Navigation Links
When it comes to sleep research, fruit flies and people make unlikely bedfellows
Date:1/13/2009

You may never hear fruit flies snore, but rest assured that when you're asleep they are too. According to research published in the January 2009 issue of the journal GENETICS (http://www.genetics.org), scientists from the University of Missouri-Kansas City have shown that the circadian rhythms (sleep/wake cycles) of fruit flies and vertebrates are regulated by some of the same "cellular machinery" as that of humans. This study is significant because the sleep-regulating enzyme analyzed in this research is one of only a few possible drug targets for circadian problems that can lead to seasonal affective disorder (SAD), insomnia, and possibly some cancers.

"Modern society functions 24 hours a day and has produced more circadian problems than our ancestors ever faced," said Jeffrey Price, Ph.D., the senior scientist involved in the research. "I hope our work will allow us to better understand and alleviate these problems."

In addition to showing that this drug target has similar circadian functions in flies and humans, the study confirms that fruit flies are attractive and viable animal models for circadian research because their circadian "machinery" is remarkably similar to that in humans and they can be bred easily and rapidly. Moreover, this study provides compelling evidence that from an evolutionary point of view, circadian rhythms have been virtually unchanged since the days when humans and fruit flies shared a common ancestor.

Price and his colleagues made this discovery using a combination of biochemical and genetic approaches. For the biochemical approaches, normal and mutated versions of the fruit fly's sleep-regulating enzyme (DBT protein kinase) were expressed in insect cells and purified to determine how well each would work. The genetic approaches involved altering fruit flies to have the same sleep-altering gene mutations as vertebrates. The mutant proteins (either the fruit fly or vertebrate protein) were expressed in the fruit fly's circadian neurons and produced very similar effects on the fruit fly's circadian period.

"Every month our journal features articles that illustrate why creatures like fruit flies provide good models for studying human disease, and this article is an especially good example of that," said Mark Johnston, Ph.D., Editor-in-Chief of GENETICS. "These findings will help guide development of drugs that safely alter the sleep/wake cycle."

According to the Centers for Disease Control and Prevention, more than 25 percent of the U.S. population report not getting enough sleep on occasion, while almost 10 percent experience chronic insomnia. Insufficient sleep is associated with several diseases and conditions, such as diabetes, cardiovascular disease, obesity, and depression. It also is responsible for accidents that cause substantial injury and disability each year.


'/>"/>

Contact: Tracey DePellegrin Connelly
td2p@andrew.cmu.edu
412-268-1812
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Drug could improve pregnancy outcomes in wider range of women with insulin resistance
2. UNH becomes first university in nation to use landfill gas as primary energy source
3. When it comes fighting to C. difficile, the Palme dOr goes to soap and warm water
4. Scientists find how amber becomes death trap for watery creatures
5. Forests could benefit when fall color comes late
6. DFG welcomes decision on stem cell research by German parliament
7. Meteorology student SOARS toward excellence, overcomes obstacles
8. National Inventors Hall of Fame welcomes 2008 inductees
9. Mouse study: When it comes to living longer, its better to go hungry than go running
10. When it comes to female red squirrels, it seems any male will do
11. Treatment delays result in poor outcomes for men with breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2016)... April 15, 2016 Research ... Gait Biometrics Market 2016-2020,"  report to their offering.  ... ) , ,The global gait biometrics market is ... during the period 2016-2020. Gait analysis ... can be used to compute factors that are ...
(Date:3/31/2016)... 31, 2016   ... the "Company") LegacyXChange is excited to release ... soon to be launched online site for trading 100% ... ) will also provide potential shareholders a sense of ... to an industry that is notorious for fraud. The ...
(Date:3/23/2016)... Massachusetts , March 23, 2016 /PRNewswire/ ... im Interesse erhöhter Sicherheit Gesichts- und Stimmerkennung ... Xura, Inc. (NASDAQ: MESG ), ... bekannt, dass das Unternehmen mit SpeechPro zusammenarbeitet, ... aus der Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 27, 2016   Ginkgo Bioworks , a leading ... was today awarded as one of the World ... world,s most innovative companies. Ginkgo Bioworks is engineering ... real world in the nutrition, health and consumer ... with customers including Fortune 500 companies to design ...
(Date:6/24/2016)... ... ... While the majority of commercial spectrophotometers and fluorometers use the z-dimension of ... higher end machines that use the more unconventional z-dimension of 20mm. Z-dimension ... of the cuvette holder. , FireflySci has developed several Agilent flow cell product ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... is pleased to announce the launch of their brand, UP4™ Probiotics, into Target ... over 35 years, is proud to add Target to its list of well-respected ...
(Date:6/23/2016)... , June 23, 2016 A person commits ... the crime scene to track the criminal down. ... U.S. Food and Drug Administration (FDA) uses DNA evidence to ... Sound far-fetched? It,s not. The FDA has ... to support investigations of foodborne illnesses. Put as simply as ...
Breaking Biology Technology: