climate change
3. Increase in metal concentrations in Rocky Mountain watershed tied to warming temperatures
4. Warmer temperatures make new USDA plant zone map obsolete
5. Sea surface temperatures reach record highs on Northeast continental shelf
6. Warming temperatures cause aquatic animals to shrink the most
7. Himalayan glaciers will shrink even if temperatures hold steady
8. Low rainfall and extreme temperatures double risk of baby elephant deaths
9. Tree die-off triggered by hotter temperatures
10. New research helps place modern temperatures into a more complete statistical framework
11. Sea surface temperatures reach highest level in 150 years
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/27/2016)... , Jan. 27, 2016  Rite Track, Inc. ... in West Chester, Ohio announced ... winning service staff, based in Austin, Texas ... and ability to provide modifications, installations and technical support ... , CEO of PLUS, commented, "PLUS has provided world ...
(Date:1/22/2016)... , January 22, 2016 ... the addition of the  "Global Behavioral ... offering. --> http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) ... "Global Behavioral Biometric Market 2016-2020"  report ... Research and Markets ( http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has ...
(Date:1/20/2016)... 20, 2016 A market that just keeps ... from the explosion in genomics knowledge. Learn all about ... A range of dynamic trends are pushing market growth ... medicine - pharmacogenomics - pathogen evolution - next generation ... - greater understanding of the role of genetic material ...
Breaking Biology News(10 mins):
(Date:2/9/2016)... ... February 09, 2016 , ... PharmApprove announced ... the National Organization for Rare Disorders (NORD). Dorman will lead PharmApprove efforts to ... heard throughout the drug regulatory review process. , “Adding Diane Dorman is just ...
(Date:2/9/2016)... YORK , Feb. 9, 2016 This ... analyzes the current and future prospects of the market ... this report include companies engaged in the manufacture of ... an executive summary with a market snapshot providing the ... scope of this report. This section also provides the ...
(Date:2/9/2016)... Three-Year Initiative Supports Next Generation of Medical Geneticists and  ... Experiences SHPG ) ... of children born with rare diseases, as well as the future ... a new initiative designed to positively affect the lives of children ... disease care. --> To mark the company,s founding 30 ...
(Date:2/9/2016)... , Feb. 9, 2016 ... Inhibitors-Pipeline Insights, 2016", report provides in depth ... development activities around the Protein-Tyrosine Phosphatase 1B ... product profiles in various stages of development ... II, Phase III and Preregistration. Report covers ...
Breaking Biology Technology: